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Peptides: where to begin?

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Re: Peptides: where to begin?

#41

Post by diath »

kylehotchkiss wrote: post #20

With India getting generic GLP-1s, the tech to "print" peptides will probably see costs fall off a cliff, so we're probably only looking at the tip of the iceberg with the amount of damages the reddit biohacker bros will accomplish. Men especially are feeling a lot more lonely and image-conscious and there are peptides people claim make them taller[1] or muscular[2]. 1: https://www.reddit.com/r/endocrinology/comments…

These peptides are already relatively cheap, here's one US domestic source: https://imgur.com/a/OXOkSdR

Re: Peptides: where to begin?

#42

Post by hellojimbo »

jmye wrote: post #13
Bender wrote: post #3

It seems we are treating Peptides like drugs here. It's my opinion that amino acids regardless of how they are chained do not belong under and stricter regulation than food given I eat peptides every day from my food. Then again I do not believe in the concept of prescription drugs. Everything with a NDC code should be at the grocery store and I should be able to stock up on it without permission especially given how…

> Drugs risks do not enter into the picture given the fact I can buy ammonia and bleach along with a myriad of other dangerous compounds. This is a deeply weird take. You think anyone ought to be able to buy, for instance, warfarin and freely take it without a doctor’s involvement? We should let parents self-diagnose diabetes and administer insulin without a prescription or discussion? We should just hope that patien…

Your argument is even worse lol. Obviously he's proposing that you can take your doctors note to the pharmacy and get what the doctor prescribed in addition to being allowed to self purchase behind the counter drugs.

Re: Peptides: where to begin?

#43

Post by kube-system »

hombre_fatal wrote: post #35
A_D_E_P_T wrote: post #27

Earlier quoted context omitted.

I'll give you a case in point. This article was discussed the other day: > https://www.nytimes.com/2026/04/02/technology/ai-billion-dol... People want GLP-1 drugs. They can't get them without a prescription. They pay $$$ to a "telemedicine" "doctor", recite a list of well-known symptoms, and buy the prescription. The system is that you can't buy these drugs without the piece of paper, and the piece of paper is basica…

I think access is a good thing. The issue isn't with telemedicine but the fact that there's a prescription wall for helpful meds like GLP-1 in a country where we've failed people by creating one of the worst food environments. Also, most doctor's visits aren't any different from getting it if you want it except it's gated on the mood/attitude of the doctor, maybe your ability to sell some sob story. And then you book…

GLP-1 prescriptions are easy to get in the US. It's filling the prescription that is the problem, because insurance rarely covers it and it is beyond the disposable income of most Americans.

The prescription hurdle is absolutely necessary -- these are not drugs that anyone can safely take without guidance. It's the price that needs to be fixed.

Re: Peptides: where to begin?

#44

Post by cheald »

tbojanin wrote: post #21

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…

I used a combo of low-dose retatrutide, tesamorelin, and ipamorelin and lost about 15lb over 45 days, including 60% of my visceral fat, and put on 4lb of muscle, per before-and-after DEXA scans. I lifted regularly, ate well, and prioritized protein, and while I definitely under-ate protein, I was very pleased to find that I was able to increase muscle mass while cutting the fat. My visceral fat was the primary target here, since I'd been unable to get it to budge despite consistent training and diet. Very pleased.

Re: Peptides: where to begin?

#45

Post by twodave »

tbojanin wrote: post #21

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…

Did you work out during those 10 weeks any? TBH if you went from regular lifting to not for 10 weeks I'd expect a similar decrease in your lifting numbers (though not a .4lb/day weight loss of course)

Re: Peptides: where to begin?

#46

Post by hammock »

tbojanin wrote: post #21

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…

Those are sizable drops for 10 weeks unless you stopped lifting as well

Re: Peptides: where to begin?

#47

Post by cheald »

orf wrote: post #17
diath wrote: post #15

> My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a compound studied in 14 humans, from unregulated sources, based on the recommendation of someone who profits from selling it. She’s probably not the only one. And those using it believe they are “doing their own research.” Ok, and? At worst you waste a couple…

You know dozens of people from a single place that have chronic tendon/joint issues?

Hang out at a BJJ or MMA gym for a bit, and you'll find plenty. Peptides are really popular in combat sports circles, with good reason.

Re: Peptides: where to begin?

#48

Post by __MatrixMan__ »

olalonde wrote: post #36

The author is missing a massive segment of that gray market: people who buy FDA-approved weight loss drugs (e.g., semaglutide or tirzepatide) at 2–5% of the brand-name price. This route carries some risk, but there are ways to mitigate it, such as performing third-party testing. I assume most people who do this couldn't realistically afford the brand-name drug anyway, making this their only viable treatment.

I imagine it's legally risky to buy a large quantity, test it, and then resell smaller quantities. That's a shame because the alternative is probably that some folks settle for products of dubious quality and end up getting hurt.

Re: Peptides: where to begin?

#49

Post by GenerWork »

diath wrote: post #41
kylehotchkiss wrote: post #20

With India getting generic GLP-1s, the tech to "print" peptides will probably see costs fall off a cliff, so we're probably only looking at the tip of the iceberg with the amount of damages the reddit biohacker bros will accomplish. Men especially are feeling a lot more lonely and image-conscious and there are peptides people claim make them taller[1] or muscular[2]. 1: https://www.reddit.com/r/endocrinology/comments…

These peptides are already relatively cheap, here's one US domestic source: https://imgur.com/a/OXOkSdR

$120 for 10mg of reta is highway robbery.

Re: Peptides: where to begin?

#50

Post by phil21 »

jmye wrote: post #7
A_D_E_P_T wrote: post #2

Lowe has a point, but the FDA has painted itself into a corner by (a) forcing up the costs and the various bureaucratic demands associated with clinical trials, (b) allowing drug advertising , but then forcing those comical "may cause death" disclaimers, both of which have become totally ubiquitous, and (c) inconsistently following its own rules, and in some cases flouting its own rules. At this point, broscience is…

> Another point I could raise is that telemedicine has turned the entire prescription system into nothing more than a parasitic middleman/gatekeeper. I’m curious what you mean by this. I’m not sure what you mean by “prescription system” specifically.

> I’m curious what you mean by this. I’m not sure what you mean by “prescription system” specifically.

They basically operate as a "pay for a prescription" service.

Figure out what drug you want, google the drug name and telehealth. You will be marketed in a wink wink sort of manner over how easy it is to get them, just hours away! Then if you are not a total idiot, you answer certain questions in the right manner on the intake form, the doctor (usually NP/PA or similar for most things) will quickly run through that and expect you to answer correctly - perhaps guide you a bit if you don't.

5 minutes later you have a prescription in the web portal and it's sent to your pharmacy of choice.

It really shows how the whole "permission slip" program is BS. I've used these services a couple times vs. my normal doctor just to save time and expense of an office visit. If I can click some buttons, have a call 30 minutes later, and be on my way to the pharmacy for $50 it's sometimes the path I take now vs. traditional route.

Someone used to the traditional doctor/patient relationship thing and prescriptions being "holy" would be shocked at how easy and gamed it all is.

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