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Ticker: Don't die of heart disease

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Re: Ticker: Don't die of heart disease

#451
Hey, just a friendly reminder that this is HackerNews, not The Lancet.

I have seen past comments here debating many relative basic concepts on medicine. Please don't take medical advice from engineers. Drink water, exercise, eat well. Otherwise seek medical advice from a doctor.

Thanks!

Re: Ticker: Don't die of heart disease

#453
post #326

Earlier quoted context omitted.

GLP-1s are remarkably effective.

Absolutely true, but it seems there is a lot of reluctancy in prescribing them

I'm not sure that's true? Insurance is hesitant to cover their expense for less extreme cases, and they're very expensive. But I haven't heard of prescribing being a real bottleneck. They're not controlled substances and the side effect profile is pretty mild (other than price).

Re: Ticker: Don't die of heart disease

#454
post #81
post #69

Earlier quoted context omitted.

> lots of variety of veggies and fruits, little meat This is wrong. Our bodies evolved to rend flesh and eat meat. They are optimized by millions of years of evolution to process and run on meat. The biochemical pathways of carb-heavy diets put more oxidative stress on the body.

This is wrong. Our bodies evolved to eat a diverse omnivorous diet and complex carbs + the antioxidants present in vegetables and fruits are anti-oxidative.

>Our bodies evolved to eat a diverse omnivorous diet and complex carbs

Evolved to eats omnivorous diets yes no doubts, but to thrive on omnivorous diets, perhaps no. Most people I know thrive on meats and do worse otherwise.

Re: Ticker: Don't die of heart disease

#455
post #267
post #206

Earlier quoted context omitted.

You may have missed the stat that 30% of the population that’s the median of will die of heart disease. You don’t want to be at the median.

100% of the population will die of something. If I die at 90 of a heart attack havjng maintained the ability to live independently up until then, I’d take that as a massive win compared to my relatives suffering through a decade of me with worsening dementia.

Cardiovascular diseases are huge risk factors for dementia, so if your goal is to avoid dementia you should try to have a healthy cardiovascular system.

Re: Ticker: Don't die of heart disease

#456

> All of these can be accessed through bloodwork and urinalysis and can be done at a local Quest Labs (I’d venture to bet there’s one within a 10-mile radius of your home), prescribed by your doctor, and will likely cost anywhere between $80-$120 out of pocket. A frustrating thing about this suggestion -- if I tell my physician (I live in the US) that I want these unusual tests prescribed, s/he would scorn at me (as…

> 'mycin' means it's Penicillin-variant, which is usually used to treat bacterial infection

This isnt even remotely correct. Penicillin is derived from a fungus, the -mycin antibiotics are derived from various Streptomyces bacteria.

Re: Ticker: Don't die of heart disease

#457

Anyone note where to get this full blood panel done in the UK? I’ve got issues with high blood pressure and swelling in the lower extremities. Blood tests and ECG showed nothing. Both granddads died in their 50s from heart attacks. I’m convinced I have an issue with my circulation but the blood tests I had done doesn’t seem to cover everything stated here.

> I’ve got issues with high blood pressure and swelling in the lower extremities

Edema in the lower legs is a relatively common side effect of some types of blood pressure medication. If you are on BP medication, talk to the prescribing doctor about it.

If you aren't on medication, you should discuss starting something with your doctor. High blood pressure is a risk factor for many things you dont want to happen and is very treatable. (Of course, the standard health advice to improve your diet and exercise more very much applies here as well).

Re: Ticker: Don't die of heart disease

#458

Earlier quoted context omitted.

The other thing these number chasers don’t tell you is that extremely low LDL numbers are also associated with anger management issues. The stuff is used in your body to build things. You need some, and probably at least half of the number this doc is trying to say is scary. In fact in a different test he is advised to talk to his doctor about whether a 29 is safe. Has the guidance changed that you want LDL less than…

Every organ in your body that utilizes LDL can synthesize it de novo. Some of the heaviest users, like your brain, literally can't get it from your serum LDL levels - they do not pass the blood brain barrier. It is all synthesized locally. PKCS9 inhibitors and mendelian randomization studies show that people function just fine with Googling for statin and aggression links I find a fairly small set of studies with fai…

I believe there was a time they thought statins were causing mood disturbances, but I was talking about unmedicated individuals with naturally low serum levels.

Re: Ticker: Don't die of heart disease

#459

Earlier quoted context omitted.

I believe statins reduce risk by about 30%, so there's a roughly 30% chance the statins have done good things for your dad. (I think that's what the stats mean, right? I'm open to correction on this. I do believe the statin studies, I'm not a science denier. I think what I've said matches the science, as far as I understand.)

The risk reduction is relative risk not absolute

You're right. The absolute risk reduction would be more appropriate here.

Re: Ticker: Don't die of heart disease

#460

Earlier quoted context omitted.

There is a financial incentive not to look.

Whose incentive? All the major drugs are generic now and (at least my) insurance pays for them without even asking for a co-pay.

That's fair. I know a lot of generic drugs are imported too, so maybe there isn't much pressure within the USA there. Unless the big domestic pharmaceutical companies are still making a lot of money on it even if generic options exist? I don't know.
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