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Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

ncbi.nlm.nih.gov

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Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#51
post #29

Earlier quoted context omitted.

Took adderal for year. Completely life changing. My focus and energy level were on par with a normal persons. Unfortunately it was far too hard on the body. Started stroking out on it. Plus it interacted with almost every Medicane I’ve been prescribed. Tried vyvanse. Only one side effect. The deepest most profound sadness imaginable. Would sit for hours just “sad”. Nothing was bothering me. Worked fine aside from tha…

> Started stroking out on it I've never heard this particular phrase before and I can only guess it's meaning vaguely from the context. What does it mean?

Elevated BP & hypertension causing Serious Negative cardiovascular issues to the point of immobilization and even arrhythmia.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#52
post #7

This was an interesting read but, as an adult with ADHD, all I get out of this is that medication is even more of a benefit to those with real difficulties coping with their ADHD. I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. Now I take med…

I've been on Adderall for 5 years ... I'm 43 right now.

It really HAS changed my life. What I've found is that over the long term you're able to perform much much better.

By the time I was in my 30s I had developed coping skills which worked for the most part but I would find myself getting demotivated and defocused sometimes on long term priorities and sometimes unable to recommit to them.

Adderall totally changed that. I'm able to focus on tasks long term AND even if something bad happens in my life I'm able to keep right on track.

It's also helped me stay more positive knowing that projects get completed and there's nothing preventing me from accomplishing what I want to accomplish.

There are some downsides though:

- Adderall is illegal in most countries so you're not even allowed to travel with it in some places. I didn't really know this at first and I wish they would tell you. Most countries will overlook it but if you're China they could totally use it as an excuse to harass you if they wanted.

- It's very addictive. If I forget my meds it's basically impossible to function.

- It's VERY hard to get since it's a controlled substance. I'm only able to get it 72 hours ahead of time and if they're out of stock sometimes I have to wait. DO NOT wait until the last minute. Get it as early as possible.

- Some people have problems with off brands of XR (extended release) that has a different formulation. There's no standardization on the XR process and I think it's vendor specific.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#53
Does anyone else think the NIH online reader is a disastrous UI for mobile? I mean yes there is a PDF link at the top, please don't point out the obvious. I just mean who the heck checked the box to accept this work, or worse yet demanded this horrible pagination interface? I'm sure that they've been promoted to the highest levels in this fail-up world...

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#54
post #7

This was an interesting read but, as an adult with ADHD, all I get out of this is that medication is even more of a benefit to those with real difficulties coping with their ADHD. I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. Now I take med…

Took adderal for year. Completely life changing. My focus and energy level were on par with a normal persons. Unfortunately it was far too hard on the body. Started stroking out on it. Plus it interacted with almost every Medicane I’ve been prescribed. Tried vyvanse. Only one side effect. The deepest most profound sadness imaginable. Would sit for hours just “sad”. Nothing was bothering me. Worked fine aside from tha…

They're your kids so it's your decision but might I suggest trying a low dose of Adderall or other medication and ramp up over time?

ADD was REALLY hard on me when I was a kid. I had a difficulty making friends. I got really bad grades in school. Got in fights. Made me depressed and I thought something was broken with me.

You can start with 5mg and then ramp up from there. I'm on 15mg. I can't really feel 5m and 20mg is far too much.

At lower doses they won't really have any side effects and then you can keep them on for 90-120 days to see how they tolerate it.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#55
post #7

This was an interesting read but, as an adult with ADHD, all I get out of this is that medication is even more of a benefit to those with real difficulties coping with their ADHD. I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. Now I take med…

Which "more modern" medication are you on, out of curiosity?

Ritalin causes side effects for me as soon as I start to hit the therapeutic dose when titrating.

Adderall is terrible for me.

My youngest daughter is undoubtedly ADHD, and the insurance company requires you to try the first two before they will approve a third...

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#56
> children with ADHD require stronger incentives to modify their behavior than those without ADHD5; they also show a failure to delay gratification, have impaired responses to partial schedules of reinforcement, and preference for small immediate rewards over larger delayed rewards6,7.

I'm an adult with ADHD and that paragraph describes me to a T, though it definitely was worse as a child

I got my first D grade in a subject in fifth grade, and the next seven years were basically my parents trying every tool at their disposal to motivate me to get better grades.

I was on academic probation four more terms than I wasn't in college, and graduated with a low C average after 5.5 years, plus two summer terms.

I got hired at the only company that forgot to ask for my GPA.

I think if I were just sightly less intelligent, I would have been in a world of hurt and possibly dead by now.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#58
post #7

This was an interesting read but, as an adult with ADHD, all I get out of this is that medication is even more of a benefit to those with real difficulties coping with their ADHD. I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. Now I take med…

We are trying out various ADHD meds for my son and every one is like a deal with the devil - it helps with some things, but leaves him twice as wired when it wears off, or makes him sleepy or keeps him awake at night. I hope in the future we can get more targetted treatments without so many side effects.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#59

Earlier quoted context omitted.

Took adderal for year. Completely life changing. My focus and energy level were on par with a normal persons. Unfortunately it was far too hard on the body. Started stroking out on it. Plus it interacted with almost every Medicane I’ve been prescribed. Tried vyvanse. Only one side effect. The deepest most profound sadness imaginable. Would sit for hours just “sad”. Nothing was bothering me. Worked fine aside from tha…

Having gone through this with my fam, given that you seem to have reactions to every med, have you considered it may be autism or aspurgers? ADHD and autism are often seen together, and reactions to other meds also seems to be fairly common. I just wanted to throw that out there because this realization that it's not just ADHD, not just anxiety, etc has changed our life dramatically... and there are meds that can hel…

This is possible. When I was diagnosed, it was autism masking ADHD (apparently the other way around is more common though) because I have all the ADHD issues with everything except my special interest. I was told that ADHD more commonly masks autism though, so it's certainly worth exploring the possibility.

Re: Adults with ADHD show decreased function in brain dopamine reward pathway (2010)

#60
post #7

This was an interesting read but, as an adult with ADHD, all I get out of this is that medication is even more of a benefit to those with real difficulties coping with their ADHD. I've always been one to 'just deal with it' but after a few years of working through school and seeing my younger brothers go through the same thing with medication, I realized that I was essentially just handicapping myself. Now I take med…

Took adderal for year. Completely life changing. My focus and energy level were on par with a normal persons. Unfortunately it was far too hard on the body. Started stroking out on it. Plus it interacted with almost every Medicane I’ve been prescribed. Tried vyvanse. Only one side effect. The deepest most profound sadness imaginable. Would sit for hours just “sad”. Nothing was bothering me. Worked fine aside from tha…

So, heres a lifer's perspective, if it helps.

If they aspire to aviator,stay away. If you really, really worry about locking them into somewhere with access to a Schedule II, then consider not doing it, but I can't overstate how effective and life changing the right treatment regimen is. For me it was like life going from black and white to full color. It can be a bit depressing 20-39 years down the line, and I'm considering getting something started with a Congress person to dial back some of the draconian controls if at all possible, because, not going to lie, it is disruptive as all hell to the lengths things have been allowed to achieve

I've seen other parents with kids who clearly have it do nothing, and the Kids are the ones who really suffer because they don't have a clue what is "wrong".

I kick the wall I'm physiologically disincluded from aviating, but I wouldn't trade all the life experiences I've been able to navigate because of the medication for that, and there's nothing that says the world has to remain so unfriendly to Adderall/ADHD med takers as well.

The Hypertension can be a problem, but a small maintenance dose of a blood pressure meds (or Hawthorne!) Tends to do the trick for me, but work with your doctor.

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