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Improvement in advanced Alzheimer’s disease following high-dose psilocybin

frontiersin.org

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Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#41

Post by boxed »

40four wrote: post #9

This exact case study came up on a recent Rogan episode with Dean Radin, PhD. While the result is very interesting and perhaps illuminating about the unexpected biological mechanisms, apparently the effects were very short lived. Even more interesting, Dr. Radin discussed one of his companies is working on a new drug that uses the same brain receptors as psilocybin, that has the potential to induce similar effects (w…

What does "the effects were very short lived" mean in this context? If it's hours then it seems useless, but if it's months that is short for us normies that expect to live decades more, but for someone who is 90+ that's a pretty nice percentage that is absolutely acceptable if it just means repeating the treatment.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#42

Post by bogwog »

40four wrote: post #9

This exact case study came up on a recent Rogan episode with Dean Radin, PhD. While the result is very interesting and perhaps illuminating about the unexpected biological mechanisms, apparently the effects were very short lived. Even more interesting, Dr. Radin discussed one of his companies is working on a new drug that uses the same brain receptors as psilocybin, that has the potential to induce similar effects (w…

Unless it's a different Dean Radin, PhD, Wikipedia describes this guy as a psychic: https://en.wikipedia.org/wiki/Dean_Radin

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#43

Post by boxed »

fred_is_fred wrote: post #24
sva_ wrote: post #6

> n=1 > pay to publish journal > no clear Alzheimers diagnosis ("[...] were considered clinically most compatible with advanced Alzheimer’s disease") > administration of a heroic dose of street-quality drugs vs. a controlled sample > no university or hospital affiliation? Extraordinary claims require extraordinary evidence, hence I remain skeptical

Not only that but the author has appeared on Joe Rogan - that tells me all I need to know.

That's a silly statement. There's been plenty of people who went on there to try to talk sense into him.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#44

Post by bogwog »

ekianjo wrote: post #28
sva_ wrote: post #6

> n=1 > pay to publish journal > no clear Alzheimers diagnosis ("[...] were considered clinically most compatible with advanced Alzheimer’s disease") > administration of a heroic dose of street-quality drugs vs. a controlled sample > no university or hospital affiliation? Extraordinary claims require extraordinary evidence, hence I remain skeptical

Good criticism but be aware that acreditated authors and institutions are a bunch of crooks on the whole who cook their results, do p-hacking to the death, badly document their protocols, don't release their datasets not their analysis, and have no problems getting paid by big pharma and not disclosing it fully. The field is more joke than science at this stage.

Yeah, and a cure for cancer exists, but big pharma keeps it in a secret vault because treatments are more profitable than cures /s

I recently lost a family member to cancer, and had to go through this conspiracy bullshit from evil pieces of shit peddling snake oil to desprate people. Whatever rabbit holes your social media algorithms have led you down aren't healthy, friend. Clear your cookies and go touch grass.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#45

Post by tokai »

jszymborski wrote: post #40

So, I'm not making any accusations or decelerations of "bad science", I've only read the abstract and this isn't my field. That said, some relevant context here is that: (1) Case studies are some of the most easily fabricated journal outputs (2) This is published in Frontiers in Neuroscience, which is listed by some as being a predatory journal [0]. The Frontiers publishers are the fine folk who published an AI gener…

I would not trust predatoryjournals.org. Beside the site looking much like the worst predatory journals, they have no transparency in who they are and how they evaluate journals. It seems just to be Beall's old list, with some newer things thrown in.

I'm not saying that Frontiers in Neuroscience is not predatory, but its not a proper argument for it to be predatory, to point to a random list as proof. As Beall couldn't understand being crap publisher is not predatory in it self.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#46

Post by ozgrakkurt »

wouldbecouldbe wrote: post #39
Aurornis wrote: post #26

Earlier quoted context omitted.

Psilocybin is harder to get research approvals for than many things, but it’s not “completely banned”. There are studies every year being completed with psilocybin, many of which get posted here on HN. There is a growing tension between the extraordinary pop culture claims of psilocybin curing everything (now extending to Alzheimer’s due to this 1 low-quality report from Brazil) and the actual studied effects, though…

When you take it, you understand, that if taken with the right approach it can lead to profound insights in changing your life and the effects described: helping with depression, addiction and accepting death are not far fetched at all. Yet it can also, if not guided or done on someone with anxiety have the opposite effect. The more biological effects I agreed are not conclusion that can be drawn from that.

> When you take it, you understand

To be fair, this is not how medical research is done.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#47

Post by repple »

jszymborski wrote: post #40

So, I'm not making any accusations or decelerations of "bad science", I've only read the abstract and this isn't my field. That said, some relevant context here is that: (1) Case studies are some of the most easily fabricated journal outputs (2) This is published in Frontiers in Neuroscience, which is listed by some as being a predatory journal [0]. The Frontiers publishers are the fine folk who published an AI gener…

They do add:

> Generative AI statement

> The author(s) declared that Generative AI was not used in the creation of this manuscript.

> Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.

Which is good.

But it makes me wonder about “wherever possible”. In which case wouldn’t it be possible and why would it remain if it’s not possible?

edits: formatting

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#48

Post by NoMoreNicksLeft »

Aurornis wrote: post #26
trumpdong wrote: post #16

Psilocybin is one of those things we don't even know the full effects of because the government had a hysterical fit and completely banned it because people who took it were more likely to oppose the Vietnam War.

Psilocybin is harder to get research approvals for than many things, but it’s not “completely banned”. There are studies every year being completed with psilocybin, many of which get posted here on HN. There is a growing tension between the extraordinary pop culture claims of psilocybin curing everything (now extending to Alzheimer’s due to this 1 low-quality report from Brazil) and the actual studied effects, though…

>There is a growing tension between the extraordinary pop culture claims of psilocybin curing everything (now extending to

That's the playbook that got marijuana (more or less) legalized. So of course they're going to use the same exact strategy with each drug in turn.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#49

Post by bilsbie »

trumpdong wrote: post #16

Psilocybin is one of those things we don't even know the full effects of because the government had a hysterical fit and completely banned it because people who took it were more likely to oppose the Vietnam War.

What’s exciting though is that this administration recently signed an executive order directing the agency to speed up the development and approval process for psychedelics.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#50

Post by Lucasoato »

bogwog wrote: post #42
40four wrote: post #9

This exact case study came up on a recent Rogan episode with Dean Radin, PhD. While the result is very interesting and perhaps illuminating about the unexpected biological mechanisms, apparently the effects were very short lived. Even more interesting, Dr. Radin discussed one of his companies is working on a new drug that uses the same brain receptors as psilocybin, that has the potential to induce similar effects (w…

Unless it's a different Dean Radin, PhD, Wikipedia describes this guy as a psychic: https://en.wikipedia.org/wiki/Dean_Radin

> Radin's paranormal ideas and work have been widely criticized by skeptic scientists and philosophers.

I'm not sure I'd trust this person for anything related to science.

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