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Nicotinamide riboside effects on aging similar to caloric restriction

colorado.edu

51–60 of 86 posts

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#51
post #20

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

Thorne has a fairly cheap one but I’m not sure how much more effective any of those are than high dose B3.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#53
post #32
post #10

Earlier quoted context omitted.

Thanks! we now have the right vowel above.

As long as you're adjusting the title, I'll point out that the study does not actually demonstrate that the effects on aging are similar. Just that taking the pill creates a metabolite that might possibly have an effect on aging.

Happy to change it again, but that's harder than vowel swapping. Anyone care to suggest a more accurate title?

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#54
post #35
post #20

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/

I have read pieces on NR that claim NR is better at "activating" sirtuin production compared with niacin. Is this a load of baloney? Or is NR really different in its effect?

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#55

Is this the same product that Elysium Health sells? Also, the company ChromaDex seems to have an exclusive right to sell the compound. Anyone think there's an upside to the stock?

Yes, it is: https://www.elysiumhealth.com/supplement-facts

Highly doubt there's an exclusive right to sell a compound like this. I know there are multiple suppliers so doesn't seem to be any patents involved.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#56

I think calorie restriction is a more interesting idea, because it forces you to think about eating high-nutrient foods. The first things I did were to eliminate sugars and other processed ingredients, including all flours. Continuing to eat junk and assuming that pills and supplements will compensate for that is probably not a good idea.

Compliance for CR is near impossible though. I'm a believer in it but am still 10 pounds overweight. It won't work for everyone, obviously (because so many of us are overweight).

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#57
post #44

Earlier quoted context omitted.

I don't think the average person has access to a Mass Spec or Liquid Chromatography equipment.

https://www.scienceexchange.com $100-150 to run a sample through LC-MS via any one of dozens of small laboratory groups. Most are willing to explain things to a newcomer who is working his or her way through learning the ropes.

As a former chemist, I'd want to run a few more tests than just LC-MS. Like heavy metal levels and residual solvent levels.

Plenty of impurities don't show up in LC-MS.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#58

I think calorie restriction is a more interesting idea, because it forces you to think about eating high-nutrient foods. The first things I did were to eliminate sugars and other processed ingredients, including all flours. Continuing to eat junk and assuming that pills and supplements will compensate for that is probably not a good idea.

Compliance for CR is near impossible though. I'm a believer in it but am still 10 pounds overweight. It won't work for everyone, obviously (because so many of us are overweight).

It's not impossible. Look at the CR experiments like CALERIE. Dropout is something like 10-20%, similar to intermittent fasting or other kinds of diets.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#59
post #35
post #20

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/

I've been taking Niagen for a couple of months, and I can say that for me it feels much better than niacin or niacinamide. I don't know why (perhaps I have some niacin metabolism problem, or the niacin interferes with some other impaired process such as the methylation cycle).

Also there seems to be some synergy between Niagen and resveratrol and pterostilbene that I can clearly notice. Foods that work well with Niagen are raisin(-bread) and olive oil. Of course, ymmv.

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