Earlier quoted context omitted.
FWIW, I was an early Homebrew user and even contributed a few recipes, but I moved back to MacPorts because (and no offense to mxcl, but it's kind of unavoidable) the author seems to do things with little understanding of the underlying system or justification. Taking ownership of /user/local is completely utterly pointless and just plain bad advice. Copy-and-pasting optimization code from the Gentoo wiki is pointles…
Just a side note but /usr does not actually stand for /user (although I often pronounce it that way when speaking). It's actually an initialism standing for UNIX System Resources.
When I google I mainly find drive-by assertions that it means "UNIX System Resources" (and sometimes "User Specific Resources"). The closest I can find to something real is:
http://tldp.org/LDP/Linux-Filesystem-Hierarchy/html/usr.html