Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

GLP-1 drugs: An economic disruptor? (2024)

wildfirelabs.substack.com

Post reply on HN
Print view View original

451–460 of 553 posts

Re: GLP-1 drugs: An economic disruptor? (2024)

#451

Post by petesergeant »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month

... what? Get a better medical provider, you can stay on 2.5mg as long as it's effective. Your hunger will come back. Going up every month is poor practice if you have hunger-suppressing effects, whatever the manufacturer says: speak to an endocrinologist who's experienced with prescribing it instead. The first couple of weeks I had no appetite, but I stayed on 2.5mg for three months and had a healthy appetite by the end, and continued to take it slow. Lost about 1kg a week, and enjoyed my food just fine.

Respectfully, you're in week 3, I think it's worth giving it a few months before you start sharing your experiences of it on the internet.

The much more common experience of this drug -- when you've been on it a little while and you've found a good dosage -- is you enjoy food, you have an appetite, you're just not ALWAYS thinking about food. There is enough anecdata in the many subreddits to constitute actual data about what a typical experience taking any of these things feels like.

Re: GLP-1 drugs: An economic disruptor? (2024)

#452

Post by petesergeant »

Henchman21 wrote: post #291
no_wizard wrote: post #276

Earlier quoted context omitted.

I’m not going to lie all this sounds like heaven to me. I absolutely hate the way my appetite works. I have a genuine dysfunction with food. It goes back as far as I can remember. My cravings never stop, even after being satiated. It’s an endless cycle of weight gain then loss then gain as my willpower fluctuates for a variety of reasons. My insurance only recently started to cover these weight loss drugs, and I have…

I'm a few months into this drug as well, and I have to say, it doesn't offer control . What it offers is a lack of cravings & appetite . That is different, remarkably so. Control would mean I might still feel hungry. Ever. Or that I could decide to eat heavily at one meal, but I don't and as long as I take the drugs, I won't. That doesn't feel like control, it feels like I've had something removed. I guess it's a mat…

Stop moving up the dosage so fast.

Re: GLP-1 drugs: An economic disruptor? (2024)

#453

Post by codingrightnow »

no_wizard wrote: post #276
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I’m not going to lie all this sounds like heaven to me. I absolutely hate the way my appetite works. I have a genuine dysfunction with food. It goes back as far as I can remember. My cravings never stop, even after being satiated. It’s an endless cycle of weight gain then loss then gain as my willpower fluctuates for a variety of reasons. My insurance only recently started to cover these weight loss drugs, and I have…

I'm a major snacker in my 40s, have been most of my adult life. When I don't have my daughter I would fill myself up with cookies, cereal, and chocolate candy. I've been a few months off of all of that shit, accidentally didn't really plan it, I just haven't had any cravings whatsoever. I'm sure it could come back easily but it's not here and I don't miss it. I've lost a lot of fat. I'm not just eating fruit and vegetables, but I'm finding meals alone are enough.

Re: GLP-1 drugs: An economic disruptor? (2024)

#454

Post by aussieguy1234 »

bobsmooth wrote: post #420
aussieguy1234 wrote: post #292

For years, I had the opposite problem most have with their weight. My main problem was gaining it. Food was not enough - I will loose weight relying on food alone. It seems that with food, I often don't like the taste or texture, or the sensation associated with eating. I also tend to feel full relatively quickly. My solution was to make a shake - in this shake, I put a large amount of olive oil, mixed in with other…

Genuine question, what were trips to the bathroom like drinking your olive oil shake?

No issues at all. It could be up to 1/4 olive oil and no problems. There are some cultures in the Mediterranean that also consume alot of it.

Re: GLP-1 drugs: An economic disruptor? (2024)

#455

Post by olddog2 »

IG_Semmelweiss wrote: post #384
derkster wrote: post #318

Earlier quoted context omitted.

Putting Ozempic over the counter at a local pharmacy would be more than enough to keep people from wasting away, the same thing they do with asthma medication. In 2025, if you really want something, a dark web tutorial is 30 seconds away. And from what I've heard from a client, Ozempic on the dark web is roughly 5x cheaper.

sure thing, but can you trust it ? There are so many horror stories abroad (like LATAM), that despite the 4x price point, people still buy US-manufactured GLPs instead of going to a foreign market to get the same prescription. This is being injected directly into your flesh, there cannot be any mistake, or shortcut.

