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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#471

Post by YokoZar »

glp1guide wrote: post #426
jijji wrote: post #394

Earlier quoted context omitted.

how so? the last i checked, the prices are going down, not up (from the biolabs that manufacture the peptides)

Sorry a bit late here, but both Tirzepatide and Semaglutide are off the shortage list, and the promise to not seek legal action that is currently allowing some compounders to operate freely will likely end sometime soon. Literally, the only reason any compounder today (that is brave enough) can produce Tirzepatide or Semaglutide is because the FDA has promised to not pursue legal action for a short period to enable p…

Sure, but shouldn't we expect this to reverse again when it goes out of patent, at least for Ozempic?

Re: GLP-1 drugs: An economic disruptor? (2024)

#472

Post by ReptileMan »

KaiserPro wrote: post #73

I would point out that it isn't unforeseen, given that genz don't drink, go out or do drugs to anywhere near the extent that millennials did at the same age. ( https://www.statista.com/chart/30783/alcohol-consumption-by-... ) I would also gently point out the evidence for tempering alcohol only seems to be evident with people who have high BMI https://www.pulsetoday.co.uk/news/clinical-areas/mental-heal... So yes, it…

>I would point out that it isn't unforeseen, given that genz don't drink, go out or do drugs to anywhere near the extent that millennials did at the same age

Kids these days

Re: GLP-1 drugs: An economic disruptor? (2024)

#473

Post by cm2187 »

__turbobrew__ wrote: post #467
cm2187 wrote: post #210

Earlier quoted context omitted.

I am 8 months in, you do develop a tolerance over time to the drug (and why you need to increase the dosage progressively). I have gone up slower than the prescibed steps but still, this drug is to help doing diets, I don't think it would work as a long term medication. And as far as I can tell, when you get off the drug or have become tolerant to the current dosage, it is easy to gain back some weight if you are not…

Interesting, what is the end game then if you need to be on the drug to keep the weight off but you also develop resistance to it over time? I wonder how the body reacts after being on the drug for years at a time and then you cut it off, are the cravings stronger than before you started the drug?

Doesn't mean you go back all the way up. And I don't know if the resistance wears off if you stop taking it. What I am hoping is to end up in an end state where I can keep the weight within a 5-7kg range and go on the drug for 2-3 months once a year to go back to the bottom of the range.

I think the craving is primarily a function of how much your stomach expects food, ie the more food the more craving, but also you can get it used to a lower regime. And to external factors like stress, tiredness, cold, etc.

Re: GLP-1 drugs: An economic disruptor? (2024)

#475

Post by aenis »

wert7886 wrote: post #469
aenis wrote: post #463

Earlier quoted context omitted.

Awesome stuff. Envious, here (NL) its impossible to get a prescription. For an alternative approach for comparison: My wife and I eat low carb and fast every other day for a year now. Around the 2nd month mark we got the exactly same outcome: food became a chore. We sometimes dont eat for 2-3 days when travelling or busy. I dont remember feeling hungry in about a year. We do sports - I sure have less peak power, but…

That sounds very intriguing, are you a bit concerned about the dropping vo2max ? Do you eat a lot more meat than before?

No, I eat a lot less in general and a whole lot of veggies.

I followed the same routine 4 years ago, then I stopped and when I started eating carbs my vo2max recovered overnight. I think one cant have it all - either you run on stored energy which caps the power to weight ratio - or on readily available glucose and glycogen. Its fine, I am not an athlete, I do sports to feel good. I dont see an impact on raw strength - just on anaerobic performance.

Re: GLP-1 drugs: An economic disruptor? (2024)

#476

Post by raincom »

tasty_freeze wrote: post #93
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I resonate with your comment about appetite loss. It is surprising how much it has affected my happiness, to have this few times a day pleasure taken away. A month ago I suffered through a norovirus infection, the first time for me. In three days I lost six pounds (my BMI is 21.2 now). At first I wasn't surprised or worried -- after all, I had emptied out my digestive tract and was dehydrated. But a month has gone by…

Maybe, Norovirus affected GIP and GLP-1 hormones. This could be a new research avenue for weight loss. GIP and GLP-1 are product of the research about the Gila monster lizard, which eats three or four times a year and survives.

Re: GLP-1 drugs: An economic disruptor? (2024)

#477

Post by andbberger »

ascorbic wrote: post #468
andbberger wrote: post #423

Earlier quoted context omitted.

name some nations that maintain healthy weight without drugs? your dogma isn't supported by the data. obesity is a public health problem and it's not caused simply by junk food

Japan and South Korea. Much of southern Europe. It depends how you define healthy, but most of Europe has obesity rates below 20%. And that's just if you're counting rich countries.

japan https://data.worldobesity.org/country/japan-105/#data_trends

south korea https://data.worldobesity.org/country/south-korea-114/#data_...

spain https://data.worldobesity.org/country/spain-199/#data_trends

greece https://data.worldobesity.org/country/greece-80/#data_trends

Re: GLP-1 drugs: An economic disruptor? (2024)

#478

Post by slicerdicer2 »

dhfbshfbu4u3 wrote: post #408
BandButcher wrote: post #393

Earlier quoted context omitted.

no Just-In-Time crispr gene editing as the cherry on top??

Nope. Just stuff they can use right now. No magic required!

GLP-1s have high quality double blinded placebo controlled RCTs proving them.

Does anything else you mentioned?

Re: GLP-1 drugs: An economic disruptor? (2024)

#479

Post by worik »

> Analysts predict that by 2030, 30% of American adults will be on these medications,

What on Earth are Americans doing to themselves?

I understand that ic certain cases these drugs may be useful, but as a replacement for proper food and health care?

Eat better, move more, it sounds like a full blown systemic health crisis

Re: GLP-1 drugs: An economic disruptor? (2024)

#480

Post by Earw0rm »

TechDebtDevin wrote: post #461
wakawaka28 wrote: post #270

Earlier quoted context omitted.

It will probably fuck up your body in ways that we can hardly imagine. Ozempic has been linked to lots of horrible side effects.

Its saved or extended 1000 lives for every one person whos gotten some GI stress from it.

That says T2D is bad (indeed, arguably a lot worse than popular understanding), not GLP-1's are candy.

Have to wonder if people really understood the consequences, would they still allow themselves to get in that state? Then again, used to be that smoking was something 1-in-3 did, so...

Anyway, seems pretty settled that fixing T2D with GLP-1's is a lot less harmful than not, but using them on healthy people is a different story.

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