Manufacturing jobs are booming in the US. The very people that you're implying are hopeless, that specific demographic, have access to blue collar jobs in a way they haven't in nearly a generation. The US hasn't seen this kind of sustained manufacturing job growth since the mid 1990s.
The US has drug problems, and has for 50 years, that other first or second tier nations in worse structural condition never picked up. This goes all the way back to peak US economics of the 1960s and early 1970s, when the US had a standard of living that it has taken the best European nations 50 years to catch up to. The opioid crisis is the latest extension of the US being a drug abusing nation, which it has been for a very long time, even at the peak of US economic success when it had 1/2 of all global manufacturing. It has had multiple heroin waves, multiple cocaine craze waves, multiple pill abusing waves.
The people of Spain didn't overdose at 2x or 4x the rate of the US despite having a drastically worse economic situation. Their economic desperation is still far beyond that of the US.
The standard response to that is: yeah, but the US doesn't have a welfare state. Yes it does, it has a massive welfare state, and its welfare spending as a percentage of GDP is higher than Canada or Australia.
The opioid problem has particularly hit poorer Americans. Why aren't Bulgarians or Moldovans overdosing at far higher numbers? They're radically poorer. Part of this equation is access: Americans have massive, low cost, easy access to all the drugs. People in the US have an almost unique position in the world in regards to having enough money, easy access and combining it with the way drugs get pushed to Americans.
Some of this is in fact unique to the US and doesn't require there be a particular high level of stress.
Every economic metric indicates Americans are doing better today than they were seven years ago, and yet the opioid crisis isn't receding and it's far worse than it was seven years ago.
Japan has lost a minimum of 1/3 of its standard of living in 15-20 years. They're not overdosing on opioids like people in the US are. They've suffered far worse than people in the US have.
Every culture behaves differently under stress, there's no question about that. There's also zero evidence that the on-going opioid crisis is a result of active high level desperation. That's where it started; those are not the same things.
Do people in Sweden and Belgium commit suicide at higher rates than people in the US, because their standard of living is collapsing? Belgium's suicide rate is nearly 100% higher today than the US rate was in the year 2000. Does wealthy Europe have among the highest rates of suicide on earth because it's so terrible there and they're under incredible economic stress? Or is it more likely these cultural issue are in fact complex rather than simple.