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Chemical clears Alzheimer's protein and restores memory in mice

nature.com

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Re: Chemical clears Alzheimer's protein and restores memory in mice

#51

Ginkgo Biloba [1] is very solid at helping preventing Alzheimer's, even in some cases slowing it down when it's already occurring. Lots of research on the benefits of Ginkgo. Yet most don't know about it. [1] https://duckduckgo.com/?q=ginkgo+biloba+alzheimer+site%3A.ed...

[deleted]

Re: Chemical clears Alzheimer's protein and restores memory in mice

#52

Ginkgo Biloba [1] is very solid at helping preventing Alzheimer's, even in some cases slowing it down when it's already occurring. Lots of research on the benefits of Ginkgo. Yet most don't know about it. [1] https://duckduckgo.com/?q=ginkgo+biloba+alzheimer+site%3A.ed...

Major studies of ginkgo show minimal, if any, benefits.[1] It has not been proven that there are "very solid" benefits of this substance, thus far.

http://www.mayoclinic.org/diseases-conditions/alzheimers-dis...

Re: Chemical clears Alzheimer's protein and restores memory in mice

#53
post #48

Ginkgo Biloba [1] is very solid at helping preventing Alzheimer's, even in some cases slowing it down when it's already occurring. Lots of research on the benefits of Ginkgo. Yet most don't know about it. [1] https://duckduckgo.com/?q=ginkgo+biloba+alzheimer+site%3A.ed...

https://nccih.nih.gov/research/results/gems

Quotes to save the clicks...

> The dietary supplement Ginkgo biloba was found to be ineffective in reducing the development of dementia and Alzheimer’s disease in older people

> The GEM study—the largest of its kind to date—was a randomized, double-blind, placebo-controlled clinical trial of 3,069 community-dwelling adults aged 72 to 96,

> Compared with placebo, ginkgo did not lessen cognitive decline. Researchers found no evidence of an effect on cognitive decline in general, or on memory, attention, visual-spatial construction, language, or executive functions. There were no differences by age, sex, race, education, or baseline cognitive status.

Re: Chemical clears Alzheimer's protein and restores memory in mice

#54
post #2

Wow, you can buy some EPPS (the chemical in the article) here for £39.20? http://www.sigmaaldrich.com/catalog/product/sigma/54465?lang... Looks interesting research but I'm sure this stuff probably can't be that good for you!

If you use this on someone else with Alzheimer's and they die or are injured, you will almost definitely go to jail. You could likely use it on yourself, but look at it as an extreme, it is still less bad than suicide I suppose... But you don't know what the side effects could be. It kind of scares me that people think they can buy untested chemicals online and self-medicate with them. But then again I'm not into the…

It kind of scares me that people with terminal or completely debilitating diseases don't have widespread access to whatever experimental treatments are available. Imagine watching yourself die and reading articles about promising treatments you are unable to obtain. That is scary.

Re: Chemical clears Alzheimer's protein and restores memory in mice

#55
post #35

Earlier quoted context omitted.

It's amazing to me that people are willing to experiment with an unapproved chemical that provides no proven benefit in humans, yet aren't willing to use human-proven therapies with known benefits such as statins.

Many people are quite cynical about Big Pharma

How many of those people would trade the portfolio of medications available today for those available in 1955?

Re: Chemical clears Alzheimer's protein and restores memory in mice

#56
post #37

Earlier quoted context omitted.

I'm not an expert, but human lifespans have only risen to relevant heights very recently. It's simply not enough time for it for evolution to kick in.

Average life expectancy is a commonly misunderstood (and widely misrepresented) concept. We hear things like "Humans really only lived into their 40s in the Stone Age," or what have you. This is untrue. Average (arithmetic mean) life expectancy was a lot lower because it was heavily skewed by infant mortality. Up until very recently, many more babies died within their first few years of life. We've dramatically impro…

Many more people are living in to their 70's, 80's and 90's than previously in human history. While our lifespan may not have increased much, the proportion of people reaching the extreme ends of our lifespan continues to rise. It's not just about infant mortality (not to mention death from childbirth).

Re: Chemical clears Alzheimer's protein and restores memory in mice

#57
post #54

Earlier quoted context omitted.

If you use this on someone else with Alzheimer's and they die or are injured, you will almost definitely go to jail. You could likely use it on yourself, but look at it as an extreme, it is still less bad than suicide I suppose... But you don't know what the side effects could be. It kind of scares me that people think they can buy untested chemicals online and self-medicate with them. But then again I'm not into the…

It kind of scares me that people with terminal or completely debilitating diseases don't have widespread access to whatever experimental treatments are available. Imagine watching yourself die and reading articles about promising treatments you are unable to obtain. That is scary.

There's a thin line between an experimental treatment with some potential merit being trialed on vulnerable people, and a mad scientist just trying things "to see what will happen."

A lot of terminal people have, historically, had pretty terrible things done to them on the guise of "well they were going to die anyway!"

I for one welcome medical and academic oversight of experimental treatments. Terminal people are especially in need of protection as they will grasp to any hope no matter how slim or misguided.

Re: Chemical clears Alzheimer's protein and restores memory in mice

#58

I am having an epiphany. Maybe this "Alzheimer protein" is supposed to be the brain's defenses to something much worse. Maybe this protein is a "reaction" similar to skin rashes when it absorbs poison ivy's urisol. If Alzheimer was simply a deficiency of nutrients, I wouldn't think this way, but if it really is a protein that "can be cleared", why did it get there in the first place?

I wish I had more time to follow up on this but I'll write what I can think of.

Your core question is a good one and fundamentally raises the question of causality (which came first, the A-beta or Alzheimer's disease, AD? See ref. 1 for a 'simple' discussion).

Interesting evidence comes from people with genetic mutations that decrease the levels of the precursor to A-beta (the protein associated with Alzheimer's plaques). People with these mutations are less likely to develop AD, suggesting that A-beta is related to the root cause of AD. The OP supports this evidence, as removing A-beta plaques ameliorates some memory loss.

As a final, unrelated note, I don't know much dermatology but I haven't gotten the sense that our response to uroshiol is considered protective. Unlike A-beta, uroshiol is directly causative of its associated clinical symptoms[3].

1. http://www.mayoclinic.org/diseases-conditions/alzheimers-dis... 2. http://www.ncbi.nlm.nih.gov/pubmed/22801501 3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC294319/

Re: Chemical clears Alzheimer's protein and restores memory in mice

#59
post #6

it's a great day for mouse health

Relevant West Wing dialog:

MARGARET

Let me ask you this...Red meat has been found to cause cancer in white rats. Maraschino cherries have been found to cause cancer in white rats. Cellular phones have been found to cause cancer in white rats. Has anyone examined the possibility that cancer might be hereditary in white rats?

DR. GRIFFITH

Let me tell you something, I'm not 100% sure we've ruled that out.

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