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What Ozempic does to the gut-brain axis

psychologytoday.com

461–470 of 555 posts

Re: What Ozempic does to the gut-brain axis

#461
post #428

Earlier quoted context omitted.

People are different. Weird, right? I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it". I'm not like that. Leaving half a burger that I paid for on the plate is something I've never done or even conside…

Same. College nutritionist: "I'm going to give you the opposite advice of everyone else. If you can add butter to something, do it." Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height. I guess the easiest way to describe my subjective experience is that the "You're hungry, eat" audio channel is turned waaay down in my brain,…

>Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

You probably move much less than you used to. Metabolism slowing down with age is already known.

Re: What Ozempic does to the gut-brain axis

#462

Earlier quoted context omitted.

If you want the real answer, people suck at shopping for groceries and don't know how or want to cook. Long before LLMs, there was a different but similarly misguided hype around making food more convenient. Making money off ignorance is not "innovation", but we live in a world convinced by arrogant and pretentious fearmongering liars. As always, just do it yourself. It's not that hard after all.

If it "wasn't that hard", obesity rates would be much lower.

obesity rates are lower in tribal population who still live active life.

Re: What Ozempic does to the gut-brain axis

#463
post #265

Earlier quoted context omitted.

People can get fat by eating too much healthy food.

Not really the fiber and stuff is normally too filling

It is for some people, it's not for some other. I could get overweight overeating carrots and lettuce if I was not controlling myself constantly.

Re: What Ozempic does to the gut-brain axis

#464

Earlier quoted context omitted.

I think you are ignoring the selection bias, when looking at people who seek out professional help for losing weight, even more so when it's about people who can then become jacked. Note that I'm not speaking as someone who has just accepted being overweight/obese. I was hovering around 105kg in my early 20s, then I gathered the motivation to go down to ~75kg over the course of a year, then maintained myself around 8…

A lot of us with mesomorphic physiques (I am not an ex-football player but my dad played for Syracuse in the The Express era) can be very physically active and muscular but still pretty fat. Lots of us have metabolic syndrome and heart trouble (my dad died in an accident, but all my uncles have received stent and stent, i'm hoping being proactive with medication et. al will head that off in my case) Yeah I know bodyb…

>but my dad played for Syracuse in the The Express era

People in pro sports take PEDs.

>can be very physically active and muscular but still pretty fat.

you can retain higher muscle mass at higher bodyfat% like Sumo Wrestler.

being lean limits amount of lean mass you can carry.

>Yeah I know bodybuilders manage to get jacked and many of them are doing nothing

bodybuilders who take PEDs do not easily gain fat because steroids change nutrition partitioning.

also, some bodybuilders take DNP, clen, t3 etc... but many bodybuilders also do hours of zone2 cardio.

Re: What Ozempic does to the gut-brain axis

#465
post #21

Earlier quoted context omitted.

Why not? People take depression meds, blood pressure meds, all kinds of meds for their whole life. I'll be on omeprazole for reflux my whole life. It doesn't solve the underlying problem of my gut being prone to overpumping acid into my stomach. So omeprazole is problematic? The underlying issue is being treated, it's treated by taking the drug. It works. It's doing its job. I'd be curious as to how you came to this…

Because it's pretty likely some of these have negative long term effects. And some of those long-term effects are probably pretty serious. Many people taking these kind of drugs are gambling with their well being. No doubt that in many cases that gamble is worth it. But issues that can be solved with non-pharmaceutical solutions, such as with weight loss and lifestyle changes, are really better solved that way if pos…

The gamble is not taking it for overweight ppl that hope the consequences of being overweight/obese are less bad than theoretical consequences of glp1

Re: What Ozempic does to the gut-brain axis

#466
post #265

Earlier quoted context omitted.

What if you could intentionally eat good food? I've heard it widely described as reducing mental noise around food.

People can get fat by eating too much healthy food.

I consumed +11lbs (5.1kg) of food yesterday for only 2,500kcal

If you have a stomach and appetite that are capable of consuming the 15 to 20 lb you need to eat 3,500 to 4,000 calories of similar foods, you ought to call a research lab

Re: What Ozempic does to the gut-brain axis

#467

Earlier quoted context omitted.

true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense. Eating healthy food alone isn't solution, you need to make your life active as well.

The glycemic index also comes into play. It essentially measures how much certain foods keeps you full regardless of calories. So healthy food, even if you’re consuming the same calories as junk food, is going to keep you full longer.

Sorry but isn’t GI about how “sugary” a food is…? I don’t believe it doesn’t measure to do how full you feel.

https://www.verywellhealth.com/glycemic-index-vs-load-521436...

Re: What Ozempic does to the gut-brain axis

#468

What’s the downside to this magical drug. There has to be a downside…

Long-term downsides tend not to show up in studies for many years. For example, these drugs might increase cancer rates, but we wouldn't know for a few decades.

I imagine though that on-balance they'll be net positive because being overweight is just so bad for you.

Re: What Ozempic does to the gut-brain axis

#469
post #428

Earlier quoted context omitted.

Same. College nutritionist: "I'm going to give you the opposite advice of everyone else. If you can add butter to something, do it." Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height. I guess the easiest way to describe my subjective experience is that the "You're hungry, eat" audio channel is turned waaay down in my brain,…

>Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height. You probably move much less than you used to. Metabolism slowing down with age is already known.

I'm not running cross country anymore, so that's about 10 miles less a week on my knees. ;)

Re: What Ozempic does to the gut-brain axis

#470
post #431

Earlier quoted context omitted.

If your biology is working against you, why not fix your biology? I'm not someone who needs to take GLP-1 receptor agonists, but if I had any issues with weight then I'd have no issue taking them life-long. The long-term health benefits are already strong enough to make it a no-brainer. If you are overweight and a GLP-1 drug helps you lose that weight, you will very likely live a longer, healthier and happier life by…

If the food abundantly available is full of unhealthy ingredients and nutrient combinations meant to make you addicted, why not fix that ? We blame biology and people’s willpower a lot , instead of considering how plenty of other or previous societies don’t/didn’t have this issue.

The former isnt something an individual can change on their own
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