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FDA Authorizes Ten 23andme Genetic Health Risk Reports

blog.23andme.com

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Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#51

Post by adenadel »

TheSpiceIsLife wrote: post #33
hartator wrote: post #18

Earlier quoted context omitted.

Very few companies even scan your entire DNA. 23andMe analyzes for example maybe less than 1 or 2%.

Presumably most (98% isn't it) of our DNA is the same thought, right? About 98% of our DNA does just makes an ordinary human body with normal systems. So we're only interested in the 2% that can vary . Or whatever the actual numbers are.

It's not that only 2% _can_ vary, it's that each person has about 2% different from the reference genome (and that 2% is different for every single person).

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#52

Post by fudged71 »

sushid wrote: post #14
phkahler wrote: post #6

Is there any way to just have your entire genome sequenced and get all the data in a software-friendly format? At that point there could/should be some open source software for analyzing it and finding common or well understood things like this. That way the software could be updated and people could re-run their analysis to look for newly discovered stuff. I think this would be an awesome amount of fun. I for one wo…

Have you already done a 23andMe analysis? If so, you can check out https://promethease.com/ . It's exactly what you're looking for as they have constant updates that make it worth your while to rescan every year or so.

Why would you need to be rescanned? Does your DNA change that often?

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#53

Post by fudged71 »

dekhn wrote: post #8
phkahler wrote: post #6

Is there any way to just have your entire genome sequenced and get all the data in a software-friendly format? At that point there could/should be some open source software for analyzing it and finding common or well understood things like this. That way the software could be updated and people could re-run their analysis to look for newly discovered stuff. I think this would be an awesome amount of fun. I for one wo…

I did Illumina UYG. As part of that I got a 1TB hard drive with the nearly-raw files (BAM format with raw reads, VCF with variants). Lots of people say " I for one would be interested in looking for certain gene variants that are not mentioned at all over at 23andMe." but they either never do anything with the data, or they look into it and realize that SNP analysis of gene variants is still a charltan's game.

So what did you do with all the data?

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#54

Post by adenadel »

fudged71 wrote: post #52
sushid wrote: post #14

Earlier quoted context omitted.

Have you already done a 23andMe analysis? If so, you can check out https://promethease.com/ . It's exactly what you're looking for as they have constant updates that make it worth your while to rescan every year or so.

Why would you need to be rescanned? Does your DNA change that often?

They mean rescan with the Promethease software. Our knowledge around genetic variation is evolving rapidly.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#55

Post by sushid »

fudged71 wrote: post #52
sushid wrote: post #14

Earlier quoted context omitted.

Have you already done a 23andMe analysis? If so, you can check out https://promethease.com/ . It's exactly what you're looking for as they have constant updates that make it worth your while to rescan every year or so.

Why would you need to be rescanned? Does your DNA change that often?

Not your DNA, but your Promethease analysis can be redone every year or so as they're constantly adding new analyses.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#56

Post by DanBC »

Florin_Andrei wrote: post #43
soneca wrote: post #19

My opinion is that this test is useless at the least and dangerous at the most. It provides information that in almost the totality of the cases no one can correctly interpretate and transform in actionable health advice. Not scientists, not doctors, much less consumers. But it is sold as a cutting edge scientific resource that will improve your life. It wont. Not even increasing the chance that you might avoid somet…

> I believe this test is as good as buying your astrological map Yeah, that's vastly overblown, sorry. Let's say the average for the whole population of getting Disease X is 10% over a lifetime. You do the genetic test, and it turns out you carry an allele that's been shown with good confidence to raise that risk to 30%. What you get is not certainty, of course, but a place in a row of statistical buckets. There are…

> There are studies providing solid evidence that Disease X can be typically delayed by years or decades if you do A, B, and C.

> Is that information not valuable to you?

It depends what A, B, or C are. If it's full mastectomy based on a misunderstanding of statistics then no, that information isn't useful and might be harmful.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#57

Post by fudged71 »

TTPrograms wrote: post #48
soneca wrote: post #19

My opinion is that this test is useless at the least and dangerous at the most. It provides information that in almost the totality of the cases no one can correctly interpretate and transform in actionable health advice. Not scientists, not doctors, much less consumers. But it is sold as a cutting edge scientific resource that will improve your life. It wont. Not even increasing the chance that you might avoid somet…

Thanks to the 23andMe test I found out have I think 6 of 8 rare bad variants of various genes that give me what's currently estimated at around a cumulative 50% chance to develop a particular type of leukemia late in life. Of course, 23andMe doesn't provide this information - I came across it accidentally while studying my SNPs with other third party tools. I don't really think about it that much - experimental treat…

This is the purpose of Genetic Counselling. A friend of mine does this and I can certainly see the value in having someone who understands the science walk you through the outcomes.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#59

Post by contrahax »

phkahler wrote: post #6

Is there any way to just have your entire genome sequenced and get all the data in a software-friendly format? At that point there could/should be some open source software for analyzing it and finding common or well understood things like this. That way the software could be updated and people could re-run their analysis to look for newly discovered stuff. I think this would be an awesome amount of fun. I for one wo…

I wrote some tools for transforming and analyzing your own DNA - http://genomejs.com (Code here: https://github.com/genomejs)

I couldn't find any format that was neutral between vendors, so I wrote something (dna2json) that converts these vendor specific ones into a flat JSON file you can query easily.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#60

Post by Balgair »

fourstar wrote: post #40
Balgair wrote: post #24

Are they still saying that by submitting a sample to them, that they then own your genome and can sell it to whoever they want? I'd love to get mine sequenced and check it out a bit, but not if they are going to sell it off to a million shady companies whenever they go bankrupt (maybe 50+ years, but still)

I ended up canceling my account because of this reason. That and the fact that a bunch of random people started trying to hit me up because apparently we were "linked".

Yeah, that's pretty creepy. Thank you very much for the anecdote and information.
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