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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#441

Post by loeg »

crazygringo wrote: post #225
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I'm curious -- do you have any brain fog? Are you able to exercise? When you exercise, do you wind up eating more, i.e. the caloric amount that you exercised? I've never had any psychological difficulty with losing weight. I don't care if I'm hungry. But what happens when I eat less and lose weight is that I have trouble concentrating. The glucose my brain needs just isn't there. And if I do physical activity, forget…

No brain fog, but in my experience it does impact exercise (similar to any other caloric deficit). Both maximal efforts (e.g., heavy barbell squats) and endurance (hours on the bike).

Re: GLP-1 drugs: An economic disruptor? (2024)

#442

Post by diebeforei485 »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I think the appetite reduction is too effective for you because you didn't previously have an overeating problem.

For those who do, it makes them have a normal appetite.

Additionally, it seems to make junk food taste less appealing and real food more appealing.

Re: GLP-1 drugs: An economic disruptor? (2024)

#444

Post by wakawaka28 »

the_sleaze_ wrote: post #398
wakawaka28 wrote: post #380

Earlier quoted context omitted.

[flagged]

> blindness, osteoporosis, depression, digestive and metabolic issues I believe each of those are listed in the link he provided. It's up to the individual to make their own decisions as to their own health. At least the information exists with which to make informed decisions.

You're technically right but when people like this keep insisting it's safe in spite of clear evidence to the contrary, and they point to catch-all disclaimers that bury the lead, you might understand how someone would overestimate the safety of the drug.

Re: GLP-1 drugs: An economic disruptor? (2024)

#445

Post by loeg »

crazygringo wrote: post #250
op00to wrote: post #238

Earlier quoted context omitted.

No brain fog. I walk at a very brisk pace ~6 miles a day. My calories are far less than before I started. I have to be very careful to have enough protein. When I exert myself, the recovery period is the same time as before.

Do you have any idea of how many calories you eat per day? I get so confused because the small amounts of food that people talk about eating on GLP, don't seem like enough to sustain themselves long-term. Are they exaggerating? Or do they talk about not eating dinner, but that's because they had 1,700 calorie lunch at the burger place? Or is that just during weight loss, and then once a target weight is hit, they're…

> Do you have any idea of how many calories you eat per day?

My baseline was in the ballpark of 3000-4000 cal/day. I'm losing about 5 lb/month, or 1.25 lb/week; assuming it's all fat, that's a 4400 cal/week deficit or ~625/day. 600 cal a day less is kind of a lot! Some people starting fatter than I was take bigger doses and have bigger deficits.

> Are they exaggerating?

In my experience: I'm not hungry for breakfast at all. Lunch: I try to have it, definitely have it if I exercised. (But if I didn't exercise it's pretty easy to just ignore hunger signals and eat my first meal at dinner.) Dinner is like, smaller than it was when I wasn't on the drugs. And then some post-dinner snacking.

I'm on the low end of the Rx dose range (2.5-15mg/week); on a higher dose, eating even less is plausible.

> Or do they talk about not eating dinner, but that's because they had 1,700 calorie lunch at the burger place?

1700 cal meals are mostly out of the question for me on these drugs. Your gastric emptying is slowed down, so you just can't house big meals in the same way.

> Or is that just during weight loss, and then once a target weight is hit, they're eating like a normal (healthy-weight) person again?

Yes, I think this is a big piece of it. To actually lose weight, you need to eat less than the sustainable steady state.

Re: GLP-1 drugs: An economic disruptor? (2024)

#446

Post by sedgjh23 »

diebeforei485 wrote: post #442
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I think the appetite reduction is too effective for you because you didn't previously have an overeating problem. For those who do, it makes them have a normal appetite. Additionally, it seems to make junk food taste less appealing and real food more appealing.

I was in the overeating column (4000+ calories a day, no sugar drinks) and going into month 3 I am fighting to hit 1500 every day except the day before shot day and shot day. YMMV of course, but it is very effective for me so far.

Re: GLP-1 drugs: An economic disruptor? (2024)

#447

Post by phil21 »

galangalalgol wrote: post #310
op00to wrote: post #243

Earlier quoted context omitted.

It’s actually the opposite. GLP-1s slow down the digestive tract, so my shits are far more well formed than before. This isn’t like olestra, where excess fat caused diarrhea.

Ok I'd been considering it already, but now I'm sold. I have the transit time of a canid.

fwiw tirzepatide (likely the GIP component) cleared up my lifelong IBS within days of my first dose.

I consider it a likely lifelong medication now simply due to that night and day difference to my life. It’s extremely rare I have a day where I need to be within 5 minutes of a restroom now.

My primary care doctor mentioned this might be a side effect when I first started, and she ended up being more correct than even she expected to be.

Re: GLP-1 drugs: An economic disruptor? (2024)

#448

Post by loeg »

crazygringo wrote: post #275
op00to wrote: post #262

Earlier quoted context omitted.

Yes, I calorie track around 1900 calories average. Maybe up to 2000? They are probably losing muscle mass!

Oh, OK. So depending on your height, that sounds fine. So you're still eating plenty, but the point is that you no longer have any desire to over -eat? And so at a restaurant you still order and eat, but the food just doesn't mean "enjoyment" the way it used to? That makes a lot more sense then. If food becomes more about removing a negative feeling of discomfort, than a positive feeling of deliciousness, right then…

Good food still tastes good. You're just less hungry.

Re: GLP-1 drugs: An economic disruptor? (2024)

#449

Post by wakawaka28 »

wakawaka28 wrote: post #270
cedws wrote: post #104

Earlier quoted context omitted.

There are some signs that these drugs have effects beyond just apetite supression leading to weight loss. I recall reading something about them having a direct slowing effect on the metabolism, which increases longevity, among other benefits. I can foresee it being used like a supplement among those who can afford it.

It will probably fuck up your body in ways that we can hardly imagine. Ozempic has been linked to lots of horrible side effects.

(Copied from a post that was flagged) Also, Ozempic suspected of causing:

Osteoporosis: https://www.womenshealthmag.com/health/a62282449/ozempic-bon...

Blindness: https://www.medicalnewstoday.com/articles/review-3-potential...

Stomach paralysis: https://www.webmd.com/obesity/ozempic-and-stomach-paralysis

https://www.nbcnews.com/health/health-news/ozempic-wegovy-li...

Genital infections: https://www.fda.gov/drugs/drug-safety-and-availability/fda-w...

Pancreatitis: https://healthylifebariatrics.com/ozempic-pancreatitis-sympt...

Intestinal paralysis (generally): https://www.healthline.com/health-news/fda-updates-ozempic-l...

Same, leading to colon removal: https://people.com/woman-sues-ozempic-manufacturer-colon-rem...

Depression: https://www.healthline.com/health-news/why-some-people-are-c...

Furthermore, people who say GLP-1 drugs are commonly prescribed omit the fact that diabetics are the main consumers, and their bodies probably work very different from those of normal people.

Re: GLP-1 drugs: An economic disruptor? (2024)

#450

Post by loeg »

j_timberlake wrote: post #303
maleldil wrote: post #289

Earlier quoted context omitted.

> being overweight will be a choice Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

Those side effects are from injecting weekly doses, right? I'm curious if daily oral doses which are smaller will solve a bunch of these problems at once, while also mitigating the supply-chain problems.

FWIW, you can inject half as much twice a week, or whatever schedule works for you. I do it every 3-4 days.
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