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Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

nature.com

51–60 of 80 posts

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#51

Isn't regular Ketamine use especially bad for the bladder? I recall reading multiple anecdotes from the Erowid ketamine vaults where people lost their bladders due to recreational Ketamine use.

It's not great for your bladder, but it takes a serious ketamine habit to get to that point - I've known people doing a couple of ounces a week or more for several years who were fine, but tolerance builds up enough over time that people can consume some huge amounts on a daily basis - and injecting it intramuscularly makes it even easier to do so.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#52
post #37

Earlier quoted context omitted.

It's a huge problem for recreational use. Some individuals have trouble with it even with prescription ketamine, but it's not nearly as common. Last time I asked him, my doctor hasn't had any patients who were forced to discontinue treatment because of it. n=1, but I've been receiving ketamine therapy for about 6 years and have not developed ketamine cystitis.

Are recreational doses significantly higher than prescription doses? Why the difference?

The research for depression used much lower doses of ketamine than recreational use. One UK clinic was using about 80 mg as a max dose. https://www.oxfordhealth.nhs.uk/news/first-uk-study-of-ketam...

A large recreational dose may be 250 mg.

This is partly because the recreational dose is looking for different effects, so they use more. And because people build up a tolerance.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#53

I have been looking into Ketamine as there is a clinic which administers Ketamine therapy in my area. The disappointing thing is that it looks like the effects are short lived, and one may need "booster" treatments every 4 weeks, at $400 a shot, for years and possibly forever. I hope with this understanding, we come up with something more permanent.

It's not that expensive on darknet markets.

I don't think DNM's are the place to direct people experiencing severe depression. It's not only K they might find there. This directive is also potentially damaging to the above-ground progress advocates have been fighting so hard to achieve. I don't think I need to go into the safety issues around self-administration, either.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#54
post #50
post #27

Earlier quoted context omitted.

Ketamine is a generic drug and dirt cheap. I just checked and it's under $10 for a vial with enough to use in surgery, not even this setting. The $400 must be the clinic charge. I'm not sure what administration looks like, but a regular doctor's visit is $100-$150 and if the patient needs to stay for a longer period of time until it's safe to release them, $400 doesn't seem that far off of what you'd expect.

That's on the low end. I've looked into it and seen prices on the order of $1000-1500 per treatment. If you filter those out, many metro areas simply have no provider that charges what would seem to be a justifiable price. Abusive pricing is a big problem for this product it seems. Several advocacy sites that I saw that maintain provider lists make note of this.

Is it abusive pricing or are they covering for potential legal issues, etc? It would be great to hear from a clinician with first-hand experience.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#55

I have been looking into Ketamine as there is a clinic which administers Ketamine therapy in my area. The disappointing thing is that it looks like the effects are short lived, and one may need "booster" treatments every 4 weeks, at $400 a shot, for years and possibly forever. I hope with this understanding, we come up with something more permanent.

It's not that expensive on darknet markets.

Even assuming the product is safe, using darknet markets also has legal issues. (I don't agree that it should, but it does.) "Overpaying" $380 to be administered a known safe dose of ketamine in a place surrounded by medical professionals and know you're in the clear legally sure sounds like a fair deal to me when the alternative could end up involving an arrest record and possible prison time, even if everything involved with self-dosing goes just fine.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#56

Isn't regular Ketamine use especially bad for the bladder? I recall reading multiple anecdotes from the Erowid ketamine vaults where people lost their bladders due to recreational Ketamine use.

Those people were using 10-20x a typical recreational dose, daily.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#57

I have been looking into Ketamine as there is a clinic which administers Ketamine therapy in my area. The disappointing thing is that it looks like the effects are short lived, and one may need "booster" treatments every 4 weeks, at $400 a shot, for years and possibly forever. I hope with this understanding, we come up with something more permanent.

$400/month seems a very cheap price for getting your life back.

I agree that $10/session does sound better. That's what you pay (at most) for LSD, the traditional longer-term anti-depressive and anti-anxiety effect being there as well (3-6 months).

But: You have to buy a test kit (an additional $25/kit) and be extremely well informed about what do to and what not to do. And plan everything in detail and very carefully. Don't expect miracles if you're not serious about it.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#58
post #13

Isn't regular Ketamine use especially bad for the bladder? I recall reading multiple anecdotes from the Erowid ketamine vaults where people lost their bladders due to recreational Ketamine use.

yes https://www.ncbi.nlm.nih.gov/pubmed/27001627

Why is this being downvoted?

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#59

Earlier quoted context omitted.

If I was going to use ketamine, I'd prefer to get it from a reputable source.

Reputation is the key service of darknet markets. If you would prefer to pay $380 extra every four weeks, that's your call.

By reputable I mean manufactured in an approved facility to Health Canada standards (or equivalent). It seems unlikely that some dude on darknet would meet these standards. It's like saying that your local drug dealer has a good reputation because he hasn't killed too many people with fentanyl.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#60

Earlier quoted context omitted.

Reputation is the key service of darknet markets. If you would prefer to pay $380 extra every four weeks, that's your call.

By reputable I mean manufactured in an approved facility to Health Canada standards (or equivalent). It seems unlikely that some dude on darknet would meet these standards. It's like saying that your local drug dealer has a good reputation because he hasn't killed too many people with fentanyl.

Darknet stores are mostly distributors not manufacturers of pharmacological products. They are usually sourced from corrupt legitimate medical world supply chains. The economic reality is that there is almost no margin in wholesaling some of this stuff. Starting a yet another factory to make off-patent generic drugs would cost more than the probable medium term profits, especially given that you can more easily acquire from an existing producer. More recent / patented / specialized pharma products are probably harder to synthesize. Therefore, you can rest fairly assured a large-scale supplier with good reputation on the darknet markets is selling real stuff. This is true particularly in the case of generic drugs where, like ketamine, there is already zero patent global production.
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