Hypothetical scenario - if the entire New Glenn rocket exploded up to highest point in under 4 seconds and if there was a passenger capsule on top with a SLS/Saturn size escape rocket, would it manage to escape in those 2-3 seconds? Would humans survive acceleration?
This has happened before on the Soyuz in 1983[1], hitting up to 17 Gs, and everyone was fine, modulo some bruising.