Earlier quoted context omitted.
"generally people tend to think that macronutrients work independently of each other" Well, that is obviously the wrong idea. Even basic logic speaks against it: people lose weight on keto diet, people lose weight on vegan diet... so neither protein, fat nor carbs can be causing obesity. But what do foods that we know are obesogenic have in common? 1) They are highly processed and/or 2) they combine fats and carbs in…
The big question with such foods is are they worse for you just in and of themselves, or do they tend to promote obesity through inducing people to eat more? For the most part, research seems to suggest that as far as weight gain is concerned, calorie is a calorie (whether from fat, carbs, or protein), but some foods seem to induce people to eat more in general, compared to others. (highly processed and high-sugar fo…
High carbohydrate content causes sugar spikes, which leads to insulin spikes, and insulin spikes both a) cause hunger and b) promote storage of energy in the form of body fat: https://pubmed.ncbi.nlm.nih.gov/3894001/
Second issue is as I said lack of nutrients. Your body needs nutrients, and will force you to eat until nutritional requirements had been satisfied. Since processed foods have very few nutrients, your organism compensates by increasing dietary intake... which means increasing caloric intake.