I love Qubes; the people involved are awesome. What I'd really like to work on is Compartment Mode Workstation with physically distinct hardware. Essentially, a "windowing KVM" frontend to a bunch of physically separated processor/memory subsystems, connected via well-defined networking interfaces. Essentially X Windows, but actually secure. This is sort of how desktop virtualization (VDI) works today, but with a sep…
It would be reasonably affordable.
Upper limits on the number of processes you could run would be dictated by how many modules you plug in, you could make a backplane like model where you daisychain multiple backplanes for more processes.