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Pfizer submits Covid vaccine to FDA for approval, to distribute in December

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Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#52
post #37

This will save lives. However I imagine most people will end up getting the Oxford vaccine, that doesn't have the storage requirements or need a second dose and is a fraction of the cost.

Well, I wouldn't be so happy.

Think about it. Out of million people only small percentage would become infected with covid and of that, only small percentage would die.

On the other hand, vaccine must be distributed to everybody. Alternatively to people who, by occupation, have to contact many other people, daily.

We don't know yet if there are complications from the vaccine. It is not possible to judge long term effects of anything based on very short exposure.

The value of vaccine is in preventing future infections, but for a given person now it is not yet know if the vaccine is actually a good deal or not. Only time will tell.

Looking at this selfishly and from PoV of game theory, the best decision is to let vaccinate everybody else but don't take vaccine yourself. Obviously, not everybody can make same decision.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#55

Does this feel rushed to anyone? Why don’t they stagger the release? Why jump from initial trials involving thousands to widespread distribution involving millions?

Basically because the mechanisms this generation of vaccine consist of are much less complex than any before.

Historically, vaccines were huge biological black boxes with all kinds of biomachinery inside that weren't understood at all, that weren't even known. Vaccines were routinely developed, purely by clever trial and error search strategies long before any of their actual mechanisms were understood. In particular this meant that most of the molecular machinery included weren't even needed for the effect. You want a lipstick so you steal cars until you find one that contains a lipstick. Who knows what else you acquired.

This generation of vaccines is the opposite, they know exactly what molecules they want, where, for what reason. And it's basically one molecule. One molecule you'd be exposed to, in much larger dosage, anyways one day if the vaccines are unsuccessful (the virus is well past flash-in-the-pan now, it will become endemic unless perhaps vaccination also prevents spread and not only illness, which isn't clear at all). The only uncertainty was the question of whether the immune system will react to the sound protein if it comes without a virus attached and wether an immune system that was already acquainted with that molecule will actually work better against the actual virus, not worse (some viruses are even worse if the immune system thinks it already has a defense and focuses on that but the defense is only partial). Both are easily checked in trials if you don't skip them (we didn't). The black box full of surprises of historic vaccines, the trunk of the car that you stole to find lipstick, it's just not there.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#57
post #52
post #37

This will save lives. However I imagine most people will end up getting the Oxford vaccine, that doesn't have the storage requirements or need a second dose and is a fraction of the cost.

Well, I wouldn't be so happy. Think about it. Out of million people only small percentage would become infected with covid and of that, only small percentage would die. On the other hand, vaccine must be distributed to everybody. Alternatively to people who, by occupation, have to contact many other people, daily. We don't know yet if there are complications from the vaccine. It is not possible to judge long term eff…

Is there an example of a vaccine in history that produced no initial side effects but only very long term side effects (ie. several years later)?

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#59
post #27
post #21

Anyone know why China is not on the list of countries in which Pfizer is seeking regulatory approval?

Because China already has a "national" vaccine, and they see no chance getting through Chinese bureaucracy for such a politicised deal?

"yes you can sell here, we only need to know the ingredients and know-how of this vaccine to approve its safety"

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#60

-Great great news. Can't wait to get the needle in the arm ASAP. -Seems extremely effective at limiting covid disease. -Very curious as to how long will the vaccine immunity will last? -Seems with the second dose for 18-55 year olds, perhaps 75% will feel fatigue, 50% have chills and 20% will have a fever.[1] This hasn't been widely shared yet and I'm a bit concerned how the public will react. -Safety: Given the huge…

Not sure why you are being downvoted. Those are legitimate concerns. This vaccine has only been tested for a small number of months. We simply don't know whether it is safe long-term and what exact statistical level of safety it has. This is not some quasi-scientific bullshit about energies, these are simple medical facts. We have not been testing them. Testing is the only scientific method that matters. I don't thin…

My theory is that anti vaxxers have poisoned the public conversation (if you say anything questioning a vaccine you shall be shunned). I plan to get this vaccine and generally trust our scientific institutions.

But of course there are legitimate safety concerns with injecting stuff into people - which is why they ran a huge study to show that there are no short term safety concerns.

I'm just asking (not implying anything) a real medical question I don't know the answer to - how do we know this vaccine doesn't increase the chances of some condition 20 years later when the median time people have been vaccinated is two months? And with a brand new vaccine platform that has never been used before...

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