So all I gotta do is eat some poop and it will save me from becoming a handsome, funny, unique genius?
You don't eat it, don't be silly.... you stick the poop up your butt
... Back and forth, forever?
Fecal transplants for autism deliver success in clinical trials (2019)
41–50 of 250 posts
Re: Fecal transplants for autism deliver success in clinical trials (2019)
#42>> In early 2022 Krajmalnik-Brown and colleagues patented a specific bacterial formulation and spun-off a commercial company called Gut-Brain Axis Therapeutics.
I was a little surprised to see this.
So the university researchers use time and money from the university to make a discovery, extending on previous published research, and then patent it and start their own for-profit?
Excuse my ignorance, but is that how it's done generally? Where's the upside for all those who are potentially affected?
It kinda makes sense - Presumably the university is involved somewhere still, and it needs to be commercialised somehow, but..
Re: Fecal transplants for autism deliver success in clinical trials (2019)
#43>> In early 2022 Krajmalnik-Brown and colleagues patented a specific bacterial formulation and spun-off a commercial company called Gut-Brain Axis Therapeutics. I was a little surprised to see this. So the university researchers use time and money from the university to make a discovery, extending on previous published research, and then patent it and start their own for-profit? Excuse my ignorance, but is that how i…
Yes this is really common. Not all universities own the research you do. I have a similar setup within my university. They get to use the research technique I've worked on, but I have the rights to take it out of the university and sell it.
Re: Fecal transplants for autism deliver success in clinical trials (2019)
#44I got bad chronic constipation after four years as a strict carnivore. I didn't get relief just by adding back fiber, but I did by adding fermented foods like kimchi. I wonder if ferments are a more natural way than fecal transplants to repair the gut microbiome, possibly treating autism. Studies have been non conclusive, but this story makes me think it's worth pursuing.
>I got bad chronic constipation after four years as a strict carnivore. 2 questions: 1) Did your constipation start right after you did strict carnivore? Or was it after 4 years? 2) List all foods that you ate on strict carnivore. (Include salt, water etc. I presume it won't be a long list)
Just all foods including salt and water consumed over a 4 year time period with some unknown offset from present, sure seems like a reasonable amount of effort in response to some random guys HN post.
Re: Fecal transplants for autism deliver success in clinical trials (2019)
#45>> In early 2022 Krajmalnik-Brown and colleagues patented a specific bacterial formulation and spun-off a commercial company called Gut-Brain Axis Therapeutics. I was a little surprised to see this. So the university researchers use time and money from the university to make a discovery, extending on previous published research, and then patent it and start their own for-profit? Excuse my ignorance, but is that how i…
Universities often keep up to 50% of rights over IP in such cases but I am unsure about this specific case.
Re: Fecal transplants for autism deliver success in clinical trials (2019)
#46>> In early 2022 Krajmalnik-Brown and colleagues patented a specific bacterial formulation and spun-off a commercial company called Gut-Brain Axis Therapeutics. I was a little surprised to see this. So the university researchers use time and money from the university to make a discovery, extending on previous published research, and then patent it and start their own for-profit? Excuse my ignorance, but is that how i…
Yes, it's really common. Most universities actually support this and there is a specific contractual framework for staff which basically says "If you create a company during or after your work at university which touches the field you were researching in, we get 1% (or 10% or 20%) of your annual revenue as license fees".
The alternatives are lengthy court battles between universities and their best (e.g. most commercial) researchers. This creates bad PR for the university and uncertainty for the researcher & their startups because potential investors don't like open court cases.
So people came around to make this kind of license fee contract and researchers check it before deciding to join a certain university.
Not a fan of gene / bacteria patents though.
Re: Fecal transplants for autism deliver success in clinical trials (2019)
#47Earlier quoted context omitted.
Makes you wonder how hard would it be to just put it in a swallowable capsule that dissolves only in the upper intestine. Also, "fecal transplant" is marketable only to weirdos. "Probiotic infusion" would work better. For those who want to gain some artistic talent, there's this (but is expensive): https://en.wikipedia.org/wiki/Artist's_Shit
From my understanding, the problem is volume. You want to land a substantial amount of, ahem, shit in there, since don't just want it to colonize one portion of the gut, and it's got quite a lot of competition. So you would be talking a truly astonishing number of pills, I think, to compare to the volume you can manage with a tube. WP suggests that it's about 100g (or 100000mg) of actual feces then mixed in a larger…
Good point, but shit seems to be made of a lot of stuff- ~75% water, undigested food and fiber, fats, inorganic matter... Bacteria seem to be about ~30% of the dry weight. So of those 100 grams, you'd get maybe 7/8 grams of bacteria? If so, these could possibly be delivered by a number of small capsules taken in the course of several days.
Re: Fecal transplants for autism deliver success in clinical trials (2019)
#48>> In early 2022 Krajmalnik-Brown and colleagues patented a specific bacterial formulation and spun-off a commercial company called Gut-Brain Axis Therapeutics. I was a little surprised to see this. So the university researchers use time and money from the university to make a discovery, extending on previous published research, and then patent it and start their own for-profit? Excuse my ignorance, but is that how i…
> So the university researchers use time and money from the university
Don’t worry, the money is usually coming from taxpayers so the universities don’t have to dip into their endowments
Re: Fecal transplants for autism deliver success in clinical trials (2019)
#49>> In early 2022 Krajmalnik-Brown and colleagues patented a specific bacterial formulation and spun-off a commercial company called Gut-Brain Axis Therapeutics. I was a little surprised to see this. So the university researchers use time and money from the university to make a discovery, extending on previous published research, and then patent it and start their own for-profit? Excuse my ignorance, but is that how i…
It's quite common historically. The Entrepreneurial State by Mariana Mazzucato looks at this phenomenon of companies privatizing the benefits of publicly funded research and, she argues, not giving enough in return