441–450 of 868 posts
This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.
They address this and state that there is no reason to believe it wouldn’t also apply to the general population who do not have lipohypertrophy
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> There's anecdotes, and there's science. > If your solution to the obesity crisis is "people need to try harder" your solution is demonstrably not helpful. Can it work for one person? Yes. Over a population, will it? No Are you an individual or a population though? Take off the telescopes (and data, and science), and look at the world through your own eyes. No one needs (or can) to address the obesity crisis in the…
And odds are very firmly that you'll fail. That's what the science shows us.
I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
I think Ozempic is just a symbol of what modern life looks like. Obesity is a problem that 100% could be solved with a cultural shift (see Japan), but instead we decide to use medicine. It's like, humanity at large grew such big brains because there was evolutionary pressure to be intelligent, but now we're using intelligence to remove that pressure. Which would make sense if we redirected that intelligence to someth…
And those in politics are not interested in change since because (the cynical part starts here) they are selected / sponsored by billionaires who own the media, or go to politics as a job and not to help anyone but themselves
On a side note storing fat to feed the brain in case of bad times makes sense. In the past there were no convinience stores, nor refridgerators
I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
I know why people hate Ozempic. It is because it devaluates struggle and voids moral superiority of those who did keep themselves from becoming obese by self-restriction before: now these people feel like fools because all of a sudden, everyone is becoming slim, and the advantage of being slim disappears. They naturally question how is it fair. Well, life's not fair.
I hate ozempic because I have no reason to be prescribed it and if it has these anti aging effects or improves self control with other vices, I'm missing out and the ex-fatties will all live longer than me
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none of the things you cited are “miracle weight loss drugs.” they are things people did to lose weight. these are the first class of drugs that actually cause people to lose weight.
I would have to check my sources but I'm pretty sure some of them have been prescribed for weight loss at various times. DNP and stimulants I'm more confident of, nicotine and tape worms I'm a bit iffy about.
Amphetamine and methyphenidate(MPH) have very different ways of acting as stimulants. MPH is an inhibitor of the dopamine transporter(DAT) and the norepinehrine transporter(NET). These cross-membrane proteins essentially "suck up" the dopamine or norepinehrine after neurotransmission, thus regulating the effect. MPH inhibits this process, increasing the effect. This is called a norepinephrine/dopamine reuptake inhibitor(NDRI). Cocaine also works like this, as well as the antidepressant wellbutrin(bupropion).
Amphetamine on the other hand, is a bit more complicated. It interacts with DAT/NET as well, as a substrate, actually passing through them into the neuron. Inside the neuron, it has a complex series of interactions with TAAR1, VMAT2, and ion concentrations, causing signaling cascades that lead to DAT reversal. Essentially, enzymes are activated that modify DAT in such a way that it pumps dopamine out of the neuron instead of sucking it up. How that happens is very complicated and beyond the scope of this comment, but amphetamine's activity at TAAR1 is an important contributor. As such, amphetamine is a norepinephrine-dopamine releasing agent(NDRA). Methamphetamine, MDMA, and cathinone(from khat) also work like this.
Anyway, recently I was reading about TAAR1 and learned something new, namely that TAAR1, besides being and internal receptor in monoaminergic neurons, is also expressed in the pancreas, the duodenum, the stomach, and intestines and in these tissues, TAAR1 activation will increase release of GLP-1, PYY, and insulin, as well as slow gastric emptying.
So in essence, there may be some pharmacological overlap between ozempic and amphetamine(I'm still looking for data on how significantly amphetamine reaches TAAR1 in these tissues, so unclear what the relevance is. But amohetamine is known to diffuse across cellular membranes, so it's likely there is an effect).
Also interesting, amphetamine was recently approved as a treatment for binge eating disorder. Not only because it causes weight loss, but because it improves functioning in the prefrontal cortex(crucial to its efficacy in ADHD), which is apparently implicated in the neuropsychological aspects of BED as well.
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Heroine would also help them lose weight also. Maybe cocaine too, but I'm not sure. So it's not "all that matters". What matters is, are the negative side effects and long term consequences better for you than the alternatives. One of them is "remaining fat". The other is "doing what other people have proven works.. cut all carbs".
You are showing your own ass with this ridiculous analogy. What are the negative effects of ozempic? Because the negative effects of heroin (not "heroine") and cocaine are well known and grossly outweigh "not being fat." Is ozempic worse than being fat?
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I think Ozempic is just a symbol of what modern life looks like. Obesity is a problem that 100% could be solved with a cultural shift (see Japan), but instead we decide to use medicine. It's like, humanity at large grew such big brains because there was evolutionary pressure to be intelligent, but now we're using intelligence to remove that pressure. Which would make sense if we redirected that intelligence to someth…
Sure, a lot of problems could be solved with a cultural shift, but most people are in a rat race to survive And those in politics are not interested in change since because (the cynical part starts here) they are selected / sponsored by billionaires who own the media, or go to politics as a job and not to help anyone but themselves On a side note storing fat to feed the brain in case of bad times makes sense. In the…
It's not about "big media", it's about the fact that average voter is an idiot. This a fundamental flaw of democracy.
I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
I know people who used anti depressants for a few weeks, while going to therapy and fixing their shit, they were out of trouble in less than 6 months. But I also know people who've been basically been taking pills for their entire adult life with absolutely no sign of getting better, the pills just make them cope slightly with their shitty routine/job/&c. while completely destroying their body and making them numb to everything. Same for ozempic, I know people who think you just swallow the pill and that's it, they still have horrendous diets, drink 800cal stabucks "coffee", snacks on sweets all day long, and they're actually gaining weight...
Another good example would be sleeping pills, take them once a year to fix your jetlag and they're amazing. Take them for 10 years because you can't fix your routineof watching tv shows in bed until 1am and "need" pills to fall asleep quickly, you'll just fuck up your circadian rhythm for good and it'll be 10 times harder to get out of the cycle
If you truly want to fix your shit virtually any tool is good, but if you just want a magic pill without putting any work you're doomed, the main issue is that it's advertised and sold as a magic pill
Doesn't biological age normally go down with weight loss? Is it just a corollary of the off-label effects of the drug?
It's not that it's going down, the article suggests that it slows. If I lose 20 kilo's, my "biological age" might go down 2 years, but that doesn't mean it's "slowed"
Although one of the clocks they used, DunedinPACE, only looks at pace of ageing, so in that case you can only infer that it slowed (as you do not get an 'epigenetic age' figure from DunedinPACE).