Earlier quoted context omitted.
Is there a drug I can take to gain weight?
mj
What's mj?
Ozempic shows anti-aging effects in trial
471–480 of 868 posts
Re: Ozempic shows anti-aging effects in trial
#472Re: Ozempic shows anti-aging effects in trial
#473Earlier quoted context omitted.
Is there a drug I can take to gain weight?
Gaining weight works by putting more fuel into your body than you use. That's physically the only way, there is no way to synthesize energy. Because of caloric density limits, there is no substitute for putting a certain amount of stuff in your body. A pill can physically not contain enough calories. There are options around that, but that depends on what's driving your personal energy deficit. What's the job that th…
> A pill can physically not contain enough calories.
No, but a pill can make you want to eat more or fidget less etc.
Re: Ozempic shows anti-aging effects in trial
#474Earlier quoted context omitted.
I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.
There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…
> Skinnier countries aren't skinnier because the people there have more willpower, it seems, but because they live in a skinnier country and are surrounded by the culture, laws, physical layouts of the created world, et c., that come with that.
Do we have data on that?
I guess you could look at natural experiments, like people who lost and won H1B lotteries, and see if only the ones actually making it to the US get fat?
Re: Ozempic shows anti-aging effects in trial
#475Earlier quoted context omitted.
I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…
The skepticism people have towards metabolic dysregulation models of obesity is too much. We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant…
> Obviously she broke her metabolic system and she obviously did it through diet.
No, she picked up a mental behavioral disorder that has nothing to do with her metabolism.
Re: Ozempic shows anti-aging effects in trial
#476I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…
There's also a horseshoe effect here. At the other end are people who advocate for fat acceptance and see the GLP-1 drugs as another source of pressure to be thin. (Not everyone can take semaglutide etc without unpleasant side effects).
Re: Ozempic shows anti-aging effects in trial
#477I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…
I have a friend using it and he said the worst thing (for him, he didn't have nausa/constipation/etc) is that food is not enjoyable anymore. He says he feels hungry, eats, doesn't feel full but doesn't want to eat anymore.
If he overeats he said he feels kinda bad (with heartburn the next day).
Re: Ozempic shows anti-aging effects in trial
#478Earlier quoted context omitted.
However, amphetamines such as Adderall were also sometimes prescribed for weight loss. I'm surprised it was done so rarely before Ozempic was a thing. They were quite effective.
The side effects of adderall are pretty bad. If I'm on a dose that's high enough to suppress my appetite, then I get a very bad crash in the evening. I start to feel like if I want to enjoy life after work, I need to take another adderall to feel normal. That disrupts sleep, and then things start to get really bad.
This varies from person to person, but the effects mentioned above have been my personal experience as well.
Re: Ozempic shows anti-aging effects in trial
#479Earlier quoted context omitted.
And also the idea that it is "easy" to lose weight is completely out of touch. If it was there wouldn't be millions of people trying hard, spending money on trying and failing for decades, and entire businesses addressing that. RFK Jr's "let them eat less" is paradoxically the modern version of "let them eat cake"!
> And also the idea that it is "easy" to lose weight is completely out of touch. If it was there wouldn't be millions of people trying hard, spending money on trying and failing for decades, and entire businesses addressing that. This is a touchy topic, but I would like to point out that you're missing the obvious confirmation bias that comes with this observation. There are many people who modulate their weight by c…
The selection bias also works for genetics. For me, it's basically impossible to become fat.
Re: Ozempic shows anti-aging effects in trial
#480I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…
> if it would improve the evolutionary fitness of the majority of people
Evolution led to the intelligence that led to creating Ozempic. Maybe that's the mechanism by which evolution is improving evolutionary fitness. The idea that what was created by man is not part of evolution is part of the naturalism fallacy; it's the false belief that the domain of nature stops at the doors of the lab.