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What happened to the lab-leak hypothesis?

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Re: What happened to the lab-leak hypothesis?

#431

I think this article is a very good example of the sort of pseudo-compelling argument. It's like one step along the road between 4chan conspiracy to Tucker Carlson. It's lots of stuff that sound like reasonable arguments, but are actually not. It starts by couching itself in the actual concensus - other people concluding that's a possibility! - Yes, that's true, but what they're concluding as a possibility out of a c…

Note this also:

>> Imagine if the accidental launch of a nuclear missile had killed 21 million people. It’s hard to believe the world would shrug and say: let’s not bother finding out how it happened.

In other words, somebody did this and we have to find out who it was!

So much about just asking questions, I guess.

Re: What happened to the lab-leak hypothesis?

#432

Earlier quoted context omitted.

Quoted post unavailable.

The rest of the comment is the same exact meritless insinuation I've replied to 100 other times in this thread. It's tiring replying to people who don't understand the first thing about biology or virology because you have to retrace so much ground just to get them to the point where they can comprehend why they're 'not even wrong'. But sure, I'll bite. Aside from the completely false claim there aren't horseshoe bat…

>A small grant ... isn't evidence of a lab leak

The grant is evidence of research not of the leak.

>And the "human subjects" was literally just to run PCRs on people who live near bats to try and catch viruses early.

we don't really know what was done with the "subjects". The IRB document would probably be a good starting point here. When you're doing GoF by specifically increasing human targeting virality by creating chimera viruses in the lab, the "PCRs on people who live near bats" sounds a bit sideway.

> it's not difficult to see whether a virus was engineered or manipulated with GoF research and this one wasn't.

really depends on how GoF is done. So far such conclusions in this case came from the people coopted and prompted by Daszak while those people weren't aware of the conflict of interest that Daszak has here.

>So all of the silly distractions about right-wing bogeyman like Peter Daszak secretly funding Chinese bioweapons are irrelevant.

that is strawman argument. The facts of Daszak involvement is clearly and widely documented. As to his motivation or final target - it is clearly a matter of interpretation and scale of fantasy of the one doing interpretation, and as i already mentioned in Russia for example, where fantasy these days runs amok and political interests are very specifically directed, it is interpreted in the opposite direction - as US building bioweapons. (Note: in my interpretation i see no bioweapons or the likes, just a somewhat dangerous research performed with a bit of corner cutting (not necessary for the reason of costs, as the speed of research at lower BSL also improves a lot), and instead of looking into the mistakes and how to make such research safer - i think such research is unavoidable - the issue got highly politicized with no any useful outcome as a result)

Re: What happened to the lab-leak hypothesis?

#433
post #113

Earlier quoted context omitted.

Sorry but the post above is unscientific sophistry. Science is about weighing competing theories by examining the relative strength of evidence. The evidence is strongly in favor of zoonotic origin. What's posted here is an exercise in confirmation bias, not rigorous scientific thinking.

Given that I used to believe the zoonotic hypothesis the assertion of confirmation bias is a bit surprising to me.

The comment this is a reply to is what's known as rhetoric. The goal of rhetoric is to persuade the audience in the absence of logic or evidence.

The comment is offering "testimony of conversion" which is not scientific.

Re: What happened to the lab-leak hypothesis?

#434

I think understanding the origin is important, but I also understand why it wasn't a media fixation during the pandemic itself. 1) Understanding the origin doesn't change the consequences or response to the pandemic 2) Unlike the nuclear analogy in the article, pandemic virus outbreaks happen naturally, and fairly frequently. Combined with the huge increase in global travel, when one does happen it can be around the…

> 1) Understanding the origin doesn't change the consequences or response to the pandemic I have the opposite opinion. If there was a lab leak and a coverup, this meant that the Chinese government likely knew earlier and had more information about the nature of the virus and how it spread. That could have saved millions of lives. We spent the first several months of the pandemic under the belief that it wasn't airbor…

> If there was a lab leak and a coverup, this meant that the Chinese government likely knew earlier and had more information about the nature of the virus and how it spread.

You're assuming that the lab "designed" it like a new vehicle engine complete with horsepower and torque specs.

Even given it was produced in a lab through chimeras and serial passage then they still wouldn't have known what they had. They wouldn't have known its characteristics in a human population. They wouldn't have known how long its incubation period was, or when peak symptoms and peak transmissibility happened, they wouldn't have known its virulence, or its R0 in a human population or pretty much anything. They'd might have receptor binding assays against the human ACE-2 receptor. That knowledge and $4.25 will buy you a latte, but it won't predict the trajectory of a pandemic.

