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Universal vaccine against respiratory infections and allergens

med.stanford.edu

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Re: Universal vaccine against respiratory infections and allergens

#41

Post by rossdavidh »

Animats wrote: post #18
torgoguys wrote: post #3

I don't know much about this, but wouldn't the description of this imply you're stimulating the body to be in an a long-term situation that would be commonly viewed as unpleasant (inflamed, maybe nasal drainage, that type of thing) with the positive tradeoff that you get fewer actual infections?

Right, that's been mentioned elsewhere. A new area of research has opened up. This approach may be more useful for treatment than prevention. It's not really a vaccine; it's more like an induced vaccine response. Keeping the immune system in that state full time might be a problem. But after an infection, that's what's wanted.

I think that "vaccine" is really not the right word to use for this; they sound as different as bandages and blood transfusions. But if it works as advertised, it could be useful if used in the right situation.

I do wonder if the kind of people who got vaccinated 10 times against Covid-19 will end up trying to get a sniff of this every month? Kind of like how we overuse antibiotics in cleaners. It seems like it would be best if saved for an "oh shoot" kind of situation.

Re: Universal vaccine against respiratory infections and allergens

#42

Post by ekianjo »

dionian wrote: post #32
Horatius77 wrote: post #20

Appears that it is trying to stimulate broad immunity .. instead of any one specific virus/disease. Artificial and overstimulation of our immune systems long-term can't be healthy. Definitely a tradeoff here.

you would think so! as a "vaccine skeptic", i think this kind of research is important and patients should be able to decide w/ their doctor which to pursue based on their individual condition. perhaps this tradeoff will be worth it in higher risk individuals.

Until they mandate it...

Re: Universal vaccine against respiratory infections and allergens

#43

Post by gus_massa »

butILoveLife wrote: post #36
Horatius77 wrote: post #20

Appears that it is trying to stimulate broad immunity .. instead of any one specific virus/disease. Artificial and overstimulation of our immune systems long-term can't be healthy. Definitely a tradeoff here.

Cant we say this applies to the flu vaccine? This almost validates why I skip it every year. I get sick after getting the flu vaccine and feel pretty bad for 1-3 days... then I get the flu anyway because they picked the wrong ones.

The normal vaccine is very different. The inmune system learns how to block one virus or bacteria and go to rest until the virus or bacteria appears.

This looks like the inmune system is keep at the emergency level for 3 months.

Re: Universal vaccine against respiratory infections and allergens

#44

Post by adrianN »

gcanyon wrote: post #37
Horatius77 wrote: post #20

Appears that it is trying to stimulate broad immunity .. instead of any one specific virus/disease. Artificial and overstimulation of our immune systems long-term can't be healthy. Definitely a tradeoff here.

> [greater activity within] our immune systems long-term can't be healthy Not trying to be flip, but why? "Natural" isn't always better, and as the obesity epidemic has shown, our evolutionary past hasn't done a perfect job of preparing us for our current environment. You might be right, but I'm skeptical that there is any non-extreme limit to something as simple and mechanical as our innate immune system.

We know that systemic inflammation is associated with all kinds of chronic diseases. I don’t know whether we have figured out which causes which, but I’d be wary of overstimulating the immune system too.

Re: Universal vaccine against respiratory infections and allergens

#46

Post by tshaddox »

ivan_gammel wrote: post #7
torgoguys wrote: post #3

I don't know much about this, but wouldn't the description of this imply you're stimulating the body to be in an a long-term situation that would be commonly viewed as unpleasant (inflamed, maybe nasal drainage, that type of thing) with the positive tradeoff that you get fewer actual infections?

Or worse. If it is so easy to activate, there must be an evolutionary reason why we don’t have it.

There doesn’t need to be an evolutionary reason why we don’t have something. That’s the default!

Re: Universal vaccine against respiratory infections and allergens

#48

Post by Palomides »

gcanyon wrote: post #37
Horatius77 wrote: post #20

Appears that it is trying to stimulate broad immunity .. instead of any one specific virus/disease. Artificial and overstimulation of our immune systems long-term can't be healthy. Definitely a tradeoff here.

> [greater activity within] our immune systems long-term can't be healthy Not trying to be flip, but why? "Natural" isn't always better, and as the obesity epidemic has shown, our evolutionary past hasn't done a perfect job of preparing us for our current environment. You might be right, but I'm skeptical that there is any non-extreme limit to something as simple and mechanical as our innate immune system.

calling the immune system simple and mechanical is completely wild, like half of americans have some kind of medically diagnosable immune dysfunction

Re: Universal vaccine against respiratory infections and allergens

#49

Post by [deleted] »

Palomides wrote: post #48
gcanyon wrote: post #37

Earlier quoted context omitted.

> [greater activity within] our immune systems long-term can't be healthy Not trying to be flip, but why? "Natural" isn't always better, and as the obesity epidemic has shown, our evolutionary past hasn't done a perfect job of preparing us for our current environment. You might be right, but I'm skeptical that there is any non-extreme limit to something as simple and mechanical as our innate immune system.

calling the immune system simple and mechanical is completely wild, like half of americans have some kind of medically diagnosable immune dysfunction

[deleted]

Re: Universal vaccine against respiratory infections and allergens

#50

Post by SecretDreams »

gcanyon wrote: post #37
Horatius77 wrote: post #20

Appears that it is trying to stimulate broad immunity .. instead of any one specific virus/disease. Artificial and overstimulation of our immune systems long-term can't be healthy. Definitely a tradeoff here.

> [greater activity within] our immune systems long-term can't be healthy Not trying to be flip, but why? "Natural" isn't always better, and as the obesity epidemic has shown, our evolutionary past hasn't done a perfect job of preparing us for our current environment. You might be right, but I'm skeptical that there is any non-extreme limit to something as simple and mechanical as our innate immune system.

Normally when your immune system is on high alert for a prolonged period of time, it can lead to more false positives and trigger auto immune issues.
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