51–60 of 67 posts
I read the paper, I saw the plots accompanying the paper, and I tried following the rabbit hole in search of some raw data that I can get my hands on, just to see if I can. Perhaps the data is the result of the experiments that have been paid for by a third party, fine, but please mention that! People might be willing to pay for it, for example, me! What's wrong with "Here's the raw data, here's how we measured it, H…
Earlier quoted context omitted.
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
And I believe the max dose is even higher - 3200mg per day (800mg 4 times per day).
Earlier quoted context omitted.
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
And I believe the max dose is even higher - 3200mg per day (800mg 4 times per day).
Earlier quoted context omitted.
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
I'm not saying it's an overdose (and their tests of renal and hepatic function corroborate that) But it's not a dose people will commonly take in their "day to day" activities and ideally not something that is done without medical supervision
A lot of people who exercise multiple times a week take "Vitamin I" every day. So do people who have frequent headaches, back or joint pain, etc. I probably came close to these levels during a bout of plantar fasciitis, though I've since switched to naproxen in such cases. It might not be common in your immediate circle, but in the broader world it's not rare enough to raise any eyebrows.
Earlier quoted context omitted.
This is exactly the motivation behind the Loom file format[0] being developed and used in the molecular neurobiology-group I work for[1]. It is an HDF5-based file format for 'omics data, to deal with the ever-growing size of the data sets. I specifically work on the Loom Viewer[1], a SPA that we're trying to design in such a way that it will be really easy and cheap for research groups to host and share these loom fi…
What's the difference between this and jupyter? besides the file format itself obviously
The viewer is a specialised application: it has a server and client. The server extracts (meta)data requested by the client from a loom file, and serves it as JSON. The client then uses this metadata to generate plots. The off-line viewer is actually just running that server locally and opening it on localhost:8003.
That makes it better for sharing raw data on-line: most of the time, people do not need the full dataset of 27k+ genes, they're only interested in a dozen or so. This makes it easy to access that.
Hosting your own viewer is quite simple:
# this also installs the loom CLI
pip install loom-viewer
# start the server
loom --dataset-path [DATASET_PATH] --server --port [PORT_NUMBER]
We don't use a database; instead the server looks for loom files in a dataset folder like this:
[DATASET_PATH]\[PROJECT_FOLDER]\[LOOM FILE]
This probably not web-scale or really safe or anything, but we're talking small labs sharing data with other labs - the risks are different. These viewers will be accessed by a few biologists. Using files in a folder structure keeps it simple enough to set up for the less tech-savvy.
In theory, a third work-flow is also possible: having Jupyter open in one tab and manipulating the loom file from there, and the viewer in another.
There are three blocking issues for that, however:
- the stale cache problem I mentioned in the other comment,
- single writer/multiple reader support,
- the server needs to be an isolated sub-process due to gevent monkeypatching messing with Jupyter
Main issue here is dev-team of one person so... this might take some time.
I read the paper, I saw the plots accompanying the paper, and I tried following the rabbit hole in search of some raw data that I can get my hands on, just to see if I can. Perhaps the data is the result of the experiments that have been paid for by a third party, fine, but please mention that! People might be willing to pay for it, for example, me! What's wrong with "Here's the raw data, here's how we measured it, H…
Blame the journal. Scientists are generally pretty busy. Writing a (life sciences) paper is an incredible amount of work usually done in a short period of time. Preparing raw data and explaining what everything means is quite involved. If they don't have to do something they won't. The journal should mandate data access, then it will get done. This is crucial for human experiments, if only because the authors can los…
I'm not sure who is responsible for making a better way. Probably no one. Change is often a matter of someone taking initiative and there are a few parties that could, if they consider it important.
IMO, the "replication crisis" should be having a more far-reaching effect on the institution of science. In some fields, the crisis means that the efforts of an entire generation were largely wasted. In those same fields, it is almost business as usual, with new unreplicable experiments being published. Knowledge was not actually being built. In some fields, the institutional scientific method (journals, peer review..) was not really practicing the scientific method, not practicing science.
I don't know what the solution is, but whatever it is I cannot imagine that it does not involve working scientists making choices. What is tenure for, if not allowing senior researchers the independance to do this.
Earlier quoted context omitted.
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
I'm not saying it's an overdose (and their tests of renal and hepatic function corroborate that) But it's not a dose people will commonly take in their "day to day" activities and ideally not something that is done without medical supervision
While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
Six weeks isn't a long time if you've got a herniated disc.
I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
I doubt there is one smoking gun. It's a basket of causes. Too much exposure to weird chemicals, ibuprofen, not enough zinc, obesity, lack of exercise, etc are all causes.
My point here is that it's possible that there are many circumstances accumulating but that doesn't discredit efforts for finding the biggest contributors.
You can easily smuggle a couple of razors between the paper sheets.