Earlier quoted context omitted.
Why are you unable to distinguish it? It is not, a priori, impossible. It is entirely possible that there may be ways to determine if we are in a simulation, depending on how the simulation is done. No simulation is perfect, and it is theoretical feasible to find the imperfections.
To look for imperfections in a simulation requires knowing what the real thing actually looks like. If our universe is a simulation, where do you get the knowledge from what a real universe looks like?
Now, in the end, if we are in a simulation, that simulation (or one of its "parents") is reality, and so effectively we are all bound by the physics of the base reality, so one could argue that there is no harsh line between our simulations' physics and reality's physics, but that's another thread ;)