Earlier quoted context omitted.
Are you using this?
Yes.
For a brief moment I thought you were Stavros Halkias.
Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
41–50 of 54 posts
Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#42Earlier quoted context omitted.
FWIW, Novo Nordisk also tried to kill their GLP-1 effort several times according to the project lead, Lotte Bjerre Knudsen: https://archive.is/oLnBl In large organizations, I guess a big chunk of success comes from being able to navigate all these political ups and downs.
I wonder how many other great medical innovations have disappeared because of such bureaucracy.
Technically, they disappeared because of limited resources. If every pharmaceutical organization had unlimited funding to run unlimited trials, then they would.
Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#43Nice. This tells me that research on the drug is old and that increases security on its use.
Not necessarily. If it just sits on a shelf, there is no new data on it's use in humans.
Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#44Earlier quoted context omitted.
Do you still take it? I'm looking for some more information on compounded GLP-1 and their safety.
I stopped taking compound Mounjaro a year ago. I started semaglutide in Sept and stopped because it made me sick (throwing up, other non desirable GI effects). My body couldn’t handle semaglutide.
Reportedly retatruide doesn’t cause nausea in as many people, but can still cause diarrhea. May still be worth looking into if you’re interested
Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#45Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#46Earlier quoted context omitted.
Self-injecting feels like a scary, painful, dangerous procedure and becomes completely boring by the third repetition.
The proprietary injector mechanism like for Mounjaro makes it really easy for users. Even compounded versions of it use tiny insulin needles that have near zero pain when injected into the subcutaneous portion of like the stomach while pinched. Source: I took compounded Mounjaro and compounded Ozempic/semaglutide.
Similarly, I grabbed one of the over-the-counter CGM biosensors (Stelo) to gather some data for a couple of weeks and the initial fear of "holy hell, I'm slamming a needle into my arm with something stuck to it" goes away as soon as you slap the injector release.
Just one little clap sound, you feel a little pat on your arm, and the sensor's already made it where it needed to with no pain.
When you remove the sensor it's a little bit of a shock when you see the sensor wire and realize just how small it was and how you never felt it run around inside your arm for a couple weeks.
Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#47> Despite our emerging results, the Pfizer executives in charge of research and external alliances told us the company did not want to develop a new diabetes therapy that required injection, Well, COVID certainly put an end to those fears (by consumers). Coincidentally, obesity was also said to increase COVID risk. Hollywood couldn’t have scripted it - no pun intended - any better.
Wait -your angle is that covid vaccination increased people‘s acceptance of injectable pharmaceutics and covid / its vaccine was made up (or blown out of proportion) so people would get more ozempic?
Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#48Earlier quoted context omitted.
The proprietary injector mechanism like for Mounjaro makes it really easy for users. Even compounded versions of it use tiny insulin needles that have near zero pain when injected into the subcutaneous portion of like the stomach while pinched. Source: I took compounded Mounjaro and compounded Ozempic/semaglutide.
Similarly, I grabbed one of the over-the-counter CGM biosensors (Stelo) to gather some data for a couple of weeks and the initial fear of "holy hell, I'm slamming a needle into my arm with something stuck to it" goes away as soon as you slap the injector release. Just one little clap sound, you feel a little pat on your arm, and the sensor's already made it where it needed to with no pain. When you remove the sensor…
fyi: the impact is an intentional decision. if your nerve endings are signaling something else(hot, cold, movement, etc), a needle prick can get blurred with the rest or ignored altogether. I suspect the bang/clag CGM applicators produce are much the same.
and, for me, its always been the needle moving around thats been mentally disturbing. digging around vecause they missed for the blood draw, trying to hold a large vaccination dose steady as it needs to be injected over 20seconds. So, I suspect the speed itself reduces discomfort.
Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#49Am I the only one that remembers a HUUUGE public media push in the US framing "injecting [any] drug is bad"? with a complete lack of reguard for diabetics, people with fatal allergies, and a host of other people who need to carry, or use needles w/ meds regularly?
Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)
#50> Despite our emerging results, the Pfizer executives in charge of research and external alliances told us the company did not want to develop a new diabetes therapy that required injection, Well, COVID certainly put an end to those fears (by consumers). Coincidentally, obesity was also said to increase COVID risk. Hollywood couldn’t have scripted it - no pun intended - any better.
Wait -your angle is that covid vaccination increased people‘s acceptance of injectable pharmaceutics and covid / its vaccine was made up (or blown out of proportion) so people would get more ozempic?
No. Not my angle. That is exactly what happened.
Injections are no longer a only-if-absolutely-necessary. The stigma is mitigated.