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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#431

Post by llm_trw »

IncreasePosts wrote: post #350
brokensegue wrote: post #26

Earlier quoted context omitted.

40% of Americans are obese and way more are merely overweight. Either your office is small, a huge fluke, weirdly selected or you're not observant enough.

Well, here in boulder, there are a lot of tech workers, and it is one of the thinnest cities in one of the thinnest states. Having said that, Colorado in 2025 despite being one of the thinnest states is still fatter than the fattest state in 1990.

This is what gets me.

Homer Simpson was meant to be a fat idiot barely hanging on.

In the 40 years since the first episode he's gone to being average weight and fitness.

Economically he's now wildly successful for being able to own a house on a single income with three kids. There are people making over $800,000 today who can't afford that.

Re: GLP-1 drugs: An economic disruptor? (2024)

#432

Post by ph0rque »

_diyar wrote: post #141
dehrmann wrote: post #126

Interesting article, but I do have a nit: > Nike is shifting from "Just Do It" impulse messaging to long-term wellness partnerships My read of "just do it" is actually the opposite. It's a message to dedicated athletes about not making excuses end executing.

In marketing world, many consider the slogan "Just Do It" to have a double meaning: 1) Don't make excuses, get after your goals! (the one you're espousing) 2) Treat yourself, just buy it (the one the articles author is emphasizing).

Just like YOLO can mean You Only Live Once (so make it count).

Re: GLP-1 drugs: An economic disruptor? (2024)

#433

Post by throwaway-1010 »

bcoates wrote: post #381
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I don't have a published study to back this up, but in my 10 Giving a GLP-1 to a heavy drinker/alcoholic results in a skinny alcoholic. Given that the overwhelming majority of alcohol is consumed by heavy+ drinkers this isn't the gamechanger people think it is.

I'm a heavy drinker (1.5 bottles of wine a day -or the equivalent- everyday, for at least 5 years). I started a GLP-1 at 2.5mg two weeks ago after the most recent study was released[1].

In just the two weeks at that low dose it's been quite effective.

In fact the only reason I'm replying to your comment is because instead of being a bottle deep in front of the TV at this point in the evening I got bored after one glass and decided to noddle around on the internets.

Ask any heavy drinker/alcoholic and they will tell you that one doesn't just have 'one' drink and then move on with something else. One is always too much, and never enough. Now it feels like enough.

Happy the share more if you like :)

1. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...

Re: GLP-1 drugs: An economic disruptor? (2024)

#434

Post by dragonwriter »

llm_trw wrote: post #431
IncreasePosts wrote: post #350

Earlier quoted context omitted.

Well, here in boulder, there are a lot of tech workers, and it is one of the thinnest cities in one of the thinnest states. Having said that, Colorado in 2025 despite being one of the thinnest states is still fatter than the fattest state in 1990.

This is what gets me. Homer Simpson was meant to be a fat idiot barely hanging on. In the 40 years since the first episode he's gone to being average weight and fitness. Economically he's now wildly successful for being able to own a house on a single income with three kids. There are people making over $800,000 today who can't afford that.

> There are people making over $800,000 today who can't afford that.

Only because they are spending lavishly on other priorities.

Re: GLP-1 drugs: An economic disruptor? (2024)

#435

Post by cj »

timr wrote: post #145
cj wrote: post #55

Earlier quoted context omitted.

After using them, I think GLP-1’s will eventually be rebranded as a weight management / weight maintenance drug rather than a weight loss drug in order to appeal to the masses. It’s a very interesting feeling to feel like you’re in full control of what you eat, not influenced by random cravings or hunger. In my case I’m planning to only stay on it another month or 2 to drop 10lbs. I can easily see people cycling on/o…

They might be branded that way, but that's not what they are. They have dramatic effects on the metabolic pathway and insulin response that need to be carefully considered if you're not actually diabetic. I recommend that you listen to the most recent Peter Attia podcast, which is a 2+ hour interview with Ralph DeFronzo (diabetes expert) where he goes deep into the effects of GLP-1 agonists on insulin response and ot…

Specific part of the interview that talks about GLP-1 safety with DeFronzo and Attia: https://www.youtube.com/watch?v=QGIFdakceHM

Re: GLP-1 drugs: An economic disruptor? (2024)

#436

Post by llm_trw »

dragonwriter wrote: post #434
llm_trw wrote: post #431

Earlier quoted context omitted.

