this is such an interesting problem. Imagine expanding the input size to 3.2Gbp, the size of human genome. I wonder if previously unimaginable interactions would occur. Also interesting how everything revolves around U-nets and transformers these days.
> Also interesting how everything revolves around U-nets and transformers these days. To a man with a hammer…
AlphaGenome: AI for better understanding the genome
41–50 of 193 posts
Re: AlphaGenome: AI for better understanding the genome
#42Earlier quoted context omitted.
> Sundar is a really uninspiring leader I understand, but he made google a cash machine. Last quarter BEFORE he was CEO in 2015, google made a quarterly profit of around 3B. Q1 2025 was 35B. a 10x profit growth at this scale well, its unprecedented, the numbers are inspiring themselves, that's his job. He made mistakes sure, but he stuck to google's big gun, ads, and it paid off. The transition to AI started late but…
Their brand is almost cooked though. At least the legacy search part. Maybe they'll morph into AI center of the future, but "Google" has been washed away.
Haven't you been watching the headlines here on HN? The volume of major high-quality Google AI releases has been almost shocking.
And, they've got the best data.
Re: AlphaGenome: AI for better understanding the genome
#43Earlier quoted context omitted.
World is much.. much bigger than HN bubble. Last year, we were all so convinced that Microsoft had it all figured out, and now look at them. Billion is a very, very large number, and sometimes you fail to appreciate how big that is.
Oh I'm conveying opinions other than mines, tech people I work with, that are very very removed from the HN mindset actually, were shitting on google search for a long time this week.
The question will be, when and how will the LLM's be attacked with product placements.
Open marked advertisement in premium models and integrated ads in free tier ones?
I still hope for a mostly adfree world, but in reality google seems in a good position now for the transition towards AI (with ads).
Re: AlphaGenome: AI for better understanding the genome
#44When I went to work at Google in 2008 I immediately advocated for spending significant resources on the biological sciences (this was well before DM started working on biology). I reasoned that Google had the data mangling and ML capabilities required to demonstrate world-leading results (and hopefully guide the way so other biologists could reproduce their techniques). We made some progress- we used exacycle to demo…
> Sundar is a really uninspiring leader I understand, but he made google a cash machine. Last quarter BEFORE he was CEO in 2015, google made a quarterly profit of around 3B. Q1 2025 was 35B. a 10x profit growth at this scale well, its unprecedented, the numbers are inspiring themselves, that's his job. He made mistakes sure, but he stuck to google's big gun, ads, and it paid off. The transition to AI started late but…
If by competitive you mean "We spent $75 Billion dollars and now have a middle of the pack model somewhere between Anthropic and Chinese startup", that's a generous way to put it.
Re: AlphaGenome: AI for better understanding the genome
#45Earlier quoted context omitted.
Could be either. Nevertheless, while tone is tricky in text, the writer is responsible for relieving ambiguity.
eliminating ambiguity is impossible. the reader should work to find the strongest interpretation of the writer's words
Re: AlphaGenome: AI for better understanding the genome
#46Earlier quoted context omitted.
You either attribute both good and bad things to the CEO, or dont. If enshittifying is CEO's fault, then so is Gemini's success.
Why? We've all seen organizations in which some things happen because of the CEO, and others happen in spite of them.
Re: AlphaGenome: AI for better understanding the genome
#47Earlier quoted context omitted.
eliminating ambiguity is impossible. the reader should work to find the strongest interpretation of the writer's words
that’s a lot to expect of readers… good writing needs to give readers every opportunity to find the good in it.
Re: AlphaGenome: AI for better understanding the genome
#48Earlier quoted context omitted.
> Sundar is a really uninspiring leader I understand, but he made google a cash machine. Last quarter BEFORE he was CEO in 2015, google made a quarterly profit of around 3B. Q1 2025 was 35B. a 10x profit growth at this scale well, its unprecedented, the numbers are inspiring themselves, that's his job. He made mistakes sure, but he stuck to google's big gun, ads, and it paid off. The transition to AI started late but…
> The transition to AI started late but gemini is super competitive overall. If by competitive you mean "We spent $75 Billion dollars and now have a middle of the pack model somewhere between Anthropic and Chinese startup", that's a generous way to put it.
Re: AlphaGenome: AI for better understanding the genome
#49Earlier quoted context omitted.
Why? We've all seen organizations in which some things happen because of the CEO, and others happen in spite of them.
But you don’t just get to pick which is which willy nilly just to push your opinions