"Big Pharma" in the eyes of the public is two related but separate issues; 1) the weird employment-insurance-hospital loop that has developed in the US, and the terrible second-order-consequences of all the open-high/settle-low insurer carer system it led to, and 2) the medicine advertisements, and all the terrible consequences thereof. The second one seems like a much easier thing to get rid of using hard government…
There is also a third issue: The high cost of medicines that are low cost to produce, and are sold at low cost elsewhere
That relationship between those three parties is the root cause of the messed up incentive model responsible for the ridiculously high costs of all products/services in US healthcare; pharma included.