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Researchers create gel that regrows tooth enamel (2015)

dentistryiq.com

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Re: Researchers create gel that regrows tooth enamel (2015)

#51

Post by Terretta »

colordrops wrote: post #35
amelius wrote: post #7

This toothpaste claims the same, not sure what to make of it: http://www.smile-store.eu/prevdent-re-whitening-and-enamel-r...

The key is nano-hydroxyapatite. Toothpaste with this ingredient is also sold in Japan.

Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252862/

> "The nano-hydroxyapatite is a revolutionary material with a wide use in dentistry. With regard to restorative and preventive fields, nano-hydroxyapatite has remarkable remineralizing effects on initial lesions of enamel, certainly higher than traditional fluorides used until now for this purpose."

Apagard Premio toothpaste 100g | the first nanohydroxyapatite remineralizing toothpaste -- https://www.amazon.com/Apagard-Premio-toothpaste-nanohydroxy...

Re: Researchers create gel that regrows tooth enamel (2015)

#52

Post by andrewl »

3131s wrote: post #48
stevebmark wrote: post #38

Maybe relevant to someone: Fluoroquinolone antibiotics like Cipro (ciprofloxacin), Levaquin (levofloxacin), *floxacin, etc, directly and maybe permanently increase the production of MMPs, the enzymes this article is talking about. That's (partly) why these antibiotics cause teeth to shatter at the gum line spontaneously. There are something like 40 MMPs and we don't know what they all do, but they're generally respon…

Interesting to see this. In the hazy midst of a spell of bad food poisoning last month, I took the first dose in a course of levofloxacin that a pharmacist had given me. I had begun reading the Wikipedia entry on it before, but right after taking it I came to the section on spontaneous tendon rupture... since I'm an athlete, I freaked out and forced myself to vomit moments later. I'm glad I did. I personally try to a…

Just based on my own experience I never take fluoroquinolone antibiotics. I had one dose of Avelox and the next twelve hours were like a waking nightmare. They were twice a day pills, so I had to wait until that evening for the effect to pass. When I reported the reaction my physician told me to stop the drug immediately. She was quite vehement and sounded alarmed. The experience reminded me of the reaction I'd had to Cipro some years before, but worse. It was then that I looked them up and found they were in the same class.

Now I check. A few months ago I rejected a prescription of Levofloxacin from a new physician, and had him replace it with an antibiotic from a different class that I knew I tolerated well. My pharmacist agreed with my decision. She had taken Levofloxacin for a few days several years ago and it gave her permanent neuropathy in her hip and leg and balance problems. Actually, she said the neuropathy was permanent "so far." For all she knew it would go away, but after three years she wasn't expecting it.

Note that I'm reporting an n of 2 here. My brother says Cipro doesn't bother him at all. Do your research and make your own decisions.

Re: Researchers create gel that regrows tooth enamel (2015)

#53

Post by graeme »

stevebmark wrote: post #47
derefr wrote: post #46

Earlier quoted context omitted.

Not a source, but a corollary of the parent's claim that might be easier to look up: doxycycline, an MMP inhibitor , is used (under the trade name "Periostat") as a prophylactic after dental root planing to prevent damage to the enamel.

Your original question, "what happens if a drug downregulates MMPs" - is a great question and the tip of a largely unexplored iceberg. MMPs are involved in many diseases, including fluoroquinolone insidious poisoning. They are implicated in heart disease and neurological disease like MS, for example. They are also implicated in general aging, because they destroy collagen which is considered to be irreplaceable in th…

Hmm. Took one course of cipro in early 2010. The year after that was the worst of my life health wise. After that, have steadily improved.

I can't say it's cipro related. The stuff that happened was: very bad digestion, chronic left arm pain due to typing in a poor ergonomic position, and a bike accident + broken tooth (this clearly wasn't due to an antibiotic). I did, however, likely acquire MRSA in a wound on my chin that I got during the bike accident (I found out I had MRSA five years later; it had moved to my nose and persisted there at an asymptomatic/occasional flare up level). MRSA seems linked to cipro usage. I also acquired tinnitus at some point, most likely after the bike accident. My liver enzymes also tend to be on the high end of the normal range or slightly above it.

May have started bruxism that year or the one after, but it's hard to date when teeth grinding started. That one could be something that developed after the bike accident.

Nothing necessarily specific to cipro. But, supposing it did contribute to any of that, is there a normal protocol to reverse effects? Beyond what you wrote above, which would be: eat seafood and certain antioxidants (which?)

I'm in a pretty good state right now, and also nowhere near certain Cipro had any impact on me. But, it was a very rough year, and I had always been in excellent health prior to that. So if there's some sort of low side effect thing I could adopt such as certain foods, it's worth trying.

btw, here's the source on cipro and MRSA. I hadn't know about this link: http://www.news-medical.net/news/20120921/Ciprofloxacin-use-...

Re: Researchers create gel that regrows tooth enamel (2015)

#55

Post by toomuchtodo »

fourstar wrote: post #43
stephanheijl wrote: post #13

Is it just me, or does it feel like we've been hearing about advances in dental treatment for decades, without them actually having any effect on the practice? From my personal experience as someone living in the Netherlands, where standards of health care are pretty high, I would expect these advancements to make at least _some_ impact on the field. Instead my (admittedly anecdotal) experience as a patient has been…

You can thank the ADA for that. Novamin is a bioglass that is fortified in Sensodyne, which coats the enamel (a fluoride rival, but better), and was sold to GSK. After that, it suddenly disappeared from shelves in the US. You can still buy it online (it ships mainly from Europe), but not in the stores. It's all one big racket.

