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Earlier quoted context omitted.
I was talking about type 2 diabetes, not type 1. You're of course correct regarding type 1.
Speaking as a T1D, please always specify. It's a shame these two totally unrelated diseases have the same name.
> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…
Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. With the right compound in the needle, thst sounds like an incredible way to a…
Earlier quoted context omitted.
What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…
> I don't know a single diabetic who cares about injections and blood sugar tests. I'm diabetic and the sole reason I don't check my blood sugar (unless I think something is drastically out of whack) is that it takes me upwards of 30 minutes to do a finger prick for testing. My anxiety skyrockets and nothing I do can tell me that it's not going to be excruciating. Most of the time I end up having my wife do it, which…
> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…
What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…
Earlier quoted context omitted.
I'm saying Novo Nordisk produces insulin, and in doing so causes downward pressure on insulin prices thanks to basic economics. (When the supply of a good increases at the same level of demand, price falls.) This is true for both type 1 and type 2 diabetics. In Novo's case, they have two kinds of long-acting insulin analogue taken 1-2 times per day for both T1 and T2; they have to my knowledge the only ultra-long-act…
Insulin prices have inflated by about 500% over the past two decades in the United States. Novo Nordisk's profits have seen a similar rise. Now, im no economitician, but I'd wager a vial of Fiasp® that there's more than just supply and demand going on here.
> Novo Nordisk also published data for two of their insulin products, NovoLog and NovoLog FlexPen. Since the early 2000s, the CAGRs for the list prices for NovoLog and NovoLog FlexPen (Fig. 7) have been in the range of 9.8–9.9% (22). This translated into large total increases in the list prices: 353% (2001–2016) for a NovoLog vial and 270% (2003–2016) for a FlexPen. In contrast, net prices received by the manufacturer increased at a more modest rate (3–36%) with CAGRs of 0.2–2.1%. Novo Nordisk, Eli Lilly, and Sanofi have reported that rebates have grown rapidly in recent years, representing more than 40% of U.S. gross sales in some cases
[0] - http://care.diabetesjournals.org/content/diacare/41/6/1299.f...
Earlier quoted context omitted.
Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. With the right compound in the needle, thst sounds like an incredible way to a…
Sorry, I don't think so. Getting someone to swallow a pill sounds strictly harder then getting them to swallow a liquid.
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Read up on the matter. The culprits are pharmacy benefits managers who push producers to increase list prices while demanding obscene rebates that are never passed on to the consumers. Most producers don’t disclaim the rebates, but Lars Fruegaard (Novos CEO) is on record saying that it increased from 64% to 67% last year. So pharmacy benefits managers are pushing up the list price but less and less is getting through…
>Read up on the matter. Slightly off-topic, but could you talk about what pharmacy benefits managers are supposed to do and actually do, for insulin especially, and their effect on the market? I Googled this term but can't make of sense of your comment based on what I've read. (The definitions of pharmacy benefits managers that I found have nothing to do with what you wrote.)
[0] https://en.wikipedia.org/wiki/Pharmacy_benefit_management#Co...
Depending on what I eat, I need different ammounts of insulin, and adjust the dose acordingly using my insulin pen and needle. How does one adjust the dose in a pill? Do I take more or fewer pills? They mention the insulin is "freeze dried". What does this mean in practice? Do I need to carry around a climate controlled box with my insulin in?
"Freeze drying is a water removal process typically used to preserve perishable materials, to extend shelf life or make the material more convenient for transport. Freeze drying works by freezing the material, then reducing the pressure and adding heat to allow the frozen water in the material to sublimate."
You freeze it or shock freeze it and then "distill" the water of in vacuum. The ice goes into the vapor phase, skipping the liquid phase. This process is called sublimation and part of each first year high school chemistry curriculum.
The substance, insulin or other peptides, will be stable after this at room temperature for some time.
I’m hoping Apple will pull out a miracle and able to measure blood sugar with the Apple Watch. With that data, people can make apps to do really cool things to help that person out.