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FDA approves first in class targeted therapy for metastatic pancreatic cancer

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Re: FDA approves first in class targeted therapy for metastatic pancreatic cancer

#41

Post by botro »

silver_sun wrote: post #25
botro wrote: post #21

My father in law was diagnosed with stage 4 pancreatic cancer that's spread to his lungs about a month ago. This news today raised my wife's hopes immensely and had them immediately doused after hearing the oncologist say that although the drug is approved it will take months before they are able to prescribe it. Father in law started chemo a few weeks ago and his condition deteriorated quickly, he's been at the hosp…

Revolution Medicines has an Expanded access program: https://www.revmed.com/expanded-access-policy/ I would suggest you have your physician submit a Expanded access request immediately, because the same page says that they will close this program after FDA approval as they transition to commercial use, but the timeline for that is unclear.

Thank you for sharing.

Re: FDA approves first in class targeted therapy for metastatic pancreatic cancer

#42

Post by billforsternz »

hentrep wrote: post #39
norbertsboat wrote: post #26

Earlier quoted context omitted.

Seriously? So for example the covid vaccine should have been approved in 1 month based on the crisis response or because mRNA approach is transformative, or if it could be made in the US. I feel so much safer knowing a reckless FDA won't be a problem now.

Comparing the acceleration of FDA approvals for non-contagious terminal diseases like PDAC to development of COVID vaccines is flawed on so many levels. You make it sound as though this was just cooked up in some desert meth lab RV over a weekend, and the FDA just rubber-stamped after a cursory glance at the data. The Phase 1/2 study first exploring daraxonrasib (RMC-6236) was posted on clinicaltrials.gov in May 2022…

Good post but the whole "buy time to see your child graduate, get married or give birth" trope is quite frankly very annoying.

Older people have more going on, and more reasons to live, than whatever the next generations are up to. Even if we have children.

I had curative (hopefully, presumably) kidney cancer surgery 11 years ago. So far I've enjoyed travelling, socializing, working, coding, chess and other hobbies in the extra time I've been granted and I hope for decades more time to enjoy life. I don't have children. never aspired to it.

Sorry for the rant!

Re: FDA approves first in class targeted therapy for metastatic pancreatic cancer

#44

Post by jmcgough »

pfdietz wrote: post #28
epistasis wrote: post #4

Metastatic pancreatic cancer is the first indication for this class of RAS-inhibitor, but it certainly won't be the last, and it seems certain that there will be many many more cancers where this drug gets approved. There are mutations to activate KRAS in a substantial fraction of cancers across many organs, and but it's been such a hard protein to target with a drug that even decades ago I was told it was "undruggab…

One downer about this drug is the absolutely horrific side effects, like "your skin feels like you've been dipped in acid" kind of horrific. Still, pancreatic cancer is just that bad, so maybe that's worthwhile.

It's such a big deal to get a working RAS drug. Pharma companies will be pursuing additional drugs of the same class after this - much easier to be the second than the first. I think over the next few years we may see improvements on this, or better figure out how to use it and manage side effects. Very exciting!

Re: FDA approves first in class targeted therapy for metastatic pancreatic cancer

#45

Post by chilldsgn »

Someone I love dearly passed two weeks ago from this awful cancer. She was on a trial for this drug, but it was ineffective, sadly. I can't stop crying. This is a horrible disease and I am so glad there are developments being made in this to extend people's lives, possibly even save them.

Fuck cancer.

Re: FDA approves first in class targeted therapy for metastatic pancreatic cancer

#46

Post by norbertsboat »

hentrep wrote: post #39
norbertsboat wrote: post #26

Earlier quoted context omitted.

Seriously? So for example the covid vaccine should have been approved in 1 month based on the crisis response or because mRNA approach is transformative, or if it could be made in the US. I feel so much safer knowing a reckless FDA won't be a problem now.

Comparing the acceleration of FDA approvals for non-contagious terminal diseases like PDAC to development of COVID vaccines is flawed on so many levels. You make it sound as though this was just cooked up in some desert meth lab RV over a weekend, and the FDA just rubber-stamped after a cursory glance at the data. The Phase 1/2 study first exploring daraxonrasib (RMC-6236) was posted on clinicaltrials.gov in May 2022…

Read the stuff you link to. The FDA article on their criteria says nothing about it needing to be for terminal cancer (is high cholesterol terminal?) Make anthrax hemroid creme in the US and it meets the criteria of the pilot. You should stop falling for scams like being presented with a first result of a pilot that is an improvement and not reading that the pilot itself was created for the other 4 scam cases.

Re: FDA approves first in class targeted therapy for metastatic pancreatic cancer

#48

Post by MarceliusK »

epistasis wrote: post #4

Metastatic pancreatic cancer is the first indication for this class of RAS-inhibitor, but it certainly won't be the last, and it seems certain that there will be many many more cancers where this drug gets approved. There are mutations to activate KRAS in a substantial fraction of cancers across many organs, and but it's been such a hard protein to target with a drug that even decades ago I was told it was "undruggab…

If molecular glues keep working like this, I wonder how many other "undruggable" targets are really just targets we've been trying to attack in the wrong way

Re: FDA approves first in class targeted therapy for metastatic pancreatic cancer

#49

Post by MarceliusK »

jmcharnes wrote: post #11

My sister was diagnosed with pancreatic cancer in October (48 years old) and died in June from it. I'm glad to see a drug like this developed for people suffering from pancreatic cancer. I don't wish what my sister went through on anyone. Damn if I don't wish it had come a little sooner.

I'm really sorry for your loss. There's not much to say to something like that except that I hope this treatment came too late for fewer people than it did for your sister

Re: FDA approves first in class targeted therapy for metastatic pancreatic cancer

#50

Post by mlyle »

billforsternz wrote: post #42
hentrep wrote: post #39

Earlier quoted context omitted.

Comparing the acceleration of FDA approvals for non-contagious terminal diseases like PDAC to development of COVID vaccines is flawed on so many levels. You make it sound as though this was just cooked up in some desert meth lab RV over a weekend, and the FDA just rubber-stamped after a cursory glance at the data. The Phase 1/2 study first exploring daraxonrasib (RMC-6236) was posted on clinicaltrials.gov in May 2022…

Good post but the whole "buy time to see your child graduate, get married or give birth" trope is quite frankly very annoying. Older people have more going on, and more reasons to live, than whatever the next generations are up to. Even if we have children. I had curative (hopefully, presumably) kidney cancer surgery 11 years ago. So far I've enjoyed travelling, socializing, working, coding, chess and other hobbies i…

I have kids.

I also travel, socialize, work, code, play video games, solve puzzles, etc. Love all that shit.

I'd be sad to "miss" some novels, or to never see the Ocarina remake, etc. Or just the time I spend piddling around with things.

But I think if I was about to die and an advance bought me a few months of moderate quality life, it'd mostly be about seeing my kids cross milestones. I don't imagine I'd spend nearly as much time cranking through those things.

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