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Nuclear receptor 4A1 linked to health effects of coffee: study

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Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#41

Post by rendaw »

technothrasher wrote: post #14
obsidianbases1 wrote: post #7

Earlier quoted context omitted.

Are you familiar with the process of extracting the caffeine in decaf? Unfortunately it isn't without potential downsides.

Yes, I know the four main methods of decaffeination. The haters have gone down this road with me many times. Why can't people just let me drink my decaf? It's like they can't enjoy their caffeine unless everybody does. It's weirdly pushy.

I don't think GP was criticizing you for liking decaf. Just pointing out that the decaf process may have affects on the beneficial compounds that aren't caffeine.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#42

Post by ragall »

technothrasher wrote: post #14
obsidianbases1 wrote: post #7

Earlier quoted context omitted.

Are you familiar with the process of extracting the caffeine in decaf? Unfortunately it isn't without potential downsides.

Yes, I know the four main methods of decaffeination. The haters have gone down this road with me many times. Why can't people just let me drink my decaf? It's like they can't enjoy their caffeine unless everybody does. It's weirdly pushy.

By "All you haters that give me grief for drinking my daily cup of decaf can shut up now", you are implying that decaf has the same health benefits of real coffee. That's not proven. And if you weren't meaning to imply that, there was no point to that reply.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#44

Post by campbel »

JXavierH wrote: post #36
Bridged7756 wrote: post #27

I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.

That's why I moved to decaf. Love coffee, caffeine doesn't like me.

I am definitely going to do this as I age, I just don't need the stimulant effects as much anymore. That said, the ritual of getting coffee and sipping on something warm in the morning is really important to starting my day right.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#45

Post by raducu »

coffeebeqn wrote: post #23
cf100clunk wrote: post #13

Earlier quoted context omitted.

Are you researching whether you'll get cancer if you are extracting 100% pure nicotine and ingesting it? Who does that?

Most nicotine users today? Everyone’s using the pure nicotine pouches like zyn and such. I didn’t really find it enjoyable at all

> Most nicotine users today?

I did use pure nicotine and it was very bad for my health, probably due to high dosage, but still.

I've used heavy stimulants, benzos, opioids, dissociatives without an issue, but nicotine is in a class of its own in terms of how insidiously addictive it is.

But just from a health point of view: extreme arm and hand joint issues, forearm vascular issues that made my hands numb at night, palpitations/arrithmia like I was about to die when I used nicotine before sleep and I was drifting to sleep -- it really felt like I was about to die, like my heart was mangled up.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#46

Post by joe_mamba »

JXavierH wrote: post #36
Bridged7756 wrote: post #27

I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.

That's why I moved to decaf. Love coffee, caffeine doesn't like me.

Sadly, I can't. I tried all the decaf beans in my area and even some fancy online roastery specialized only in decaf beans, and they all tasted like ass, compared to their caffeinated cousins. So much money wasted trying to find good tasting decaf beans.

Not sure what the decaffeination process does, but it definitely does not preserve the taste of the "untouched" beans. Are my tastebuds too sensitive?

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#47

Post by jorvi »

Bridged7756 wrote: post #27

I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.

Unfortunately the most flavorful methods (espresso, french press, moka) also raise your cholesterol. So sadly, no, coffee is not universally "good for you". Filtered coffee methods are though, as the filter absorbs the oils.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#48

Post by panabee »

Here are more fascinating facts about caffeine and cancer.

Caffeine affects the immune system via at least two opposing mechanisms.

Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor.

Mechanism 2: Raising intracellular cAMP (immunosuppressive) Caffeine also inhibits phosphodiesterase, the enzyme that hydrolyzes (i.e., breaks down) cAMP. cAMP accumulates inside immune cells, which acts as a "calm down" signal.

Note: both mechanisms are dose-dependent. At dietary caffeine levels, A2A antagonism likely dominates, whereas PDE inhibition is weak and mainly relevant at higher concentrations. However, the net immune effect in the tumor microenvironment remains unproven.

---

If you would like to learn more, I can outline a framework for technical folks to ease in and become more informed on cancer. Gaps abound. The more people who understand cancer, the faster we get to cures. Moreover, personalized cancer treatment is the obvious future. Knowledge acquired now may pay off later (but hopefully not needed).

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#49

Post by helterskelter »

campbel wrote: post #44
JXavierH wrote: post #36

Earlier quoted context omitted.

That's why I moved to decaf. Love coffee, caffeine doesn't like me.

I am definitely going to do this as I age, I just don't need the stimulant effects as much anymore. That said, the ritual of getting coffee and sipping on something warm in the morning is really important to starting my day right.

[dead]

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#50

Post by ifwinterco »

jorvi wrote: post #47
Bridged7756 wrote: post #27

I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.

Unfortunately the most flavorful methods (espresso, french press, moka) also raise your cholesterol. So sadly, no, coffee is not universally "good for you". Filtered coffee methods are though, as the filter absorbs the oils.

Which is why Italians and Greeks famously all die young of heart disease
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