Earlier quoted context omitted.
Why would anyone choose to live in Manhattan when their job is entirely remote?
I’m not sure what you mean. New York City is famously regarded as a great city for music, art, museums, theatre, cinema, comedy, architecture, food, nightlife, cultural diversity, and more. I have never heard the sentiment “my NYC job is so great, I just wish it were in another town.”
High rent like pizza said as well as crowdedness, having to choose between transit and driving in really bad traffic, general city complaints. I've used the subways in NYC a few times and I really wouldn't like having to do that all the time. There is some great stuff there like the Museum of Natural History but I think I'd rather live in a surrounding suburb or something, or Hawaii like the other commenter suggested.
On the transit subject, the lack of car reliance is nice in theory, but I honestly found my short experience of taking MTA subways around less enjoyable than driving. Very crowded, jerked so hard when it started moving that I almost fell over, and the walks between connections can be tiring if there's a rush to get there on time or it's a long distance (or both - running from one side of the PABT to the other isn't fun when you're not in great shape)