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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#481

Post by Etheryte »

crazygringo wrote: post #371
Etheryte wrote: post #298

Earlier quoted context omitted.

Many foods and beverages include ingredients whose sole purpose is to hide how sweet it is because otherwise it would be unbearable in your mouth. Gives you a stronger high once it reaches your stomach though.

I don't know where you got that information, but no they don't. That's not a thing. You were misinformed.

What do you mean no? This is a widely known and commonly used approach. Citric acid, salt and bitter compounds are some of the most prevalent options. This isn't even remotely close to a controversial opinion.

Re: GLP-1 drugs: An economic disruptor? (2024)

#482

Post by novok »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

There is a segment of people where GLP-1 medications just don't work, 68% stop within a year, and dosing keeps on escalating up and up. It will help a lot of people, but it is not going to be the panacea early results show.

Re: GLP-1 drugs: An economic disruptor? (2024)

#483

Post by mac-mc »

ragazzina wrote: post #274
crazygringo wrote: post #225

Earlier quoted context omitted.

I'm curious -- do you have any brain fog? Are you able to exercise? When you exercise, do you wind up eating more, i.e. the caloric amount that you exercised? I've never had any psychological difficulty with losing weight. I don't care if I'm hungry. But what happens when I eat less and lose weight is that I have trouble concentrating. The glucose my brain needs just isn't there. And if I do physical activity, forget…

> But what happens when I eat less and lose weight is that I have trouble concentrating. The glucose my brain needs just isn't there. This is crazy, I have the completely opposite effect. On keto + calorie restriction I feel much more alert and sharp.

It's because people are different, sometimes on a genetic level. What works well for one person does not work well at all for another, like the parent commenter, I do not work well without carbs. Keto puts me in a low-energy, semi-depressed state, while eating +80% of my calories as starch led me to lose about 15lbs of fat and now I'm the lowest body fat % I've ever been in my adult and teen life and my HOMA-IR went from 3 to 1.6!!!!

And my genetics also showed this to be the case too!

Re: GLP-1 drugs: An economic disruptor? (2024)

#484

Post by glp1guide »

YokoZar wrote: post #471
glp1guide wrote: post #426

Earlier quoted context omitted.

Sorry a bit late here, but both Tirzepatide and Semaglutide are off the shortage list, and the promise to not seek legal action that is currently allowing some compounders to operate freely will likely end sometime soon. Literally, the only reason any compounder today (that is brave enough) can produce Tirzepatide or Semaglutide is because the FDA has promised to not pursue legal action for a short period to enable p…

Sure, but shouldn't we expect this to reverse again when it goes out of patent, at least for Ozempic?

Absolutely! Timing on that is not so great though:

https://glp1.guide/content/patent-expirations-for-glp1-recep...

Again this is not great news but if you zoom out it’s amazing that obesity might be a solved problem basically completely in like 10 years.

Obviously GLP1s don’t work for everyone but they work for a lot of people, maybe we can focus the remaining resources on a smaller group of people with greater struggles

Re: GLP-1 drugs: An economic disruptor? (2024)

#485

Post by esseph »

WaxProlix wrote: post #414
esseph wrote: post #390

Earlier quoted context omitted.

My wife was on daily doses and it made no difference. She's now having long-term problems, over a year after getting off of it.

What side effects/problems are you referring to?

Non-stop nausea and uncontrollable vomiting every day since. She's been to numerous doctors and even got her stomach scoped.

https://time.com/7130456/ozempic-side-effects-wegovy-mounjar...

Re: GLP-1 drugs: An economic disruptor? (2024)

#486

Post by submeta »

crazygringo wrote: post #229
submeta wrote: post #118

Big food corporations profit from ultra-processed foods that manipulate our natural systems. They design products that override satiety signals using calculated combinations of sugar, fat and salt to activate brain dopamine pathways. Their priority is profit growth, not consumer health. The consequences are significant health issues like obesity, diabetes and cardiovascular diseases. Healthcare systems struggle with…

> Big food corporations profit from ultra-processed foods that manipulate our natural systems. I've just never bought this. Does grandma manipulate you when she adds sugar to her cherry pie? Does she manipulate you when she adds salt to her mashed potatoes? Foods -- "ultra-processed" or not -- don't "manipulate" you. They literally just either taste better or taste worse. Grandma, and her grandma before her, used sug…

Do you go to grandma every day to eat calory packed food? Does grandma deploy dozens of scientists who design food so that it has an addicting effect? Dozens of marketing experts who confront you with images to consume the junk? Lobbyists who try to convince that sugar is not causing health problems? Your analogy does not work. These corporations are creating products that cause massive health issues that cost society billions.

