Reading the comments, I guess I am the only guy who still doesn't believe in responsive design in the first place.
I just haven't seen a really good implementation of it from a behavior perspective, regardless of what framework or technique is used under the hood. I mean, stacking a three column desktop layout into a single long column for phones is not desirable to me.
And, when I view a full desktop site on a phone or tablet with higher resolution (which is where devices are going), it is typically very readable with the browser's auto-sizing to fit. In rare cases, there is always zooming when necessary. But, resolutions across devices will soon be such that supporting at most two different resolution ranges would be all that is required, if that.
Even if there are rare cases wherein a specific UI can benefit from desktop space where available, with responsive design you'd be making a conscious decision to build a less desirable experience for mobile and other devices. That would imply a separate site with its own UI, optimized as much as possible for the smaller screens. In this case, why try to do so much with each page? Media queries, extensive markup, etc. are effectively adding big, nasty if statements throughout the code. It is ungainly and hard to maintain, even while delivering a sub-par experience. So, if you really are trying to deliver a remarkably different experience per screen format, then it is better to consider a separate site/page-set, IMO.
I think higher resolutions, better browser capabilities, and other changes will make responsive design a "remember when" in the not-too-distant future. And Web designers/devs will breathe a collective sigh of relief, just as we have all done in the past when various painful and short-lived fads went the way of the dinosaur.
But again, maybe that's just me!