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A Disease Without a Cure Spreads Quietly in the West

nytimes.com

41–50 of 62 posts

Re: A Disease Without a Cure Spreads Quietly in the West

#41
My mom lives in Bakersfield and our family own a ranch in the valley (north of Bakersfield). My mom's neighbor had a bad case last year and she said most people know someone who has/had it.

Out where the ranches are, everything is dusty. Much more so than you see to the west in the Salinas valley or where I live (Paso/San Luis/Santa Maria). They built several prisons there years ago. It's pretty much the only lights you can see at night.

Re: A Disease Without a Cure Spreads Quietly in the West

#42
post #5

Well that article makes you feel horrifyingly hopeless. Somewhat related I've read that people who visit other countries for weeks at a time can also get all kinds of illnesses their immune system isn't familiar with, like Americans visiting Japan for a few weeks can catch all kinds of stomach viruses.

[deleted]

Re: A Disease Without a Cure Spreads Quietly in the West

#43
post #40

Earlier quoted context omitted.

Well Fungal cells walls have ergosterol which we humans don't and that is a particular target site for many anti-fungals. In some cases the fungal treatment is longer than usual eg: Nail infection, because it takes very long for the drug to reach the site. The treatment is around 3 months + In most common opportunist fungal infections a few doses of anti-fungal does cure and treat the infection. Also most Healthy ind…

> In some cases the fungal treatment is longer than usual eg: Nail infection, ... I believe I got that and roughly beat it! It only took a few years! Doing some rough carpentry, I dropped a 2 x 4 on my left big toe. No big pain. But later it appeared that I had cracked the nail. Later the nail began to crumble -- likely a fungus among us! Eventually the nail crumbled its way nearly all the way back to the white part.…

LOL glad you have your toe nail back. The treatment would have been much faster had you taken Oral Anti-Fungal Meds.

I understand your concern but if you read the side effects even Aspirin has a TRUCK LOAD of 'em. But most of the serious side effects are extremely rare.

On a related note people complain about Side effects of Meds all the time (and Rightly so) but continue to live un-healthy lifestyles (smoke, loads of Alcohol, Trans Fat, etc) which is a little Ironic :)

Re: A Disease Without a Cure Spreads Quietly in the West

#44
post #6
post #2

Swell. I write this from the Sacramento area (yeah, "the other valley" - Central, not Silicon) as somebody who was born by Bakersfield. OTOH - doesn't every place have its own local diseases and parasites???

>doesn't every place have its own local diseases and parasites? Exactly. This whole article feels like the sort of ego piece you only get out of places like LA or NYC. Every place on earth has diseases and other medical problems caused by local environmental factors. To give it that a name like "valley fever" is to trivialize the fact that the exact same phenomenon occurs everywhere else in the world too.

They call it "valley fever" in the Valley of the Sun (i.e. Phoenix metro area) as well.

Re: A Disease Without a Cure Spreads Quietly in the West

#45

Earlier quoted context omitted.

There is utterly no epidemiological evidence that eating zest has anything to do with any kind of fungal infection.

Of course, that won't actually stop people from claiming there is.

Have you ever actually heard anyone mention the application of anti-fungals to citrus fruit rinds in the first place? Because I've never even heard of it outside of mycology circles, and there are virtually no Google results despite the fact that the practice is ubiquitous.

Re: A Disease Without a Cure Spreads Quietly in the West

#46
We have recently been dealing with this not even knowing it existed prior. We adopted a flat-coated retriever from Kingman, AZ and he was soon diagnosed with a blown-out knee that required radical surgery. Luckily, my wife did some research and cancelled the morning of the surgery as his behavior was not consistent with a bad knee (lame sometimes, run like crazy others). Almost a year later, still lame off and on, my wife felt odd swelling on his leg bone. A new vet took more x-rays and found large lesions just above his ankle. We are lucky it did not affect his lungs, but it settled in his bones which seems painful. He has been on fluconazole for a couple of months and the masses on his leg are shrinking. He has not limped for a couple of weeks now, but I still have to carry him up and down the stairs because the weak leg could break and it would not heal. Treatment will take at least one year.

Arizona was on the top of our list for our next home. Not anymore.

Re: A Disease Without a Cure Spreads Quietly in the West

#47

Earlier quoted context omitted.

There is utterly no epidemiological evidence that eating zest has anything to do with any kind of fungal infection.

"There is utterly no epidemiological evidence that eating zest has anything to do with any kind of fungal infection." No, but there is plenty of evidence that fungi develop resistance to anti-fungal drugs. If I really liked zest I might keep eating it, but since I actually don't like it in the first place I don't find that I lose anything by leaving it out of recipes and cocktails. I certainly wouldn't say that it's…

Actually unlike antibiotics, there is limited evidence of rrsidtence to antifungals. Amphotericin and fluconazole have been around forever and still useful.

Re: A Disease Without a Cure Spreads Quietly in the West

#48

Earlier quoted context omitted.

Of course, that won't actually stop people from claiming there is.

Have you ever actually heard anyone mention the application of anti-fungals to citrus fruit rinds in the first place? Because I've never even heard of it outside of mycology circles, and there are virtually no Google results despite the fact that the practice is ubiquitous.

How does "There is virtually no evidence that this is even done" translate to "This is a big problem"? At least in my book, lack of evidence doesn't count as evidence.

Re: A Disease Without a Cure Spreads Quietly in the West

#49
post #3

The problem also is that you have people who are constantly getting exposed to anti-fungal medications without their knowledge. E.g. almost all supermarket lemons/limes/oranges are coated in anti-fungal cream before being coated with another thin layer of wax, so when you make zest from them (or order a drink with zest at a bar) then you are probably reducing your body's ability to fight off things like this. So much…

Drinks at a bar would be using unwaxed lemons.

It's possible to buy organic unwaxed lemons, so people who worry about what's put on lemons and sealed in with wax can still enjoy zest.

For this post let's assume that all lemons are sprayed with pesticides and fungicides, and then they're waxed. And that the wax is removed by alcohol, allowing the pesticide and fungicide to come off into the drink.

A slice of lemon in a gin and tonic is going to give you a tiny dose. I'd be interested to see if there's any evidence that the pesticides and fungicides are doing any harm. (Especially in comparison to the alcohol.)

Re: A Disease Without a Cure Spreads Quietly in the West

#50

Earlier quoted context omitted.

Almost all fungal (few exceptions) infections are 100 % curable and treatable in most healthy individuals !! Lethal fungal infections (such as Aspergillous and Mucormycosis - flesh eating fungus) are common in immune-comprimised individuals (Diabetics, HIV+ , Organ Transplant Recipients, etc) and very un-common in healthy individuals.

"Almost all fungal (few exceptions) infections are 100 % curable and treatable in most healthy individuals !!" I mean some of them are curable, but anti-fungals are extremely toxic since human cells and fungi cells are very similar. And unlike with bacteria you can't just use antibiotics, since antibiotics mostly come from fungi to begin with. Also, you're not going to be young and healthy forever. At some point you…

> anti-fungals are extremely toxic since human cells and fungi cells are very similar

Anti-fun gals tend to be toxic, not so much because of cell similarity. Ergosterol biosynthesis is not performed by humans.

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