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Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

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Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#41

Post by jcranmer »

nikkwong wrote: post #30
jcranmer wrote: post #26

Too bad we've had like a half-dozen putative Alzheimer's drugs that clear amyloid beta that turn out to do nothing to slow or prevent Alzheimer's. Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?

That's not true. Monoclonal antibodies are on the market right now which slow the progression of the disease (by removing amyloid).

AIUI, all such results are because the FDA has given up since aduhelm and said "well, if it clears amyloid, that's as good as slowing Alzheimer's, right?" despite the actual results on Alzheimer's progression being largely negative.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#42

Post by farmdawgnation »

mrosett wrote: post #27
Aurornis wrote: post #10

I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…

Reminds me of this classic: https://xkcd.com/1217/

There may not be many constants in this life, especially in this day and age, but I do find it humbling that "there is always an xkcd for that" holds true.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#43

Post by lithocarpus »

throwaway27448 wrote: post #36
jojobas wrote: post #31

Earlier quoted context omitted.

Can't have Alzheimer's if you don't have much of a brain left.

Can you explain the joke?

If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#44

Post by criddell »

laughing_man wrote: post #24

Do we still think clearing beta amyloid plaques will halt the progress of Alzheimer's? My impression is we're treating marker for the disease and not the cause.

Not halt, but slow the progression.

https://www.nebraskamed.com/health/conditions-and-services/n...

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#45

Post by dyauspitr »

rusakov-field wrote: post #7

Man, too bad weed gives me bad panic attacks. Alzheimers is the scariest disease I know so maybe if the studies pan out in time and it becomes a standard preventative, I might consider trying again. But somehow I doubt it will be found to be that effective.

I’ve found the edible thc (gummies/drinks) you get in non-legal states are much less panic/anxiety inducing. I’m not sure why but it probably has to do with CBD or something that is missing. It’s anecdotal but I’ve noticed it a lot. They also get you very high so I’m not sure how exactly they are getting around the legality requirement.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#46

Post by hirvi74 »

_zagj wrote: post #29

And yet, has anyone ever claimed regular marijuana use improved their memory?

Ok fine, I'll chime in.

No, it has not improved my memory. Though, I am not really certain anything does. At least, not permanently. Though, I will say the effects on memory are rather complex. Some diminished abilities in some domains, but oddly some enhancements in a select few domains.

I am 'neurodivergent' apparently, so my experiences might not be worth much.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#47

Post by macNchz »

wafflemaker wrote: post #23
Loughla wrote: post #14

Earlier quoted context omitted.

I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…

Always thought that panic attacks were caused by too low CBD in regards to THC levels. Saw someone literally suggesting keeping a CBD vape pen just in case of a panic attack. Or a friend using it for heart palpitations. Wasn't the amount of THC concentration in resin seen as the indicator of potency? Then that amount was hacked through selective breeding, unbeknownst that not following with a complementary increase i…

In legal states in the US it’s fairly easy to find commercial 1:1 THC:CBD products, among a litany of mega-potent THC-only options.

I never particularly cared for cannabis in general in the past–it didn’t give me panic attacks, but even a little bit made me feel kind of on edge. The 1:1 stuff is dramatically more pleasant.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#49

Post by xeromal »

throwaway27448 wrote: post #36
jojobas wrote: post #31

Earlier quoted context omitted.

Can't have Alzheimer's if you don't have much of a brain left.

Can you explain the joke?

Sounds like this is more "Pouring bleach on germs kills the germs but it also kills everything else"

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#50

Post by Spivak »

lithocarpus wrote: post #43
throwaway27448 wrote: post #36

Earlier quoted context omitted.

Can you explain the joke?

If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/

Synthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle.
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