This is what gets me. Homer Simpson was meant to be a fat idiot barely hanging on. In the 40 years since the first episode he's gone to being average weight and fitness. Economically he's now wildly successful for being able to own a house on a single income with three kids. There are people making over $800,000 today who can't afford that.

> There are people making over $800,000 today who can't afford that. Only because they are spending lavishly on other priorities.

I suggest you look up how much raising children costs today vs the 1980s in both money and time.

Two kids today are a much bigger status symbol than a 5 million dollar house.

Re: GLP-1 drugs: An economic disruptor? (2024)

#437

Post by dragonwriter »

llm_trw wrote: post #436
dragonwriter wrote: post #434

Earlier quoted context omitted.

> There are people making over $800,000 today who can't afford that. Only because they are spending lavishly on other priorities.

I suggest you look up how much raising children costs today vs the 1980s in both money and time. Two kids today are a much bigger status symbol than a 5 million dollar house.

> I suggest you look up how much raising children costs today vs the 1980s in both money and time.

I’m married, living in suburban California raising two of them on a single income much lower than $800,000 (much lower than 2/3 of that, too, since the hypotherical was 3 kids and I don't want that go be a distraction), I don't need to look up anything about a 1980s comparison to know that that $800k claim is sheer insanity.

> Two kids today are a much bigger status symbol than a 5 million dollar house.

No, they aren't. I mean, don't get me wrong I’d rather have my kids than the $5M house, but they definitely are not more of a status symbol than the $5M house would be.

Re: GLP-1 drugs: An economic disruptor? (2024)

#438

Post by op00to »

galangalalgol wrote: post #310
op00to wrote: post #243

Earlier quoted context omitted.

It’s actually the opposite. GLP-1s slow down the digestive tract, so my shits are far more well formed than before. This isn’t like olestra, where excess fat caused diarrhea.

Ok I'd been considering it already, but now I'm sold. I have the transit time of a canid.

It’s wild. I’ve never experienced burping food and tasting what I ate earlier, food just kinda rolls right through. Now, I get to really enjoy it a second time.

Re: GLP-1 drugs: An economic disruptor? (2024)

#439

Post by op00to »

crazygringo wrote: post #275
op00to wrote: post #262

Earlier quoted context omitted.

Yes, I calorie track around 1900 calories average. Maybe up to 2000? They are probably losing muscle mass!

Oh, OK. So depending on your height, that sounds fine. So you're still eating plenty, but the point is that you no longer have any desire to over -eat? And so at a restaurant you still order and eat, but the food just doesn't mean "enjoyment" the way it used to? That makes a lot more sense then. If food becomes more about removing a negative feeling of discomfort, than a positive feeling of deliciousness, right then…

Yeah, I am 6’2 and broad chested etc - I am consistently losing like 2 pounds a week, give or take. If I am less active like due to illness, that slows down. I think any faster than that, and I’d be worried about crashing back to my old weight or other side effects.

I went out to eat today, and enjoyed my food. I didn’t order a big burger, but a smaller sandwich. I had a bite of an appetizer, but not more than a bite. Still super enjoyable, but it might be even better now because I don’t feel like a fat pig afterwards due to reasonable portion size.

I am food motivated like a dog, for whatever that’s worth.

Re: GLP-1 drugs: An economic disruptor? (2024)

#440

Post by aorloff »

no_wizard wrote: post #276
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I’m not going to lie all this sounds like heaven to me. I absolutely hate the way my appetite works. I have a genuine dysfunction with food. It goes back as far as I can remember. My cravings never stop, even after being satiated. It’s an endless cycle of weight gain then loss then gain as my willpower fluctuates for a variety of reasons. My insurance only recently started to cover these weight loss drugs, and I have…

Try reading Gary Taubes and seriously monitoring your carb intake

Your body has 2 separate engines that work completely differently

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