Earlier quoted context omitted.
Whether or not NASA (and by extension Boeing) can afford to lose a mission isn't dependent on how much it costs but on public relations and legislation. Money has diminishing returns when it comes to mission success rates. A common ballpark example I've heard from JPL PMs: you can spend $500 million on one launch with a 95% chance of putting one satellite in orbit - or - you could spend $250 million per launch on two…
When a mission is $250m, I wonder how much additional a second identical copy would cost. For example, if $200m of that is R&D, it would only cost $300m for two missions.
If you budget for two 80% launches, however, $150-200 million gets you two satellites, you spend $125-200 million on launches (you cant wait until your first failure to put money down for the second launch so it's at least a 1.25x multiplier), and $25-100 million on extra staffing costs (you can't risk losing your top PIs/scientists between the first and second launch so you have to pay them the entire time).
Ideally, both options would be evaluated independent of popular sentiment. For manned exploration or cutting edge missions like the Mars rovers, we should strive for that 95% single mission success rate. Otherwise we should err towards getting more science done faster and cheaper.