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GLP-1s are breaking life insurance

glp1digest.com

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Re: GLP-1s are breaking life insurance

#491

Post by neaden »

stego-tech wrote: post #152

Now expand this to other treatments: HIV, PreP, depression/anxiety, ADD, ADHD, you name it. We’ve had data for decades that adherence is the key factor in successfully lowering mortality and increasing quality of life, which in turn increases duration of productive life, which in turn lowers costs in the long run as more people live healthier, longer, more productive lives. The problem continues to be the pharmaceuti…

I don't think this is addressing the thrust of the article, which is that Life Insurance companies are getting "fooled" by patients who on paper are healthier then they are in reality. Someone on PreP to prevent getting HIV is as healthy on paper as they are in reality as far as I can see.

Re: GLP-1s are breaking life insurance

#492

Post by neaden »

hiAndrewQuinn wrote: post #58
lesam wrote: post #12

Earlier quoted context omitted.

Aren’t “Big Life Insurance” and “Big Annuity” pretty much the same companies?

They are, they're basically mathematical inverses of the same product. Big Annuity can charge you more, in fact, if it has reason to believe you're going to live unusually long, so playing the GLP-1 dance with them would only be profitable in reverse. Pretend to be the unhealthiest person on the planet, lock in an annuity, then get on the drip stat.

I think the difference is people generally get Life Insurance when they are younger (I'm guessing frequently when they have kids, that is when I got it at least) but get Annuities when they are a senior. I don't know anyone my age who is purchasing an annuity now, though I suppose there must be someone who would be willing to sell it.

Re: GLP-1s are breaking life insurance

#493

Post by s1artibartfast »

AbstractH24 wrote: post #426
jtrn wrote: post #226

Earlier quoted context omitted.

For semaglutide, the newest and most potent GLP1. United States: The main patent is expected to expire around 2032. Monthly Price: $950 - $1,350+ (cash price without insurance) Norway: The main patent is expected to expire around 2031. Monthly Price: $109 - $301 (cash price equivalent in USD)

> United States: The main patent is expected to expire around 2032. Monthly Price: $950 - $1,350+ (cash price without insurance) While 2032 seems very far away now, its actually remarkably soon in the grand scheme of society. My understanding is one of their defendable moats is the patent not on the compound itself, but on the injectors. Which is far longer.

where do you get that?

There are dozens of autoinjector manufacturers, and generics can and do change manufacturers. It looks like semaglutide uses an off the shelf Yposomate pen, although Novo Nordisk uses different injectors depending on the country and indication.

Novo Nordisk also has an in house pen, but this would not prevent someone from competing, unless patients simply prefer that design to a generic one.

Re: GLP-1s are breaking life insurance

#494

Post by s1artibartfast »

thephyber wrote: post #490
AbstractH24 wrote: post #426

Earlier quoted context omitted.

> United States: The main patent is expected to expire around 2032. Monthly Price: $950 - $1,350+ (cash price without insurance) While 2032 seems very far away now, its actually remarkably soon in the grand scheme of society. My understanding is one of their defendable moats is the patent not on the compound itself, but on the injectors. Which is far longer.

Yeah, the drug + the injector together are the patentable thing. When the first patent nears expiration, they work on an iteration of the injector or a time release change for the drug, then they get another few decades of product monopoly. They have also made a business of either stifling or “catch and kill”ing of the generics for their products. It’s cheaper to pay off a generic manufacturer to not compete with the…

This is not correct. New patents cover the new combination, but don't prevent practice of the old combination

Re: GLP-1s are breaking life insurance

#495

Post by LitFan »

SirMaster wrote: post #476
nerevarthelame wrote: post #120

Earlier quoted context omitted.

