I hope the game itself is good. I enjoyed 3 and New Vegas, and I'll probably pick this up on or near launch. The thing that's bothered me with Bethesda Softwork's games is that they are stubbornly single thread CPU bound, and don't scale beyond 2 cores that well. Perhaps the newer consoles will force them to multithread better.
Why do you care whether the game uses more than one core. You'd need a truly ancient CPU for the game to demand more compute than a single core provides.
I expect that using a better GPU will improve framerates. There's not much improvement that can be had with a CPU bound game when you're using a high end CPU to begin with. Next year's GPUs will be much faster comparatively to today's, then next year's CPUs.