The voice version of DotT is indeed awesome. My favourite example of voice acting in adventure game that you
don't want to click through. Too many games rely on this "ask 23 inquiring questions picked from a list" in a way that becomes really boring, with swathes of dialogue to get through.
(Even worse, in my opinion, are those that require that you delve into a certain part of the dialogue tree in order to get an item or otherwise open up something in the game, which means you have to go through the entire dialogue tree even some of the questions seem uninteresting and you don't want to go through with it. DotT did have a few of those, if I remember correctly.)
I agree about the retro pixel art. A retro style just to capture the essence of a golden age is, in my opinion, philosophically harmful; it quickly becomes annoying. There are some games that sort of redeem themselves: "Superbrothers: Sword + Sorcery", which uses ultra-low-rez graphics blown up to full size combined with fluid animation, is pretty good, although I wound the glib, self-referential tone of the game to be a bit obnoxious. Then there are Wadjet Eye games (like Gemini Rue and Primordia), which use some kind of SCUMM-like, really retro engine, and graphics that are something like 320x200, again blown up to full size, but without any modern animation wizardry. The games are so good that it works, but you do get the sense that the time of this kind of game is, and should be, over.
While I loved the zany style of DotT, I never liked the exaggerated "French" drawing style of Monkey Island 3 [1]. Monkey Island 4 was just awful, and the new Monkey Island episodes are downright creepy in its empty-eyed-doll animated characters, and the "enhanced" remake again does a kind of Disney-style makeover that doesn't quite fit. (Among other things the animation has gone from wonderfully zany to just plain. Watch how they animate talking people [3], it's hilarious.) (Of course, part of the problem with MI3-4 and later was that they turned Guybrush from a likeable, sort of innocent hero into an annoying, clueless, condescending moron somewhere between Chris O'Donnell and Chris Elliot. I don't know if it was the voice, or the hair, or whatever, probably a combination of them. It didn't work for me. It wasn't Guybrush.)
A more recent game that creates a cozy and charming, yet contemporary and technologically up-to-date style is Machinarium. Crisp high-rez graphics, charming animation, fun story, pretty much perfect in every way. That's the way to go, I think.
[1] http://1.bp.blogspot.com/-O8op_6zSEYQ/UBDrWkuhwiI/AAAAAAAAAG...
[2] http://wiimedia.ign.com/wii/image/article/100/1008507/tales-...
[3] http://www.youtube.com/watch?v=b9eJHotWoDQ