Re: GLP-1 drugs: An economic disruptor? (2024)

#487

Post by submeta »

wakawaka28 wrote: post #256
crazygringo wrote: post #229

Earlier quoted context omitted.

> Big food corporations profit from ultra-processed foods that manipulate our natural systems. I've just never bought this. Does grandma manipulate you when she adds sugar to her cherry pie? Does she manipulate you when she adds salt to her mashed potatoes? Foods -- "ultra-processed" or not -- don't "manipulate" you. They literally just either taste better or taste worse. Grandma, and her grandma before her, used sug…

Yeah it's anti-capitalist rants at every turn around here. Capitalism is the best system we have to make people happy in a fair way. It's not a system to teach people the benefits of moderation or charity. You're supposed to bring that to the table yourself. There's no economic system in the world that can fix character flaws.

Yeah, lets sell cigarettes and blame consumers for health issues because, you know, capitalism is the best system we have and the burden is on the consumers.

Re: GLP-1 drugs: An economic disruptor? (2024)

#488

Post by PeterStuer »

crazygringo wrote: post #225
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I'm curious -- do you have any brain fog? Are you able to exercise? When you exercise, do you wind up eating more, i.e. the caloric amount that you exercised? I've never had any psychological difficulty with losing weight. I don't care if I'm hungry. But what happens when I eat less and lose weight is that I have trouble concentrating. The glucose my brain needs just isn't there. And if I do physical activity, forget…

Your muscle repair would come primarily from protein. I used to train quite intensely and this protocol worked for me (timings matter):

- 45 mins before workout: small bowl of oatmeal with milk

- 30-0 mins before workout start: 1 liter of water pre-hydration

- During workout: 1/2 liter of water per half hour of intense cardio training, less so for resistance

- Straight after workout: double black espresso coffee (high caffeine)

- Hit sauna for extensive slow cool-down, drinking one sports drink (sugars and electrolytes)

- hour later: full meal of mainly lean protein

Never had issues with muscle pains or "fog".

If you go really deep beyond your usual sustain, feeling physically exhausted and needing rest afterwards is normal. Eating your way through it is not the way to go.

Re: GLP-1 drugs: An economic disruptor? (2024)

#489

Post by machomaster »

gcanyon wrote: post #388
machomaster wrote: post #196

Earlier quoted context omitted.

The issues with "too quickly" are: 1. the loss of muscle mass 2. low energy 3. unnecessary suffering 4. high fatigue 4.1. inability to maintain the low calorie diet for long enough 4.2. relapse; jojo-dieting. 1, 4.1 and 4.2 are the biggest problems.

1. I can't speak to that, no analysis here and the time frame (the low carb thing was back around 2008) is too long for meaningful comparison. 2. Maybe? For normal things, not really, but when I try to row for an hour I feel it. I definitely get cold more easily. 3. I'm not built that way. The low carb thing was completely annoyance-free. As I said, the goal there wasn't weight loss, but raising my HDL; the weight li…

I was answering a general question, not talking about you/diet specifically.

It's generally recommended to:

- do heavy resistance training

- losing fat at the rate of 0.5-1% of a body weight a week

- do it for 8-12 weeks

- (critical) after which to have a maintenance phase with a duration of 2/3-1 length of the dieting phase

- after that can do another dieting phase again.

- repeat as many times as needed.

- if wishes to build muscle/bulk, should do it 4 times slower than dieting. So 250g-1kg weight gain a month.

Re: GLP-1 drugs: An economic disruptor? (2024)

#490

Post by throw-qqqqq »

teleforce wrote: post #57

>Consider this: When alcohol consumption drops 40% (as it does for many people on these medications), we're not just talking about lower beer sales. We're talking about: Apparently in most muslim households this drops to 100% or zero consumption, you don't need freaking drugs for that

Hah, Breatharians can do way better than that!

https://en.m.wikipedia.org/wiki/Inedia

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