FTDI (the company practically synonymous with TTL serial adapters) uses 3.5mm tip-ring-sleeve connectors for this. In other words, a common headphone jack. I added one to my single-board computer enclosure, following FTDI's wiring. Now I can easily connect whenever I need to use the serial console, and a standard 3.5mm audio extension cable will let me reach across the room without moving my main computer. Replacemen…
That really sucks for hotplugging since TRS connectors sliding in basically make random connections before seating properly. Granted, you shouldn't hotplug TTL serial, but everyone™ does it anyway. (In some situations you're even forced to, to avoid reverse powering something.)
It works well for capturing serial logs, a console or software updates in development. The advantage i saw was that I could order 50 cables from a distributor and give one to everyone that works on the device.
If someone needs one on the other side of the world, they can get one from a local suppliers.
Hot plugging hasn't been a problem in my designs, I add a series resistors to the uart net and ESD protection if software developers will use it.
When I use it for other devices, like routers, SBCs and IP cameras I avoid hot plugging and leaving it connected when the device isn't powered.