And why aren't you annoyed at the coverup that China is doing of its zoonotic origins and that China isn't cleaning up all of the trafficking in live animals like palm civets and racoon dogs? We know SARS-CoV-1 happened, and there was no BSL4 lab to blame it on, so it was definitely zoonotic, yet still fairly unexplained, and nothing serious was done to prevent it from happening again. Now the US is blaming the WIV lab and China is feeding its domestic population propaganda about how the US did it, and still nothing is being done to address the mechanism that we know created SARS-CoV-1. There's still a known virological time bomb there that nobody is doing anything about.

And the reason why China wants to cover up the zoonotic origins and kick the can down the road is that it can use the lab leak theory to push the domestic propaganda that the US did, along with avoiding the political costs of clamping down on the animal trade. And there will be a political cost to doing that. Imagine if in 2009 that the H1N1 pandemic happened in a US pig farm and was 100 times worse, and then Obama tried to ban bacon to prevent a future pandemic.

Re: What happened to the lab-leak hypothesis?

#435
post #285

Earlier quoted context omitted.

Sure, but Occam’s is a logical shortcut, not a method of scientific conclusion. I personally suspect a lab leak origin, but I can’t say I have conclusive evidence. I just find it extremely likely based on a myriad of circumstantial evidence, and a lack of any conclusive evidence of natural origin.

I find it extremely unlikely given what I know about biology and how viruses and epidemiology works. Lack of transparency in China is no proof, it's standard operating procedure. They'll try to CYA even if they didn't do anything wrong, maybe especially then. The simplest and most probable way the pandemic started really is the way pandemics usually start: by a pathogen jumping from an animal species to Humans, witho…

Like rzz3, I am suspicious of a lab leak (but reserve judgement). You say the lab leak is unlikely, but do you know better than the WHO? From the article:

> In this we are in line with the US government, the G7, the World Health Organisation and the general public, all of whom are on record as saying that they think a leak from a Wuhan virology lab is a strong possibility that deserves to be investigated. The latest WHO report two weeks ago confirms this, saying that it is important “to evaluate the possibility of the introduction of SARS-CoV-2 into the human population through a laboratory incident”.

China's behavior is suspicious, but as you point out there could be any number of reasons for this. However, that's hardly a basis for exoneration. In either case, China's behavior is surely a confounding factor in understanding what actually happened.

Re: What happened to the lab-leak hypothesis?

#436
post #381

Earlier quoted context omitted.

Thanks- personally, based on my experience in functional genomics, they have far too many assumptions to be trusted as "clocks", even relative ones. Here's the second paper's methods: a molecular clock signal was estimated on the ML tree using TempEst v1.532. BEAST v1.10.433 was used for Bayesian MCMC analysis to estimate temporal nodes. As recommended in Patrono et al., we selected the simplest model: strict clock a…

Their accuracy is completely subject to stable mutation rate and frequency of sample -- with that second paper, they were working with ~10 samples from 15 years ago vs. thousands of samples with hourly granularity and entirely traceable transmission chains in the early days of Covid. Completely different capabilities arise with Covid-level specificity.

Thanks, I'll have to give this some deep thought, it's news to me that having that much more data gives you high resolution in real time.

Re: What happened to the lab-leak hypothesis?

#438
post #113

Earlier quoted context omitted.

Sorry but the post above is unscientific sophistry. Science is about weighing competing theories by examining the relative strength of evidence. The evidence is strongly in favor of zoonotic origin. What's posted here is an exercise in confirmation bias, not rigorous scientific thinking.

Aren’t you assuming that you’re being shown all the evidence?

I'm very clearly and obviously doing the exact opposite

Re: What happened to the lab-leak hypothesis?

#440
post #329

Earlier quoted context omitted.

The prior linked post is a gish-gallop of overconfident motivated reasoning. "Two lineages" in rapid-succession is weird - but no better explained by two zoonoses (that left no hints in any animal population) than two lab-leaks. Worobey et al's analysis is at the mercy of Chinese data sources, and even if all early cases were exclusively in the market, and even the live-animal section, that doesn't disprove lab origi…

> There's a field-wide omerta about gain-of-function risks – who wants to ruin their relationship with the NIH, & admit research that's pretty typical across many leaky labs worldwide, may have killed 20 million people (and counting)? Claims like this, without evidence, reallt detract from any other point you want to make. Because it seems that your thumb is pretty heavy in the scale, without any evidence.

When there are massive institutional incentives to proclaim X, it is only wise to discount, somewhat, proclamations of X.

In Vanity Fair's lab-leak theory story, there was an illustrative detail:

*> Inside the NIH, which funded such research, the P3CO ["Potential Pandemic Pathogen Care and Oversight"] framework was largely met with shrugs and eye rolls, said a longtime agency official: “If you ban gain-of-function research, you ban all of virology.” He added, “Ever since the moratorium, everyone’s gone wink-wink and just done gain-of-function research anyway.”

A whole field wants certain research to happen, with minimal limits. They don't want to admit, or even let themselves believe, that their peers' accident killed 20 million people. It's a hard pill to swallow!

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