41–50 of 95 posts
Wasn't there recently a discussion of a risk of methanol formation from an ethanol producing strain? I sure hope that none of your strains produce ethanol.
Earlier quoted context omitted.
When I asked my doctor about which kinds of probiotics are most effective she specifically mentioned refrigerated vs non-refrigerated is not a way to identify quality or effectiveness unless you know the specific strain(s) needed cannot be made shelf-stable. This lined up with asking my endodontist after they prescribed some antibiotics for a tooth infection. They did warn that the use by dates are a bit bull, not to…
“ and not to try to keep even the shelf-stable ones above room temperature.” - hate to ask, but night brain kicked in - could I trouble you to give me an alternative way of phrasing this? I keep parsing it as “don’t even bother trying to keep probiotics warm”
"even shelf-stable probiotics should not be kept above room temperature".
Earlier quoted context omitted.
When I asked my doctor about which kinds of probiotics are most effective she specifically mentioned refrigerated vs non-refrigerated is not a way to identify quality or effectiveness unless you know the specific strain(s) needed cannot be made shelf-stable. This lined up with asking my endodontist after they prescribed some antibiotics for a tooth infection. They did warn that the use by dates are a bit bull, not to…
Also frankly, doctor =/= expert on probiotics. None of their training really addresses that and while they might be more qualified to read research than random layman I would not in general ascribe authority to what a random practitioner has to say about probiotics. Frankly, the research on probiotics is still very much in its infancy and a LOT remains to be figured out.
Also right to highlight that just because there exist specialist in something does not mean we have the full or correct understanding yet, it's just your best place to find information regarding it unless you want to go join the field.
Great points!
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The Internet almost universally disagrees, based on a quick search: https://seed.com/cultured/probiotics-refrigeration-storage-g...
Lyophilization is a fancy word for freeze-drying. "If a probiotic is refrigerated, it doesn’t mean it’s a better quality" is of course true. But nothing that I said is false. If I am getting probiotics from a quality source, I am going to prefer the refrigerated product over the "shelf-stable" one every time.
On a few occasions when my dog has gotten sick, or needed antibiotics, shelf stabilized probiotics cleaned their digestion right up.
Are strains that only survive when refrigerated probably a higher count? Maybe. Are there stains that are better but can't be freeze dried? Probably. Are there shelf stable probiotics that are worth buying, especially if you don't have access to refrigerated stuff? Absolutely!
Only tangentially relevant, but I’ve dealt with mouth and gut microbiome issues my whole life, the latter exacerbated by a strong antibiotic I had to go on in mid 2017 for a super resistant staph infection. L Reuteri supplementation and “L Reuteri yogurt” was one of those alternative methods I read about (though I’m skeptical that reuteri is the dominant strain in this “yogurt”) Doctors don’t really care to look at t…
I went through a similar post-antibiotics gut nightmare. There are good doctors and there are bad doctors and like everything, there are fewer good ones than bad+average ones.
Seems like you got testing and treatment eventually, I'm sorry it didn't work better; I'm replying less for you and more for anyone who encounters similar. Shop around for your docs!
I got tested very quickly for both H Pylori and SIBO in 2019 on doctor suggestions, I'd never heard of either. Sounds like this was probably around the same time as you went through this based no the antibiotic course that messed up your gut being in 2017).
I went to three doctors in six months, the one that did the testing was the second one. The one who was confident in their knowledge but didn't do anything, including the testing -> immediate no-return-visit from me. The one who said "we don't really know how this works" but also didn't do anything -> no return visit, but appreciate the candor. The one I went back to is the one who said "we don't really know how this works, but let's test for these other things we've learned more about recently, and let's also try some experimental/off-label things." I was actually negative for both of those things, so there was even more random stuff beyond that, but the only one the doctor I liked was really resistant to was a poop transplant, though personally... seems like the only known way to repopulate some of the shit, pun intended.
i remember reading about "lumina probiotic" Has anyone done research on it since, reviewing thier claims ? their claims on their website: replaces S. mutans, alters oral microbiome, reduces acid via ethanol metabolism, produces antibiotic, freshens breath, brightens teeth, lasts decades. etc i am very skeptical of it
I love that this is something that is feasible for someone to just do right now as a hobbyist or blogger. The prices involved here are very reasonable and well within reach of someone wanting to do some project, though not yet at "sequence your microbiome every day" levels. I hope we see a lot more posts like this in the future.
I have just used them to dork around with my home lab to validate cloning results. Now I want to try something like this!
PSA: If a probiotic is on the shelf, not in a cooler, it's probably not worth buying. The best companies certify the count of organisms at time of manufacture , but no counts are guaranteed at the shelf. Probiotics are living organisms and ought to be refrigerated for max lifespan. You can get refrigerated probiotic supps at a place like Whole Foods. Source: I used to work in the industry.
When I asked my doctor about which kinds of probiotics are most effective she specifically mentioned refrigerated vs non-refrigerated is not a way to identify quality or effectiveness unless you know the specific strain(s) needed cannot be made shelf-stable. This lined up with asking my endodontist after they prescribed some antibiotics for a tooth infection. They did warn that the use by dates are a bit bull, not to…
It's not "self-sourced" whatever that means (like that's a bad thing per se?). I saw the sausage being made and I spoke to the sausage makers. The source is the sausage makers, not me. Sorry I don't have a link. These facts may or may not be trade secrets.
Earlier quoted context omitted.
Lyophilization is a fancy word for freeze-drying. "If a probiotic is refrigerated, it doesn’t mean it’s a better quality" is of course true. But nothing that I said is false. If I am getting probiotics from a quality source, I am going to prefer the refrigerated product over the "shelf-stable" one every time.
There's a difference between "choosing one over the other" and the original claim of shelf stabilized probiotics being not worth buying. On a few occasions when my dog has gotten sick, or needed antibiotics, shelf stabilized probiotics cleaned their digestion right up. Are strains that only survive when refrigerated probably a higher count? Maybe. Are there stains that are better but can't be freeze dried? Probably.…
Earlier quoted context omitted.
The Internet almost universally disagrees, based on a quick search: https://seed.com/cultured/probiotics-refrigeration-storage-g...
Why do you think they’re here, sharing the info with you? If you could just Google it up, not nearly as interesting to HN.