Earlier quoted context omitted.
if you're switching 48v, you'd want a mosfet rated for way more than 50v. On a car you'd want 200% headroom at least.
With totally uncontrolled bus capacitance and inductance, sure. But when you're using the same bus for Comms you need to have control of high frequency spikes, and low frequency spikes are easily handled by a bidirectional DC/DC. Therefore I could imagine peak to peak ripple on this bus to never exceed 1 volt.
https://www.quanterion.com/wp-content/uploads/2014/09/MIL-HD... disagrees.