411–420 of 640 posts
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How much does it cost right now? Are there any alternatives coming out soon or generics?
For semaglutide, the newest and most potent GLP1. United States: The main patent is expected to expire around 2032. Monthly Price: $950 - $1,350+ (cash price without insurance) Norway: The main patent is expected to expire around 2031. Monthly Price: $109 - $301 (cash price equivalent in USD)
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> I don't think GLP-1s are particularly expensive On-patent GLP-1s (all of them right now) are actually extremely expensive. Right around $1000 per month. I don’t want to discourage anyone who needs them from seeking treatment, but their discontinuation rate can be somewhat higher than you’d think from a life-changing drug because many people don’t like certain effects or even encounter side effects. Weight loss drug…
I pay about $40/month for mine, grey market from china
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No. Many people have family/kids and want to care for them, and their plan A is to work until retirement. If they die prior to that, the family/kids would be in dire straits. That's plan B, the issue life insurance solves perfectly well. That, in fact, is the general (and beneficial) function of insurance: You only need to provision for the expected loss (plus some fee for the insurance), not the maximum loss (which…
What do you mean by 'expected' loss? You don't mean the expected value in the statistical sense?
Suppose you want to insure your home against fire, which could create damage of say $1m with probability 0.1%.
Without insurance, you'd have to put aside savings of $1m (the maximum loss), that would remain untouched with 99.9% probability, and be used to cover the fire damage otherwise.
With insurance, you'd pay the insurer $1m * 0.1% = $1000, plus a bit on top to cover their cost and profit. In case of fire, they cover your loss. Everyone wins.
So, with insurance you replace provisioning for the maximum loss by provisioning for the expected loss plus a fee.
(That's why one should not get insurance for small items (where one can cover the max), such as baggage or mobile phones or so, but for large items, such as house, life, health).
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If these things really boost life expectancy that much, this sounds like a textbook case for eminent domain.
I'm no fan of the patent system, but "patent system promises spoils for coming up with great new drug, companies comes up with great new drug, companies gets spoils" is exactly how it's supposed to work. Yes, it's sucks that you have to pay, but that's how you incentives getting the wonder drugs invented in the first place. (I have my own take on this, but if anything this is a 'textbook case' in favour of the patent…
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In the 10 or so people I know who are on it, nearly all actually seem to enjoy it - reduced addictive tendencies/bad habits, appetite control, and reduced allergies seem to pretty well outweigh the minor side effects.
I’m INVESTING more. I’ve paid off like $15,000 in debts this year. I swear it’s because of the Zepbound.
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There's often side effects, including nausea, diarrhea, headaches, bloating, discomfort, etc. As far as I can tell from forums, it's not like 5% have the side effects, it's like 80-90%. But for the first time in decades, I felt full. I didn't want to finish a meal, it was too much. My body regulated my food intake in what felt like a natural way. I hadn't even realized my body had somehow lost that fundamental mechan…
From the people I know on trizepitide, side effects were strongest when upping the dosage in the protocol, particularly two days after. The advice I have received while considering it: - change your diet. you can't eat the same food at the same volume. or even is smaller volume if the food is a burger, etc. - watch your drinking, your tolerance for alcohol is reset, and again on the volume thing - drink a lot of wate…
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Just in terms of bad side effects. Hunger was still suppressed. (Might be worse on the higher doses, I'm not on a very high dose.)
Why would that be a 'bad' side effect? Isn't that the whole point of the medication?
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I'm not on any medications, and I've never been able to handle tea in the morning. Green, black, iced, hot, matcha. It always makes me feel nauseated unless I've eaten breakfast first. I always drink black coffee though, without problems.
I am similar. Green tea always makes me feel nauseous on an empty stomach. Tea with milk is normally ok.
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They aren't even that awful in maintenance -- just expensive. The unpleasant part is when you're increasing the dose. After a while at the same dose, it's more or less unnoticeable IMO.
Unnoticable meaning doesn't have any effect at all, or just no bad side effects?
Like if your stomach really hated taco bell and you start taking a pill and now you get the same effect from artificial sweeteners you don't care because you're still within what's normal.
That's the level of side effects these things have.
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Actually yes. Not as much as with ADHD medication, but obvious subset of addictive personalities that have relief from addictive behaviors (beyond eating addiction) with semiglutide.
Appropriately enough, (most) ADHD medications also tend to suppress appetites. So much so that weight loss is perhaps the most serious side effect for ADHD meds in children.