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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#41

Post by replwoacause »

meetingthrower wrote: post #20
randycupertino wrote: post #4

Earlier quoted context omitted.

I'm on GLP-1 and it's completely stopped my urge to online shop. I used to browse/shop for fun and out of habit or when I was stressed out or wanted a treat etc. Entirely resolved! I've also lost 40lbs on it.

To the others on this reply, I take 1/4 dose of the "clinical dose" and it has been life changing. I've lost 30 lbs. I've done that in the past, but for me that was harder than ranger school in the army. I LOVE food. Eating out and family dinner were always important to me. I was very worried that I would lose my pleasure in this. I haven't. But now I can just eat 1/2 slice of pie. Or 1 scoop of ice cream, etc etc. I…

I've been on Mounjaro for a couple of years. Unfortunately this effect seems to plateau somewhat and you have to bump your dose. I've changed doses 3 times now, so I'm pretty familiar with how long each increase lasts. It still provides some appetite control, but those initial gains, or the honeymoon phase, definitely tapers. Still, I'm better off being on it versus not and I think it allows me to maintain a healthy weight easier. Plus reap all the other benefits we're learning more about.

Re: What Ozempic does to the gut-brain axis

#42

Post by npunt »

barake wrote: post #39
dirtbagskier wrote: post #2

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO

oh say more?

Re: What Ozempic does to the gut-brain axis

#43

Post by brazukadev »

vidarh wrote: post #29
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

Given that we know that diets and changing habits doesn't have lasting effects, what doesn't sit well with me is to risk my health to avoid taking a drug that helps.

changing habits do have lasting effects, I'm not part of this "we" that doesn't know that.

Re: What Ozempic does to the gut-brain axis

#44

Post by sph »

y-curious wrote: post #6

I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.

Very weird (or funny?) to use statins as an example of a ‘good and effective’ drug.

Re: What Ozempic does to the gut-brain axis

#45

Post by chadd »

diggerboy wrote: post #11
dirtbagskier wrote: post #2

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

Did you have to reach a certain dose for such effects?

the minimum dose of monjaro (2.5mg injection once/week) can often be enough

Re: What Ozempic does to the gut-brain axis

#46

Post by kolinko »

LaurensBER wrote: post #31
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

I've gained and lost 10kg twice in my life. Maintaining the weight loss isn't that hard once you've a rhythm dialed in. In my case I just weight myself daily, track the weight and scale my food consumption with the current trend. If I'm gaining weight I'll skip a meal. It takes a while to figure out what works for you but I can tell you that making small lifestyle changes to maintain your weight is fairly easy compar…

Just because it wasn’t hard for you doesn’t mean it isn’t hard for the others. Grom what you said it seems you just had some bad habits you had to fix and that’s it.

Re: What Ozempic does to the gut-brain axis

#48

Post by kolinko »

3stacks wrote: post #34
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

It’s the food equivalent of declaring bankruptcy. If you don’t fix the behaviours you’ll just end up in debt again.

This assumes underlying behaviours are core reason. Research (tein, adoption) suggests otherwise

Re: What Ozempic does to the gut-brain axis

#49

Post by cjbgkagh »

OptionOfT wrote: post #36

My insurance stopped covering, now I'm looking at $450 for Zepbound / month. Just the weight coming back is making me more depressed...

I get mine on the black market, 50c/mg for semaglutide, $3 per month at my current rate of usage. I’ve been on it for years, I was getting gray market at $12/mg for 3 years before RFK clamped down on that market. It’s exactly the same stuff (for me, no guarantee for others), had it tested in a lab and as the side effect profile is on point. It massively relieved my ME/CFS, back when I started there was no way I could have gotten a prescription let alone insurance to cover it.
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