This is akin to saying a severely anxious person should be able to take an SSRI for a few months, learn how to change their thinking, and stay off antidepressants for the rest of their life. So simple. Must be their fault if they can't pull it off. Perhaps that works for some people. I'm glad it seems to have worked for you. But the facts of the world we live in show that it doesn't work for most. "Learn the lesson a…

You think that controlling your anxiety and controlling what you put into your mouth are equal things? I would say that controlling what you put into your mouth is easier than controlling your anxiety.

I would say that in at least some cases over eating and anxiety are both symptoms of underlying problems. Stress, emotional issues, and trauma can all lead someone to either of the two.

As someone that uses food as a coping mechanism for stress, I agree with the GP - if the underlying problem isn't resolved, the weight will come back.

Re: GLP-1s are breaking life insurance

#496

Post by firesteelrain »

busterarm wrote: post #467
firesteelrain wrote: post #126

Earlier quoted context omitted.

From what I understand you don’t have to be obese and have type 2 diabetes. In my case, I was obese and did not have diabetes but I might have been going down that road

A lot of skinny people with a family history of diabetes find that they can become diabetic/pre-diabetic as they age. The trick to avoid it is to put on muscle mass, which regulates your blood glucose levels.

Thank you. I will keep monitoring my A1C and lifting weights

Re: GLP-1s are breaking life insurance

#497

Post by jstummbillig »

firesteelrain wrote: post #258
jstummbillig wrote: post #154

Earlier quoted context omitted.

I mean no offense, but you have a fairly substantiated body of evidence that something in the medication is causing the weight loss. The side effects do sound really shitty though.

It makes you feel less hungry. It doesn’t burn fat. Eat less + exercise = weight loss

I am aware of the mechanics, thanks.

Re: GLP-1s are breaking life insurance

#498

Post by droopyEyelids »

firesteelrain wrote: post #409
const_cast wrote: post #405

Earlier quoted context omitted.

> In order for me to gain all that weight back, I would have to eat a ton of calories per day and completely stop moving/exercise. Yes, this is what usually happens. You've spent far, far more time with those calories than without. > It’s been nearly a year Okay, that's not a very long time is my point. It's much too early to think it's over. I'm not saying that it's not possible to get off GLP-1s and maintain a good…

Okay will report back in one year.

First off I just wanna say awesome and I send positive energy to you and you’re gonna do great.

But then I just wanna talk about how long life is in terms of weight gain! Even two years is an “short” amount of time!

Last month, I looked over my doc where I keep track of my weight and I’ve been gaining about 1 pound a year since I started tracking it… 20 years ago. That’s a significant amount and I maybe have 30 years left to go! (this comment is not about you specifically, just musing on how long life is in terms of weight gain)

Re: GLP-1s are breaking life insurance

#499

Post by arp242 »

romaaeterna wrote: post #299
arp242 wrote: post #241

Earlier quoted context omitted.

Well, don't say you weren't warned when it turns out the miracle is not such a miracle after all and it all massively backfires in a few decades, at which point you're still going to have to actually fix the real underlying causes.

The class of drugs having a 2+ decade negative health effect greater than the negative health effect of obesity over the same period, without any obvious short-to-medium health effect, is likely to be small.

For obese people: probably. The overall health benefits for overweight people are a lot less clear. Being merely overweight (rather than obese) is not that strongly associated with negative health effects.

Look, I hope you're right. If in 20 years time we look back at these comments and no negative effects have manifested then I'll happily buy you a beer to celebrate. Hell, I'll buy you an entire crate of beer. But I think this is one hell of a risk to take.

Re: GLP-1s are breaking life insurance

#500

Post by NoMoreNicksLeft »

gscott wrote: post #318
raldi wrote: post #280

Earlier quoted context omitted.

Then wouldn’t the government want to subsidize it?

Elon Musk suggested it. The fast food Industry has ppl addicted along with the lack of health education in schools.

The effectiveness of "health education" is somewhere between extraordinarily modest and nonexistent. It's not that people don't know what's healthy, it's that when it comes time to resist compulsion that is difficult, uncomfortable, and undesirable.
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