What horror stories?

Re: GLP-1 drugs: An economic disruptor? (2024)

#456

Post by vjk800 »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

It's weird that I've never been overweight and you describe basically how I normally feel.

I've never felt hungry in the morning. I've never eaten a lot. When I was younger, I often forced myself to eat more, because I felt bad about how I wasn't "big enough" (which feels silly now as a proper adult).

Impulse buying food and snacking is something I only do if I haven't eaten for a long time, i.e. if I'm actually very hungry.

If I go out drinking, I also make a point not to eat very much before or during the drinking, because otherwise I just feel sick after like one beer.

Re: GLP-1 drugs: An economic disruptor? (2024)

#457

Post by wincy »

mlboss wrote: post #383
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

What are the side effects ? I heard these drugs just freezes the intestine.

Depends. I tried Ozempic and felt fine but every time I bumped up the dose I’d feel a vague feeling of dread, until I got to the max dosage then I didn’t lose any weight but also felt like I was going to die at any moment. It was bad. I discontinued usage then immediately went back to 300 pounds from 260.

Zepbound/Mounjaro on the other hand has been fantastic. I just noticed I was hurting my muscles a lot and realized it was because I was losing muscle mass. I started taking protein shakes and that seems to have fixed it. Wish I’d realize it sooner as I’ve hurt my hip joint and can’t ride my bike which was primarily how I was exercising, so I need to go to physical therapy. I’m on 10mg and frozen at 260, have an appointment to go to the next dosage on Monday. Hopeful I’ll keep losing weight and get down to around 200.

Re: GLP-1 drugs: An economic disruptor? (2024)

#458

Post by crossroadsguy »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

Two years ago I was some 7-8kg beyond my target weight range. I started calorie cutting, and filling myself with salads etc before each meal. Also added some more changes like taking longer times to eat. I used to, and sadly back to it, eat in a flash. Initially it was hard so increased a bit and then a bit and then in a few days it was stabilised at a calorie intake point which was still significantly below my normal need. And in next few days it dropped further. So next 3-4 months when I was watching calories and trying to keep in check - I didn't have to worry about eating less calories, but I had to worry about taking sufficient calories. Because surprisingly I stopped feeling hungary even eating lesser calories.

I am talking about being okay in 900-1000 while my normal need was ~2500 and nutritionist had suggested to target around 2000 for first few weeks then bring it down to 15-1600 and then slowly bring it up near normal as weight settled. But by the end of 2nd week or 3rd I was struggling to finish 900-1000. I used to kinda force eat.

There was no medication involved in any way (not for this purpose; not for anything else).

Re: GLP-1 drugs: An economic disruptor? (2024)

#459

Post by Clubber »

justinator wrote: post #305
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> The most important aspect of the drug that makes it work so well is it forces you to change your habits, no will power required. It also punishes you for bad eating habits. (That late night trip to McDonalds will have you feeling like shit the next day). But the late night trip to McD's always makes you feel like shit the next day, it's just that we then forget and do it again. (Same with drinking).

The best description of drinking I've heard is, "you're stealing joy from tomorrow for today."

Re: GLP-1 drugs: An economic disruptor? (2024)

#460

Post by qnleigh »

raphman wrote: post #253

Is this person an expert of any kind? They throw around dozens of numbers without any sources. For example, > 'A movie theater chain recently analyzed their user data and discovered that 72% of their profits came from concessions, primarily from impulse purchases made by people who swore they "wouldn't buy anything."' This combination of non-descript source, precise numbers, and 'quotes' looks like the usual bullshit…

This article also throws out a bunch of trends and then attributes them to Ozempic with no evidence.

> America's largest mall operator, Simon Property Group, is converting anchor stores into medical centers and wellness spaces.

Maybe that's because malls have been struggling for years and are trying new tactics in response to that?

> Whole Foods is shifting from endcap promotions to subscription services.

So many industries are shifting to subscription services, because it's so lucrative. What evidence do we have that this is triggered by Ozempic patients??

When will I get downvote privileges on this site...

Post reply on HN