At least you can find it on Amazon. Its pricey, but available.

https://www.amazon.com/Sensodyne-Repair-Protect-Whitening-To...

Re: Researchers create gel that regrows tooth enamel (2015)

#56

Post by desireco42 »

Eric_WVGG wrote: post #5
desireco42 wrote: post #2

Finally something to advance dental technology :) I wonder how much existing practices, who are invested in repair and especially cleaning of teeth feel about possibilities to permanently repair teeth. There are other advances such as the one with laser stimulation.

There’s also a new stem cell treatment that could make root canals obsolete. http://www.popsci.com/end-root-canals https://news.ycombinator.com/item?id=12026614

I know about that. It will be years before it becomes available. The only way this will come to market faster is if the emerging market as China or some other country, Japan for example, adopt it and start using it. Japan comes to mind as I heard that they actually try to treat root canals overthere.

Re: Researchers create gel that regrows tooth enamel (2015)

#57

Post by rpedela »

FreeFull wrote: post #37
rpedela wrote: post #27

Earlier quoted context omitted.

Then please don't spread FUD.

Fear, uncertainty and doubt? I don't see how any of that applies to his comment.

1. The original comment was deleted. My comment would make more sense in context.

2. FUD is using false information to spread fear, uncertainty, and doubt. When someone claims nutritional supplements have some sort of miraculous medical benefit, that is FUD. It is FUD because it is almost certainly false information and it helps to create doubt and uncertainty of mainstream medical science.

3. If OP provides empirical evidence that using nutritional supplements regrows enamel, I will admit I was wrong. The wider medical community would also be very interested.

Re: Researchers create gel that regrows tooth enamel (2015)

#58

Post by akanet »

toomuchtodo wrote: post #55
fourstar wrote: post #43

Earlier quoted context omitted.

You can thank the ADA for that. Novamin is a bioglass that is fortified in Sensodyne, which coats the enamel (a fluoride rival, but better), and was sold to GSK. After that, it suddenly disappeared from shelves in the US. You can still buy it online (it ships mainly from Europe), but not in the stores. It's all one big racket.

At least you can find it on Amazon. Its pricey, but available. https://www.amazon.com/Sensodyne-Repair-Protect-Whitening-To...

This is really interesting. Can you cite any research on how effective this variant of Sensodyne is or might be?

Re: Researchers create gel that regrows tooth enamel (2015)

#59

Post by stevebmark »

graeme wrote: post #53
stevebmark wrote: post #47

Earlier quoted context omitted.

Your original question, "what happens if a drug downregulates MMPs" - is a great question and the tip of a largely unexplored iceberg. MMPs are involved in many diseases, including fluoroquinolone insidious poisoning. They are implicated in heart disease and neurological disease like MS, for example. They are also implicated in general aging, because they destroy collagen which is considered to be irreplaceable in th…

Hmm. Took one course of cipro in early 2010. The year after that was the worst of my life health wise. After that, have steadily improved. I can't say it's cipro related. The stuff that happened was: very bad digestion, chronic left arm pain due to typing in a poor ergonomic position, and a bike accident + broken tooth (this clearly wasn't due to an antibiotic). I did, however, likely acquire MRSA in a wound on my ch…

FQs are some of the most powerful antibiotics in terms of destroying healthy gut bacteria, and likely cause permanent gut flora changes after use. Some of the bacteria it destroys are oxygen sensitive, so they aren't in probiotics because they can't survive long enough to be manufactured into a pill.

Muscle problems, especially muscle twitches, are very common among FQ toxicity sufferers. This is suspected nerve damage but there may be other factors.

FQs are well known to cause tinnitus, with the suspected biological mechanism being nerve damage to the ear.

Unfortunately, the medical community is severely lacking in treating these conditions, so there are no reliable tests for determining the underlying damage. It may be impossible to definitively know if any of these things were caused by the cipro.

Re: Researchers create gel that regrows tooth enamel (2015)

#60

Post by stevebmark »

andrewl wrote: post #52
3131s wrote: post #48

Earlier quoted context omitted.

Interesting to see this. In the hazy midst of a spell of bad food poisoning last month, I took the first dose in a course of levofloxacin that a pharmacist had given me. I had begun reading the Wikipedia entry on it before, but right after taking it I came to the section on spontaneous tendon rupture... since I'm an athlete, I freaked out and forced myself to vomit moments later. I'm glad I did. I personally try to a…

Just based on my own experience I never take fluoroquinolone antibiotics. I had one dose of Avelox and the next twelve hours were like a waking nightmare. They were twice a day pills, so I had to wait until that evening for the effect to pass. When I reported the reaction my physician told me to stop the drug immediately. She was quite vehement and sounded alarmed. The experience reminded me of the reaction I'd had t…

If you do your research you will never use fluoroquinolones in your life. The antibiotics can ruin anyone's life, independent of supposed risk factors. Fluoroquinolones have killed many people but there are also many who suffer a permanent, irreversible fate that some consider worse than death. If you do your research you will see the thousands (over 2,000 in 2011 alone) of lawsuits because of these drugs. You will see how these are literally chemotherapy drugs (topoisomerase interrupters). You will see how they are designed to attack almost every cell in the human body, causing a potentially permanent chemical injury that can completely remove any joy of living.

It's important to understand that taking these drugs once without reaction does not mean you are safe taking them again. There are plenty of horror stories of people not experiencing side effects until their 2nd, 10th, etc dose. It's playing russian roulette with death and a living hell. This is not hyperbole, unfortunately.

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