I wonder how they will stand up against requests from the swiss government regarding lawful intercept access. Which, for larger providers is mandatory to participate in.
In true end-to-end encryption, this would probably not matter, since you can hand over all the encrypted e-mails you want and no one's going to be reading them unless they have your private keys. That said, the nature of in-browser crypto is such that they (or anyone who controls their servers) could intermittently change the JS code they are serving in such a way that it captures your private keys and decrypt all yo…
And even if it would be application based (PGP, S/MIME), it would still leak metadata like crazy.
With all the threat models, I come to the conclusion, that there is no real E2E possible _at_all. All known platforms have been compromised, either by lawful interception/state trojan means or by direct hacking.