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Baby is healed with first personalized gene-editing treatment

nytimes.com

41–50 of 570 posts

Re: Baby is healed with first personalized gene-editing treatment

#41

Good thing RFK pushed out the official overseeing this financing and the current administration is actively defunding the organizations that produced this. Better to have more disabled or dead babies instead of science. /s

From a purely utilitarian perspective, funding research like this is not an effective use of dollars at the margin. How many people could we save if an equivalent amount was put into reducing obesity, smoking, and drinking? How many people could we save if we stopped spending money we don't have to do things that the government isn't competent at allocating anyways? That's not to say the research itself is not impres…

I think you may be operating under the assumption that the extremely expensive price tag will need to be repeated for each patient.

In reality, as this process becomes more mature it is going to become inexpensive.

The reduction in cost will almost certainly be similar to reduction in cost needed to sequence an individual's genome, which has fallen from tens of millions to hundreds of dollars.

The only catch is that we have to spend money to get there.

Another catch is that the nations who underwrite this research will turn millions in investments into trillions in dividends and the stingy or poor will be left in the cold.

Seeing that private enterprise is only good at taking publicly-funded work and patenting it, and that in the absence of public funding nothing ever gets invented, we should be all-in on this.

edit: it's apropos that you mentioned obesity because GLP-1 drugs are the direct, irrefutable, product of spending at government labs.

edit2: specifically, a single government scientist playing around with lizard saliva in the 1970s because he thought it was interesting.

Re: Baby is healed with first personalized gene-editing treatment

#42

Earlier quoted context omitted.

From a purely utilitarian perspective, funding research like this is not an effective use of dollars at the margin. How many people could we save if an equivalent amount was put into reducing obesity, smoking, and drinking? How many people could we save if we stopped spending money we don't have to do things that the government isn't competent at allocating anyways? That's not to say the research itself is not impres…

How do you know it's not effective? The cost per life saved is extremely high now , but this stuff gets better over time. How much did penicillin cost to produce originally?

Early penicilin was rare enough that they collected the urine of the first patients and re-extracted penicilin from it for further use.

Re: Baby is healed with first personalized gene-editing treatment

#43
I think it was here a few years ago that I read a comment saying that sick children will be the Trojan horse for normalizing gene editing of humans, because who could say no to sick children, right? Well, guess it's here now, so how long utill the eugenics wars start?

Re: Baby is healed with first personalized gene-editing treatment

#44

Good thing RFK pushed out the official overseeing this financing and the current administration is actively defunding the organizations that produced this. Better to have more disabled or dead babies instead of science. /s

From a purely utilitarian perspective, funding research like this is not an effective use of dollars at the margin. How many people could we save if an equivalent amount was put into reducing obesity, smoking, and drinking? How many people could we save if we stopped spending money we don't have to do things that the government isn't competent at allocating anyways? That's not to say the research itself is not impres…

30 million people in the US are affected by "rare" genetic conditions.

Re: Baby is healed with first personalized gene-editing treatment

#45

Earlier quoted context omitted.

From a purely utilitarian perspective, funding research like this is not an effective use of dollars at the margin. How many people could we save if an equivalent amount was put into reducing obesity, smoking, and drinking? How many people could we save if we stopped spending money we don't have to do things that the government isn't competent at allocating anyways? That's not to say the research itself is not impres…

How do you know it's not effective? The cost per life saved is extremely high now , but this stuff gets better over time. How much did penicillin cost to produce originally?

Isn’t penicillin just bread mold? So probably not a great example.

Re: Baby is healed with first personalized gene-editing treatment

#46

Good thing RFK pushed out the official overseeing this financing and the current administration is actively defunding the organizations that produced this. Better to have more disabled or dead babies instead of science. /s

From a purely utilitarian perspective, funding research like this is not an effective use of dollars at the margin. How many people could we save if an equivalent amount was put into reducing obesity, smoking, and drinking? How many people could we save if we stopped spending money we don't have to do things that the government isn't competent at allocating anyways? That's not to say the research itself is not impres…

Because reducing obesity, smoking and drinking is not a money problem in the slightest.

Re: Baby is healed with first personalized gene-editing treatment

#47
post #27

[flagged]

You complain about oversimplification, then in the same breath complain about "random political stuff" being included. How is that not hypocritical, at best? This medical breakthrough would literally have not been possible without "politics". Get your head out of the sand. No one should be able to escape learning how their politics affects them or the society they are a part of. And if you want to enjoy the benefits…

[deleted]

Re: Baby is healed with first personalized gene-editing treatment

#48

Good thing RFK pushed out the official overseeing this financing and the current administration is actively defunding the organizations that produced this. Better to have more disabled or dead babies instead of science. /s

From a purely utilitarian perspective, funding research like this is not an effective use of dollars at the margin. How many people could we save if an equivalent amount was put into reducing obesity, smoking, and drinking? How many people could we save if we stopped spending money we don't have to do things that the government isn't competent at allocating anyways? That's not to say the research itself is not impres…

I completely disagree, the things you mentioned are all things which a person has a level of control over.

This is something beyond that, and is very valuable as this baby has no actual means of fighting this issue at all.

And who's to say this won't lead to fixing the other things anyway.

Great use of dollars

Re: Baby is healed with first personalized gene-editing treatment

#49
As a father, the idea of being told my 1 week old baby is going to die would be my worst nightmare. The fact these doctors and scientists saved this childs life is a monument to modern medical science. This is absolutely insane. Hopefully the child doesnt need a liver transplant, but this is a great leap forward.

Re: Baby is healed with first personalized gene-editing treatment

#50

Good thing RFK pushed out the official overseeing this financing and the current administration is actively defunding the organizations that produced this. Better to have more disabled or dead babies instead of science. /s

Genuine question: is this research not being pursued in China?

A Chinese scientist claimed that he did CRISPR on twins back in 2018. https://www.science.org/content/article/crispr-bombshell-chi...

He was jailed for illegal medical practices but it seemed like he established a proper lab after serving the sentence and hopefully he is focused on less objectionable practices. https://www.npr.org/2023/06/08/1178695152/china-scientist-he...

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