Live data from Hacker News

Ozempic shows anti-aging effects in trial

trial.medpath.com

411–420 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#411
post #298

Earlier quoted context omitted.

Then what should I do :(

Get a GLP-1 under the supervision of a doctor or other licensed medial provider.

As a chronically obese, non-diabetic individual, here in Greece it is impossible to convince a doctor to prescribe anything close to that :(

Re: Ozempic shows anti-aging effects in trial

#412

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Some studies have shown people just drop back to their old habits when they stop, and that long-term use isn't good (pancreas, kidneys, etc). It's life changing for some, but like any medication, it shouldn't be used casually.

Re: Ozempic shows anti-aging effects in trial

#413

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of Ozempic. Once he saw what stopping the cravings for certain foods can do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird bionic arm implant.

Lol, a glucose monitor is a bionic arm implant (for $200 total), and an injection disrupting your entire hormone system is what then?

A ridiculous claim.

Re: Ozempic shows anti-aging effects in trial

#415
post #372

Earlier quoted context omitted.

I would have to check my sources but I'm pretty sure some of them have been prescribed for weight loss at various times. DNP and stimulants I'm more confident of, nicotine and tape worms I'm a bit iffy about.

The American Tobacco Company marketed cigarettes for women's weight control in the 1920's. Lucky Strikes 'Reach for a Lucky" campaign was a big example of this as well, although they marketed it as an appetite suppressant rather than simply a miracle weight loss cure.

Keeping in theme, Ozempic specifically has already been marketed off label as an appetite suppressant, rather than a pure weight loss drug. That's a more modern construct in its brief history.

Re: Ozempic shows anti-aging effects in trial

#416

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Just about every single adult woman in my wife's extended family is on Ozempic. None of them are obese at all. Or diabetic. They are all using it to "lose a few pounds" (we're talking like less than 20 pounds; Yes, as you might expect, there are some unrealistic beauty/success standards in my wife's family). So I think there are a lot of people who are annoyed by that, because of the message it sends to completely he…

To be fair, if you're an average height american woman (5'4"), the nominally healthy BMI range is just 37 pounds wide from 108 to 145 pounds, so 20 pounds can be pretty significant.

Re: Ozempic shows anti-aging effects in trial

#417

Earlier quoted context omitted.

Just scale that solution to millions of people and the comparison will be relevant.

If you told millions of people that bread, sugar, pasta and bread are basically killing them, and to flat out stop eating them.. you probably would help people lose weight (and save many lives too). My dad has finally understood that grains are for people that need help maintain weight or gaining weight. No fat person should ever be eating them.

But millions of people are being told; "cutting carbs helps with losing weight" is, I dare to argue, commonly known.

> No fat person should ever be eating them.

This is absolutism and controlling. Carbs have their place in a balanced diet, but key emphasis on diet. Too much (like the US diet) isn't good, none at all isn't good either. Everything in moderation. I don't understand why dieting / weight loss conversations are always going into extremes and absolutes.

Re: Ozempic shows anti-aging effects in trial

#418

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Part of it probably stems from how fast they went mainstream, especially with the weight loss hype

Re: Ozempic shows anti-aging effects in trial

#419
post #299

Earlier quoted context omitted.

I see a similar hesitancy around anti-alcohol addition treatments like naltrexone. People almost _want_ it to be difficult to quit (or lose weight), like there should be some moral struggle associated with it

Its the same root cause: they think alcoholism or alcohol dependency is a moral failing so there should be struggle and punishment to overcome it.

Alcoholism is a moral failing, and the struggle and punishment are real, and come not only from outside, but also from within.

One can try to rationally argue their way out of alcoholism being a moral failing, but then one notices that in a similar way they can “whitewash” any other moral failing, and the words lose their meaning completely.

Yet people use these words to mean something, and abuse of alcohol falls under that meaning, and every society in existence has always cautioned against and condemned it.

Re: Ozempic shows anti-aging effects in trial

#420
post #54

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

There's still plenty to learn about long-term effects, but it's hard to ignore the sheer volume of real-world stories from people saying it gave them their lives back
Post reply on HN